Higher Prevalence of Frailty Among a Sample of HIV-Infected Middle-aged and Older Chinese Adults Is Associated With Neurocognitive Impairment and Depressive Symptoms
© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissionsoup.com..
We investigated the prevalence and correlates of prefrailty/frailty, determined on the basis of the Fried criteria, in Chinese patients with and those without human immunodeficiency virus (HIV) infection. HIV-infected patients were more likely to be frail or prefrail than controls, and this association remained significant after adjustment for potential confounders (odds ratio, 3.79). After additional adjustment for neurocognitive impairment and depressive and insomnia symptoms, this association remained significant but attenuated (odds ratio, 2.16). In the HIV-infected group, these 3 variables were independently associated with prefrailty/frailty. These findings suggest that neurocognitive impairment and depressive and/or insomnia symptoms may account for a higher prevalence of prefrailty/frailty in HIV-infected patients but require further longitudinal investigation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:215 |
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| Enthalten in: |
The Journal of infectious diseases - 215(2017), 5 vom: 01. März, Seite 687-692 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ding, Yingying [VerfasserIn] |
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| Links: |
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| Themen: |
Depressive symptoms |
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| Anmerkungen: |
Date Completed 09.05.2017 Date Revised 07.12.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.1093/infdis/jix032 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissionsoup.com. | ||
| 520 | |a We investigated the prevalence and correlates of prefrailty/frailty, determined on the basis of the Fried criteria, in Chinese patients with and those without human immunodeficiency virus (HIV) infection. HIV-infected patients were more likely to be frail or prefrail than controls, and this association remained significant after adjustment for potential confounders (odds ratio, 3.79). After additional adjustment for neurocognitive impairment and depressive and insomnia symptoms, this association remained significant but attenuated (odds ratio, 2.16). In the HIV-infected group, these 3 variables were independently associated with prefrailty/frailty. These findings suggest that neurocognitive impairment and depressive and/or insomnia symptoms may account for a higher prevalence of prefrailty/frailty in HIV-infected patients but require further longitudinal investigation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a HIV infection | |
| 650 | 4 | |a depressive symptoms | |
| 650 | 4 | |a frailty | |
| 650 | 4 | |a insomnia symptoms. | |
| 650 | 4 | |a neurocognitive impairment | |
| 700 | 1 | |a Lin, Haijiang |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Xing |e verfasserin |4 aut | |
| 700 | 1 | |a Wong, Frank Y |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Yan V |e verfasserin |4 aut | |
| 700 | 1 | |a Marconi, Vincent C |e verfasserin |4 aut | |
| 700 | 1 | |a He, Na |e verfasserin |4 aut | |
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