Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling
Influenza virus infections have a significant impact on global human health. Individuals with suppressed immunity, or suffering from chronic inflammatory conditions such as COPD, are particularly susceptible to influenza. Here we show that suppressor of cytokine signaling (SOCS) five has a pivotal role in restricting influenza A virus in the airway epithelium, through the regulation of epidermal growth factor receptor (EGFR). Socs5-deficient mice exhibit heightened disease severity, with increased viral titres and weight loss. Socs5 levels were differentially regulated in response to distinct influenza viruses (H1N1, H3N2, H5N1 and H11N9) and were reduced in primary epithelial cells from COPD patients, again correlating with increased susceptibility to influenza. Importantly, restoration of SOCS5 levels restricted influenza virus infection, suggesting that manipulating SOCS5 expression and/or SOCS5 targets might be a novel therapeutic approach to influenza.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:6 |
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| Enthalten in: |
eLife - 6(2017) vom: 14. Feb. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kedzierski, Lukasz [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 17.11.2017 Date Revised 02.12.2018 published: Electronic Citation Status MEDLINE |
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| doi: |
10.7554/eLife.20444 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM268939977 |
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| 100 | 1 | |a Kedzierski, Lukasz |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling |
| 264 | 1 | |c 2017 | |
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| 500 | |a Date Completed 17.11.2017 | ||
| 500 | |a Date Revised 02.12.2018 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Influenza virus infections have a significant impact on global human health. Individuals with suppressed immunity, or suffering from chronic inflammatory conditions such as COPD, are particularly susceptible to influenza. Here we show that suppressor of cytokine signaling (SOCS) five has a pivotal role in restricting influenza A virus in the airway epithelium, through the regulation of epidermal growth factor receptor (EGFR). Socs5-deficient mice exhibit heightened disease severity, with increased viral titres and weight loss. Socs5 levels were differentially regulated in response to distinct influenza viruses (H1N1, H3N2, H5N1 and H11N9) and were reduced in primary epithelial cells from COPD patients, again correlating with increased susceptibility to influenza. Importantly, restoration of SOCS5 levels restricted influenza virus infection, suggesting that manipulating SOCS5 expression and/or SOCS5 targets might be a novel therapeutic approach to influenza | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a COPD | |
| 650 | 4 | |a EGFR | |
| 650 | 4 | |a PI3K | |
| 650 | 4 | |a SOCS5 | |
| 650 | 4 | |a cell biology | |
| 650 | 4 | |a human | |
| 650 | 4 | |a infectious disease | |
| 650 | 4 | |a influenza | |
| 650 | 4 | |a innate immunity | |
| 650 | 4 | |a microbiology | |
| 650 | 4 | |a mouse | |
| 650 | 4 | |a virus | |
| 650 | 7 | |a Cytokines |2 NLM | |
| 650 | 7 | |a SOCS5 protein, human |2 NLM | |
| 650 | 7 | |a Socs5 protein, mouse |2 NLM | |
| 650 | 7 | |a Suppressor of Cytokine Signaling Proteins |2 NLM | |
| 650 | 7 | |a EGFR protein, human |2 NLM | |
| 650 | 7 | |a EC 2.7.10.1 |2 NLM | |
| 650 | 7 | |a EGFR protein, mouse |2 NLM | |
| 650 | 7 | |a EC 2.7.10.1 |2 NLM | |
| 650 | 7 | |a ErbB Receptors |2 NLM | |
| 650 | 7 | |a EC 2.7.10.1 |2 NLM | |
| 700 | 1 | |a Tate, Michelle D |e verfasserin |4 aut | |
| 700 | 1 | |a Hsu, Alan C |e verfasserin |4 aut | |
| 700 | 1 | |a Kolesnik, Tatiana B |e verfasserin |4 aut | |
| 700 | 1 | |a Linossi, Edmond M |e verfasserin |4 aut | |
| 700 | 1 | |a Dagley, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Dong, Zhaoguang |e verfasserin |4 aut | |
| 700 | 1 | |a Freeman, Sarah |e verfasserin |4 aut | |
| 700 | 1 | |a Infusini, Giuseppe |e verfasserin |4 aut | |
| 700 | 1 | |a Starkey, Malcolm R |e verfasserin |4 aut | |
| 700 | 1 | |a Bird, Nicola L |e verfasserin |4 aut | |
| 700 | 1 | |a Chatfield, Simon M |e verfasserin |4 aut | |
| 700 | 1 | |a Babon, Jeffrey J |e verfasserin |4 aut | |
| 700 | 1 | |a Huntington, Nicholas |e verfasserin |4 aut | |
| 700 | 1 | |a Belz, Gabrielle |e verfasserin |4 aut | |
| 700 | 1 | |a Webb, Andrew |e verfasserin |4 aut | |
| 700 | 1 | |a Wark, Peter Ab |e verfasserin |4 aut | |
| 700 | 1 | |a Nicola, Nicos A |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Jianqing |e verfasserin |4 aut | |
| 700 | 1 | |a Kedzierska, Katherine |e verfasserin |4 aut | |
| 700 | 1 | |a Hansbro, Philip M |e verfasserin |4 aut | |
| 700 | 1 | |a Nicholson, Sandra E |e verfasserin |4 aut | |
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