Fibrin-associated EBV-positive Large B-Cell Lymphoma : An Indolent Neoplasm With Features Distinct From Diffuse Large B-Cell Lymphoma Associated With Chronic Inflammation
Incidental cases of localized fibrin-associated Epstein-Barr virus (EBV)+ large B-cell proliferations have been described at unusual anatomic sites and have been included in the category of diffuse large B-cell lymphoma associated with chronic inflammation (DLBCL-CI) in the WHO Classification. We describe 12 cases and review the literature to define their clinicopathologic spectrum and compare features with typical cases of DLBCL-CI. Median age was 55.5 years with a M:F ratio of 3. In all 12 cases, the lymphoma was an incidental microscopic finding involving atrial myxomas (n=3), thrombi associated with endovascular grafts (n=3), chronic hematomas (n=2), and pseudocysts (n=4). All cases tested were nongerminal center B-cell origin, type III EBV latency, and were negative for MYC rearrangements and alternative lengthening of telomeres by FISH. Most showed high CD30, Ki67, and PD-L1, and low to moderate MYC and p53 expression. Among 11 patients with detailed follow-up, 6 were treated surgically, 3 with cardiac or vascular lesions had persistent/recurrent disease at intravascular sites, and 4 died of causes not directly attributable to lymphoma. Reports of previously published fibrin-associated cases showed similar features, whereas traditional DLBCL-CI cases with a mass lesion had significantly higher lymphoma-associated mortality. Fibrin-associated EBV+ large B-cell lymphoma is clinicopathologically distinct from DLBCL-CI, warranting separate classification. Most cases, particularly those associated with pseudocysts, behave indolently with the potential for cure by surgery alone and may represent a form of EBV+ lymphoproliferative disease rather than lymphoma. However, primary cardiac or vascular disease may have a higher risk of recurrence despite systemic chemotherapy.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2017 |
|---|---|
| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:41 |
|---|---|
| Enthalten in: |
The American journal of surgical pathology - 41(2017), 3 vom: 15. März, Seite 299-312 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Boyer, Daniel F [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Completed 21.07.2017 Date Revised 21.07.2017 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.1097/PAS.0000000000000775 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM268943265 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM268943265 | ||
| 003 | DE-627 | ||
| 005 | 20231224223609.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231224s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1097/PAS.0000000000000775 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0896.xml |
| 035 | |a (DE-627)NLM268943265 | ||
| 035 | |a (NLM)28195879 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Boyer, Daniel F |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Fibrin-associated EBV-positive Large B-Cell Lymphoma |b An Indolent Neoplasm With Features Distinct From Diffuse Large B-Cell Lymphoma Associated With Chronic Inflammation |
| 264 | 1 | |c 2017 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 21.07.2017 | ||
| 500 | |a Date Revised 21.07.2017 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Incidental cases of localized fibrin-associated Epstein-Barr virus (EBV)+ large B-cell proliferations have been described at unusual anatomic sites and have been included in the category of diffuse large B-cell lymphoma associated with chronic inflammation (DLBCL-CI) in the WHO Classification. We describe 12 cases and review the literature to define their clinicopathologic spectrum and compare features with typical cases of DLBCL-CI. Median age was 55.5 years with a M:F ratio of 3. In all 12 cases, the lymphoma was an incidental microscopic finding involving atrial myxomas (n=3), thrombi associated with endovascular grafts (n=3), chronic hematomas (n=2), and pseudocysts (n=4). All cases tested were nongerminal center B-cell origin, type III EBV latency, and were negative for MYC rearrangements and alternative lengthening of telomeres by FISH. Most showed high CD30, Ki67, and PD-L1, and low to moderate MYC and p53 expression. Among 11 patients with detailed follow-up, 6 were treated surgically, 3 with cardiac or vascular lesions had persistent/recurrent disease at intravascular sites, and 4 died of causes not directly attributable to lymphoma. Reports of previously published fibrin-associated cases showed similar features, whereas traditional DLBCL-CI cases with a mass lesion had significantly higher lymphoma-associated mortality. Fibrin-associated EBV+ large B-cell lymphoma is clinicopathologically distinct from DLBCL-CI, warranting separate classification. Most cases, particularly those associated with pseudocysts, behave indolently with the potential for cure by surgery alone and may represent a form of EBV+ lymphoproliferative disease rather than lymphoma. However, primary cardiac or vascular disease may have a higher risk of recurrence despite systemic chemotherapy | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Biomarkers, Tumor |2 NLM | |
| 650 | 7 | |a Fibrin |2 NLM | |
| 650 | 7 | |a 9001-31-4 |2 NLM | |
| 700 | 1 | |a McKelvie, Penelope A |e verfasserin |4 aut | |
| 700 | 1 | |a de Leval, Laurence |e verfasserin |4 aut | |
| 700 | 1 | |a Edlefsen, Kerstin L |e verfasserin |4 aut | |
| 700 | 1 | |a Ko, Young-Hyeh |e verfasserin |4 aut | |
| 700 | 1 | |a Aberman, Zachary A |e verfasserin |4 aut | |
| 700 | 1 | |a Kovach, Alexandra E |e verfasserin |4 aut | |
| 700 | 1 | |a Masih, Aneal |e verfasserin |4 aut | |
| 700 | 1 | |a Nishino, Ha T |e verfasserin |4 aut | |
| 700 | 1 | |a Weiss, Lawrence M |e verfasserin |4 aut | |
| 700 | 1 | |a Meeker, Alan K |e verfasserin |4 aut | |
| 700 | 1 | |a Nardi, Valentina |e verfasserin |4 aut | |
| 700 | 1 | |a Palisoc, Maryknoll |e verfasserin |4 aut | |
| 700 | 1 | |a Shao, Lina |e verfasserin |4 aut | |
| 700 | 1 | |a Pittaluga, Stefania |e verfasserin |4 aut | |
| 700 | 1 | |a Ferry, Judith A |e verfasserin |4 aut | |
| 700 | 1 | |a Harris, Nancy Lee |e verfasserin |4 aut | |
| 700 | 1 | |a Sohani, Aliyah R |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The American journal of surgical pathology |d 1987 |g 41(2017), 3 vom: 15. März, Seite 299-312 |w (DE-627)NLM000259993 |x 1532-0979 |7 nnns |
| 773 | 1 | 8 | |g volume:41 |g year:2017 |g number:3 |g day:15 |g month:03 |g pages:299-312 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1097/PAS.0000000000000775 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 41 |j 2017 |e 3 |b 15 |c 03 |h 299-312 | ||