A tale of two glutaminases : homologous enzymes with distinct roles in tumorigenesis
Many cancer cells exhibit an altered metabolic phenotype, in which glutamine consumption is upregulated relative to healthy cells. This metabolic reprogramming often depends upon mitochondrial glutaminase activity, which converts glutamine to glutamate, a key precursor for biosynthetic and bioenergetic processes. Two isozymes of glutaminase exist, a kidney-type (GLS) and a liver-type enzyme (GLS2 or LGA). While a majority of studies have focused on GLS, here we summarize key findings on both glutaminases, describing their structure and function, their roles in cancer and pharmacological approaches to inhibiting their activities.
| Errataetall: |
ErratumIn: Future Med Chem. 2017 Apr;9(5):527. - PMID 28332860 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
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| Enthalten in: |
Future medicinal chemistry - 9(2017), 2 vom: 20. Jan., Seite 223-243 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Katt, William P [VerfasserIn] |
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| Links: |
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| Themen: |
968 |
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| Anmerkungen: |
Date Completed 14.08.2017 Date Revised 26.03.2024 published: Print-Electronic ErratumIn: Future Med Chem. 2017 Apr;9(5):527. - PMID 28332860 Citation Status MEDLINE |
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| doi: |
10.4155/fmc-2016-0190 |
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| PPN (Katalog-ID): |
NLM268236763 |
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| 520 | |a Many cancer cells exhibit an altered metabolic phenotype, in which glutamine consumption is upregulated relative to healthy cells. This metabolic reprogramming often depends upon mitochondrial glutaminase activity, which converts glutamine to glutamate, a key precursor for biosynthetic and bioenergetic processes. Two isozymes of glutaminase exist, a kidney-type (GLS) and a liver-type enzyme (GLS2 or LGA). While a majority of studies have focused on GLS, here we summarize key findings on both glutaminases, describing their structure and function, their roles in cancer and pharmacological approaches to inhibiting their activities | ||
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