The Root Growth-Regulating Brevicompanine Natural Products Modulate the Plant Circadian Clock
Plant growth regulating properties of brevicompanines (Brvs), natural products of the fungus Penicillium brevicompactum, have been known for several years, but further investigations into the molecular mechanism of their bioactivity have not been performed. Following chemical synthesis of brevicompanine derivatives, we studied their activity in the model plant Arabidopsis by a combination of plant growth assays, transcriptional profiling, and numerous additional bioassays. These studies demonstrated that brevicompanines cause transcriptional misregulation of core components of the circadian clock, whereas other biological read-outs were not affected. Brevicompanines thus represent promising chemical tools for investigating the regulation of the plant circadian clock. In addition, our study also illustrates the potential of an unbiased -omics-based characterization of bioactive compounds for identifying the often cryptic modes of action of small molecules.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2017 |
|---|---|
| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
|---|---|
| Enthalten in: |
ACS chemical biology - 12(2017), 6 vom: 16. Juni, Seite 1466-1471 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
de Montaigu, Amaury [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Biological Products |
|---|
| Anmerkungen: |
Date Completed 19.09.2017 Date Revised 13.11.2018 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1021/acschembio.6b00978 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM270675655 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM270675655 | ||
| 003 | DE-627 | ||
| 005 | 20231224231054.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231224s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1021/acschembio.6b00978 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0902.xml |
| 035 | |a (DE-627)NLM270675655 | ||
| 035 | |a (NLM)28379676 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a de Montaigu, Amaury |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The Root Growth-Regulating Brevicompanine Natural Products Modulate the Plant Circadian Clock |
| 264 | 1 | |c 2017 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 19.09.2017 | ||
| 500 | |a Date Revised 13.11.2018 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Plant growth regulating properties of brevicompanines (Brvs), natural products of the fungus Penicillium brevicompactum, have been known for several years, but further investigations into the molecular mechanism of their bioactivity have not been performed. Following chemical synthesis of brevicompanine derivatives, we studied their activity in the model plant Arabidopsis by a combination of plant growth assays, transcriptional profiling, and numerous additional bioassays. These studies demonstrated that brevicompanines cause transcriptional misregulation of core components of the circadian clock, whereas other biological read-outs were not affected. Brevicompanines thus represent promising chemical tools for investigating the regulation of the plant circadian clock. In addition, our study also illustrates the potential of an unbiased -omics-based characterization of bioactive compounds for identifying the often cryptic modes of action of small molecules | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Biological Products |2 NLM | |
| 650 | 7 | |a Indoles |2 NLM | |
| 650 | 7 | |a Peptides, Cyclic |2 NLM | |
| 650 | 7 | |a brevicompanine C |2 NLM | |
| 700 | 1 | |a Oeljeklaus, Julian |e verfasserin |4 aut | |
| 700 | 1 | |a Krahn, Jan H |e verfasserin |4 aut | |
| 700 | 1 | |a Suliman, Mohamed N S |e verfasserin |4 aut | |
| 700 | 1 | |a Halder, Vivek |e verfasserin |4 aut | |
| 700 | 1 | |a de Ansorena, Elisa |e verfasserin |4 aut | |
| 700 | 1 | |a Nickel, Sabrina |e verfasserin |4 aut | |
| 700 | 1 | |a Schlicht, Markus |e verfasserin |4 aut | |
| 700 | 1 | |a Plíhal, Ondřej |e verfasserin |4 aut | |
| 700 | 1 | |a Kubiasová, Karolina |e verfasserin |4 aut | |
| 700 | 1 | |a Radová, Lenka |e verfasserin |4 aut | |
| 700 | 1 | |a Kracher, Barbara |e verfasserin |4 aut | |
| 700 | 1 | |a Tóth, Réka |e verfasserin |4 aut | |
| 700 | 1 | |a Kaschani, Farnusch |e verfasserin |4 aut | |
| 700 | 1 | |a Coupland, George |e verfasserin |4 aut | |
| 700 | 1 | |a Kombrink, Erich |e verfasserin |4 aut | |
| 700 | 1 | |a Kaiser, Markus |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t ACS chemical biology |d 2006 |g 12(2017), 6 vom: 16. Juni, Seite 1466-1471 |w (DE-627)NLM167137344 |x 1554-8937 |7 nnns |
| 773 | 1 | 8 | |g volume:12 |g year:2017 |g number:6 |g day:16 |g month:06 |g pages:1466-1471 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1021/acschembio.6b00978 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 12 |j 2017 |e 6 |b 16 |c 06 |h 1466-1471 | ||