Management and prognosis of hepatocellular carcinoma in the elderly : Results of an in-field multicenter cohort study
© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd..
AIMS: This multicentre cohort study evaluated the role of ageing on clinical characteristics, treatment allocation and outcome of new hepatocellular carcinomas (HCCs), in clinical practice.
MATERIAL & METHODS: From September 2008, 541 patients >70 years old (elderly group), and 527 ≤70 years old (non-elderly group) with newly diagnosed HCC were consecutively enrolled in 30 Italian centres. Differences in clinical characteristics and treatment allocation between groups were described by a multivariable logistic regression model measuring the inverse probability weight to meet the elderly group. Survival differences were measured by unadjusted and adjusted (by inverse probability weight) survival analysis.
RESULTS: Elderly patients were mainly females, hepatitis C virus infected and with better conserved liver function (P<.001). At presentation, HCC median size was similar in both groups while, in youngers, HCC was more frequently multinodular (P=.001), and associated with neoplastic thrombosis (P=.009). Adjusted survival analysis showed that age did not predict short-mid-term survival (within 24 months), while it was a significant independent predictor of long-term survival. Moreover, age had a significant long-term survival impact mainly on early HCC stages (Barcelona Clinic for Liver Cancer [BCLC] 0-A), its impact on BCLC B stage was lower, while it was negligible for advanced-terminal stages.
CONCLUSIONS: Age per se does not impact on short-mid-term prognosis (≤24 months) of HCC patients, and should not represent a limitation to its management.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:37 |
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| Enthalten in: |
Liver international : official journal of the International Association for the Study of the Liver - 37(2017), 8 vom: 01. Aug., Seite 1184-1192 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Borzio, Mauro [VerfasserIn] |
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| Links: |
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| Themen: |
Cirrhosis |
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| Anmerkungen: |
Date Completed 18.04.2018 Date Revised 11.03.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/liv.13392 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM269089004 |
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| 100 | 1 | |a Borzio, Mauro |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Management and prognosis of hepatocellular carcinoma in the elderly |b Results of an in-field multicenter cohort study |
| 264 | 1 | |c 2017 | |
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| 500 | |a Date Completed 18.04.2018 | ||
| 500 | |a Date Revised 11.03.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. | ||
| 520 | |a AIMS: This multicentre cohort study evaluated the role of ageing on clinical characteristics, treatment allocation and outcome of new hepatocellular carcinomas (HCCs), in clinical practice | ||
| 520 | |a MATERIAL & METHODS: From September 2008, 541 patients >70 years old (elderly group), and 527 ≤70 years old (non-elderly group) with newly diagnosed HCC were consecutively enrolled in 30 Italian centres. Differences in clinical characteristics and treatment allocation between groups were described by a multivariable logistic regression model measuring the inverse probability weight to meet the elderly group. Survival differences were measured by unadjusted and adjusted (by inverse probability weight) survival analysis | ||
| 520 | |a RESULTS: Elderly patients were mainly females, hepatitis C virus infected and with better conserved liver function (P<.001). At presentation, HCC median size was similar in both groups while, in youngers, HCC was more frequently multinodular (P=.001), and associated with neoplastic thrombosis (P=.009). Adjusted survival analysis showed that age did not predict short-mid-term survival (within 24 months), while it was a significant independent predictor of long-term survival. Moreover, age had a significant long-term survival impact mainly on early HCC stages (Barcelona Clinic for Liver Cancer [BCLC] 0-A), its impact on BCLC B stage was lower, while it was negligible for advanced-terminal stages | ||
| 520 | |a CONCLUSIONS: Age per se does not impact on short-mid-term prognosis (≤24 months) of HCC patients, and should not represent a limitation to its management | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a cirrhosis | |
| 650 | 4 | |a elderly | |
| 650 | 4 | |a liver neoplasm | |
| 650 | 4 | |a prognosis | |
| 650 | 4 | |a survival | |
| 700 | 1 | |a Dionigi, Elena |e verfasserin |4 aut | |
| 700 | 1 | |a Vitale, Alessandro |e verfasserin |4 aut | |
| 700 | 1 | |a Rossini, Angelo |e verfasserin |4 aut | |
| 700 | 1 | |a Marignani, Massimo |e verfasserin |4 aut | |
| 700 | 1 | |a Fornari, Fabio |e verfasserin |4 aut | |
| 700 | 1 | |a Vicari, Susanna |e verfasserin |4 aut | |
| 700 | 1 | |a De Sio, Ilario |e verfasserin |4 aut | |
| 700 | 1 | |a Farinati, Fabio |e verfasserin |4 aut | |
| 700 | 1 | |a Bertolini, Emanuela |e verfasserin |4 aut | |
| 700 | 1 | |a Oliveri, Filippo |e verfasserin |4 aut | |
| 700 | 1 | |a Leandro, Gioacchino |e verfasserin |4 aut | |
| 700 | 1 | |a Francica, Giampiero |e verfasserin |4 aut | |
| 700 | 1 | |a Mitra, Mario |e verfasserin |4 aut | |
| 700 | 1 | |a Omazzi, Barbara |e verfasserin |4 aut | |
| 700 | 1 | |a Boccia, Sergio |e verfasserin |4 aut | |
| 700 | 1 | |a Salmi, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Toldi, Anna |e verfasserin |4 aut | |
| 700 | 1 | |a Sacco, Rodolfo |e verfasserin |4 aut | |
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