Differences in inflammatory marker patterns for adult community-acquired pneumonia patients induced by different pathogens
© 2017 John Wiley & Sons Ltd..
INTRODUCTION: The inflammatory marker patterns of community-acquired Pneumonia (CAP) induced by different microorganisms in adult patients remained unclear.
OBJECTIVES: We aim to explore the inflammatory marker patterns of adult CAP patients induced by different pathogens.
METHODS: Adult CAP patients with definite etiologies were enrolled from September 2010 to June 2012. They were divided into three groups according to the causative pathogens: typical bacteria, Mycoplasma pneumoniae (MP), and viruses. Twenty-seven cytokines and bactericidal/permeability-increasing protein (BPI) levels of serum collected within 7 days onset in these groups were compared.
RESULTS: One hundred twenty-four cases were enrolled for serum detection and analysis, including 10 typical bacterial pneumonia patients, 56 cases with MP pneumonia and 58 with viral pneumonia. Three kinds (PDGF-BB, IP-10, RANTES) of 27 cytokines and BPI levels were significantly elevated in patients with acute pneumonia than healthy controls. Distinct inflammatory marker patterns were released by different pathogens: typical bacterial pneumonia patients had highest levels of BPI, IL-6, IL-8, IL-1rα; while patients caused by MP presented higher levels of PDGF-BB, IL-17A, G-CSF than those caused by viruses. Rhinovirus owned a higher inflammatory response level than the other viruses. The area under the curve (AUC) of PDGF-BB to differentiate MP and virus infection was biggest, which was 0.708.
CONCLUSION: Distinct inflammatory marker patterns were released by different pathogens during acute pneumonia. Significantly increased level of PDGF-BB was observed in acute pneumonia for the first time. It showed a better ability to differentiate MP and virus infection.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
The clinical respiratory journal - 12(2018), 3 vom: 17. März, Seite 974-985 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Liu, Meng [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 27.09.2018 Date Revised 02.12.2018 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/crj.12614 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM268495289 |
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| 245 | 1 | 0 | |a Differences in inflammatory marker patterns for adult community-acquired pneumonia patients induced by different pathogens |
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| 500 | |a Date Revised 02.12.2018 | ||
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2017 John Wiley & Sons Ltd. | ||
| 520 | |a INTRODUCTION: The inflammatory marker patterns of community-acquired Pneumonia (CAP) induced by different microorganisms in adult patients remained unclear | ||
| 520 | |a OBJECTIVES: We aim to explore the inflammatory marker patterns of adult CAP patients induced by different pathogens | ||
| 520 | |a METHODS: Adult CAP patients with definite etiologies were enrolled from September 2010 to June 2012. They were divided into three groups according to the causative pathogens: typical bacteria, Mycoplasma pneumoniae (MP), and viruses. Twenty-seven cytokines and bactericidal/permeability-increasing protein (BPI) levels of serum collected within 7 days onset in these groups were compared | ||
| 520 | |a RESULTS: One hundred twenty-four cases were enrolled for serum detection and analysis, including 10 typical bacterial pneumonia patients, 56 cases with MP pneumonia and 58 with viral pneumonia. Three kinds (PDGF-BB, IP-10, RANTES) of 27 cytokines and BPI levels were significantly elevated in patients with acute pneumonia than healthy controls. Distinct inflammatory marker patterns were released by different pathogens: typical bacterial pneumonia patients had highest levels of BPI, IL-6, IL-8, IL-1rα; while patients caused by MP presented higher levels of PDGF-BB, IL-17A, G-CSF than those caused by viruses. Rhinovirus owned a higher inflammatory response level than the other viruses. The area under the curve (AUC) of PDGF-BB to differentiate MP and virus infection was biggest, which was 0.708 | ||
| 520 | |a CONCLUSION: Distinct inflammatory marker patterns were released by different pathogens during acute pneumonia. Significantly increased level of PDGF-BB was observed in acute pneumonia for the first time. It showed a better ability to differentiate MP and virus infection | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a community-acquired pneumonia | |
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| 700 | 1 | |a Li, Hui |e verfasserin |4 aut | |
| 700 | 1 | |a Xue, Chun Xue |e verfasserin |4 aut | |
| 700 | 1 | |a Gu, Li |e verfasserin |4 aut | |
| 700 | 1 | |a Qu, Jiu Xin |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Xiao Min |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Yi Min |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Ying Mei |e verfasserin |4 aut | |
| 700 | 1 | |a Cao, Bin |e verfasserin |4 aut | |
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