The concentration of desflurane preventing spectral entropy change during surgical stimulation : A prospective randomized trial
Copyright © 2016 Elsevier Inc. All rights reserved..
STUDY OBJECTIVE: To determine the concentration of desflurane necessary to blunt changes in spectral entropy during surgical incision when two different target-controlled effect-site concentrations of remifentanil (1 and 3ng/ml) were infused.
DESIGN: Prospective, randomized controlled study.
SETTING: Operating room of a university hospital.
INTERVENTIONS: Forty-two patients undergoing general anesthesia for elective surgery were enrolled and randomly allocated to the R1 (1ng/ml of remifentanil, n=21) or R3 (3ng/ml of remifentanil, n=21) group. After at least a 10-min administration of target-controlled remifentanil concentration and predetermined end-tidal desflurane following endotracheal intubation, changes in spectral entropy in response to surgical incision were evaluated.
MEASUREMENTS: Concentration of desflurane necessary to blunt changes in spectral entropy during surgical incision for each group was determined using Dixon's up-and-down method. Hemodynamic variables including mean arterial pressure (MAP) and heart rate (HR) were measured.
MAIN RESULTS: Concentration of desflurane necessary to blunt changes in spectral entropy during surgical incision in 50% of patients (EC50) was 4.1% (95% CI: 3.5-4.7%) for the R1 group and 3.4% (95% CI: 3.0-3.8%) for the R3 group (P=0.033). Additionally, the calculated EC95 values using the logistic regression analysis for the R1 and R3 groups were 5.8% (95% CI: 5.0-10.8%) and 5.1% (95% CI: 4.3-10.6%), respectively. MAPs and HRs were significantly higher in the R1 than in the R3 group after surgical incision.
CONCLUSIONS: Desflurane 4.1% with remifentanil 1ng/ml and desflurane 3.4% with remifentanil 3ng/ml significantly blunt the change in spectral entropy after surgical incision in 50% of patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:37 |
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| Enthalten in: |
Journal of clinical anesthesia - 37(2017) vom: 01. Feb., Seite 86-91 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Han, Sun-Sook [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 14.09.2017 Date Revised 21.03.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jclinane.2016.12.001 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM269275622 |
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| 041 | |a eng | ||
| 100 | 1 | |a Han, Sun-Sook |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The concentration of desflurane preventing spectral entropy change during surgical stimulation |b A prospective randomized trial |
| 264 | 1 | |c 2017 | |
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| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
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| 500 | |a Date Completed 14.09.2017 | ||
| 500 | |a Date Revised 21.03.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2016 Elsevier Inc. All rights reserved. | ||
| 520 | |a STUDY OBJECTIVE: To determine the concentration of desflurane necessary to blunt changes in spectral entropy during surgical incision when two different target-controlled effect-site concentrations of remifentanil (1 and 3ng/ml) were infused | ||
| 520 | |a DESIGN: Prospective, randomized controlled study | ||
| 520 | |a SETTING: Operating room of a university hospital | ||
| 520 | |a INTERVENTIONS: Forty-two patients undergoing general anesthesia for elective surgery were enrolled and randomly allocated to the R1 (1ng/ml of remifentanil, n=21) or R3 (3ng/ml of remifentanil, n=21) group. After at least a 10-min administration of target-controlled remifentanil concentration and predetermined end-tidal desflurane following endotracheal intubation, changes in spectral entropy in response to surgical incision were evaluated | ||
| 520 | |a MEASUREMENTS: Concentration of desflurane necessary to blunt changes in spectral entropy during surgical incision for each group was determined using Dixon's up-and-down method. Hemodynamic variables including mean arterial pressure (MAP) and heart rate (HR) were measured | ||
| 520 | |a MAIN RESULTS: Concentration of desflurane necessary to blunt changes in spectral entropy during surgical incision in 50% of patients (EC50) was 4.1% (95% CI: 3.5-4.7%) for the R1 group and 3.4% (95% CI: 3.0-3.8%) for the R3 group (P=0.033). Additionally, the calculated EC95 values using the logistic regression analysis for the R1 and R3 groups were 5.8% (95% CI: 5.0-10.8%) and 5.1% (95% CI: 4.3-10.6%), respectively. MAPs and HRs were significantly higher in the R1 than in the R3 group after surgical incision | ||
| 520 | |a CONCLUSIONS: Desflurane 4.1% with remifentanil 1ng/ml and desflurane 3.4% with remifentanil 3ng/ml significantly blunt the change in spectral entropy after surgical incision in 50% of patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Randomized Controlled Trial | |
| 650 | 4 | |a Desflurane | |
| 650 | 4 | |a Hemodynamic response | |
| 650 | 4 | |a Remifentanil | |
| 650 | 4 | |a Spectral entropy | |
| 650 | 4 | |a Surgical stimulation | |
| 650 | 7 | |a Anesthetics, Inhalation |2 NLM | |
| 650 | 7 | |a Hypnotics and Sedatives |2 NLM | |
| 650 | 7 | |a Piperidines |2 NLM | |
| 650 | 7 | |a Desflurane |2 NLM | |
| 650 | 7 | |a CRS35BZ94Q |2 NLM | |
| 650 | 7 | |a Isoflurane |2 NLM | |
| 650 | 7 | |a CYS9AKD70P |2 NLM | |
| 650 | 7 | |a Remifentanil |2 NLM | |
| 650 | 7 | |a P10582JYYK |2 NLM | |
| 700 | 1 | |a Han, Sunghee |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Byung-Gook |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Dong-Ho |e verfasserin |4 aut | |
| 700 | 1 | |a Ryu, Jung-Hee |e verfasserin |4 aut | |
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