Spine Trabecular Bone Score as an Indicator of Bone Microarchitecture at the Peripheral Skeleton in Kidney Transplant Recipients
Copyright © 2017 by the American Society of Nephrology..
BACKGROUND AND OBJECTIVES: Studies using high-resolution peripheral quantitative computed tomography showed progressive abnormalities in cortical and trabecular microarchitecture and biomechanical competence over the first year after kidney transplantation. However, high-resolution peripheral computed tomography is a research tool lacking wide availability. In contrast, the trabecular bone score is a novel and widely available tool that uses gray-scale variograms of the spine image from dual-energy x-ray absorptiometry to assess trabecular quality. There are no studies assessing whether trabecular bone score characterizes bone quality in kidney transplant recipients.
DESIGN, SETTINGS, PARTICIPANTS, & MEASUREMENTS: Between 2009 and 2010, we conducted a study to assess changes in peripheral skeletal microarchitecture, measured by high-resolution peripheral computed tomography, during the first year after transplantation in 47 patients managed with early corticosteroid-withdrawal immunosuppression. All adult first-time transplant candidates were eligible. Patients underwent imaging with high-resolution peripheral computed tomography and dual-energy x-ray absorptiometry pretransplantation and 3, 6, and 12 months post-transplantation. We now test if, during the first year after transplantation, trabecular bone score assesses the evolution of bone microarchitecture and biomechanical competence as determined by high-resolution peripheral computed tomography.
RESULTS: At baseline and follow-up, among the 72% and 78%, respectively, of patients having normal bone mineral density by dual-energy x-ray absorptiometry, 53% and 50%, respectively, were classified by trabecular bone score as having high fracture risk. At baseline, trabecular bone score correlated with spine, hip, and ultradistal radius bone mineral density by dual-energy x-ray absorptiometry and cortical area, density, thickness, and porosity; trabecular density, thickness, separation, and heterogeneity; and stiffness and failure load by high-resolution peripheral computed tomography. Longitudinally, each percentage increase in trabecular bone score was associated with increases in trabecular number (0.35%±1.4%); decreases in trabecular thickness (-0.45%±0.15%), separation (-0.40%±0.15%), and network heterogeneity (-0.48%±0.20%); and increases in failure load (0.22%±0.09%) by high-resolution peripheral computed tomography (all P<0.05).
CONCLUSIONS: Trabecular bone score may be a useful method to assess and monitor bone quality and strength and classify fracture risk in kidney transplant recipients.
| Errataetall: |
CommentIn: Clin J Am Soc Nephrol. 2017 Apr 3;12 (4):562-564. - PMID 28348029 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Clinical journal of the American Society of Nephrology : CJASN - 12(2017), 4 vom: 03. Apr., Seite 644-652 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Luckman, Matthew [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 19.12.2017 Date Revised 13.08.2023 published: Print-Electronic CommentIn: Clin J Am Soc Nephrol. 2017 Apr 3;12 (4):562-564. - PMID 28348029 Citation Status MEDLINE |
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| doi: |
10.2215/CJN.09850916 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM270366849 |
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| 100 | 1 | |a Luckman, Matthew |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Spine Trabecular Bone Score as an Indicator of Bone Microarchitecture at the Peripheral Skeleton in Kidney Transplant Recipients |
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| 500 | |a Date Completed 19.12.2017 | ||
| 500 | |a Date Revised 13.08.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: Clin J Am Soc Nephrol. 2017 Apr 3;12 (4):562-564. - PMID 28348029 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2017 by the American Society of Nephrology. | ||
| 520 | |a BACKGROUND AND OBJECTIVES: Studies using high-resolution peripheral quantitative computed tomography showed progressive abnormalities in cortical and trabecular microarchitecture and biomechanical competence over the first year after kidney transplantation. However, high-resolution peripheral computed tomography is a research tool lacking wide availability. In contrast, the trabecular bone score is a novel and widely available tool that uses gray-scale variograms of the spine image from dual-energy x-ray absorptiometry to assess trabecular quality. There are no studies assessing whether trabecular bone score characterizes bone quality in kidney transplant recipients | ||
| 520 | |a DESIGN, SETTINGS, PARTICIPANTS, & MEASUREMENTS: Between 2009 and 2010, we conducted a study to assess changes in peripheral skeletal microarchitecture, measured by high-resolution peripheral computed tomography, during the first year after transplantation in 47 patients managed with early corticosteroid-withdrawal immunosuppression. All adult first-time transplant candidates were eligible. Patients underwent imaging with high-resolution peripheral computed tomography and dual-energy x-ray absorptiometry pretransplantation and 3, 6, and 12 months post-transplantation. We now test if, during the first year after transplantation, trabecular bone score assesses the evolution of bone microarchitecture and biomechanical competence as determined by high-resolution peripheral computed tomography | ||
| 520 | |a RESULTS: At baseline and follow-up, among the 72% and 78%, respectively, of patients having normal bone mineral density by dual-energy x-ray absorptiometry, 53% and 50%, respectively, were classified by trabecular bone score as having high fracture risk. At baseline, trabecular bone score correlated with spine, hip, and ultradistal radius bone mineral density by dual-energy x-ray absorptiometry and cortical area, density, thickness, and porosity; trabecular density, thickness, separation, and heterogeneity; and stiffness and failure load by high-resolution peripheral computed tomography. Longitudinally, each percentage increase in trabecular bone score was associated with increases in trabecular number (0.35%±1.4%); decreases in trabecular thickness (-0.45%±0.15%), separation (-0.40%±0.15%), and network heterogeneity (-0.48%±0.20%); and increases in failure load (0.22%±0.09%) by high-resolution peripheral computed tomography (all P<0.05) | ||
| 520 | |a CONCLUSIONS: Trabecular bone score may be a useful method to assess and monitor bone quality and strength and classify fracture risk in kidney transplant recipients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Absorptiometry, Photon | |
| 650 | 4 | |a Adrenal Cortex Hormones | |
| 650 | 4 | |a Adult | |
| 650 | 4 | |a Bone Density | |
| 650 | 4 | |a Bone and Bones | |
| 650 | 4 | |a Follow-Up Studies | |
| 650 | 4 | |a Fractures, Bone | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Porosity | |
| 650 | 4 | |a Radius | |
| 650 | 4 | |a Spine | |
| 650 | 4 | |a Tomography | |
| 650 | 4 | |a kidney transplantation | |
| 650 | 4 | |a mineral metabolism | |
| 650 | 4 | |a renal osteodystrophy | |
| 650 | 4 | |a renal transplantation | |
| 700 | 1 | |a Hans, Didier |e verfasserin |4 aut | |
| 700 | 1 | |a Cortez, Natalia |e verfasserin |4 aut | |
| 700 | 1 | |a Nishiyama, Kyle K |e verfasserin |4 aut | |
| 700 | 1 | |a Agarawal, Sanchita |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Chengchen |e verfasserin |4 aut | |
| 700 | 1 | |a Nikkel, Lucas |e verfasserin |4 aut | |
| 700 | 1 | |a Iyer, Sapna |e verfasserin |4 aut | |
| 700 | 1 | |a Fusaro, Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Edward X |e verfasserin |4 aut | |
| 700 | 1 | |a McMahon, Donald J |e verfasserin |4 aut | |
| 700 | 1 | |a Shane, Elizabeth |e verfasserin |4 aut | |
| 700 | 1 | |a Nickolas, Thomas L |e verfasserin |4 aut | |
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