Nardonaphthalenones A and B from the roots and rhizomes of Nardostachys chinensis Batal
Copyright © 2017 Elsevier Ltd. All rights reserved..
Nardonaphthalenones A and B (1-2), one new apo-α-carotenone (3) and four new monoterpenoids (4, 8-9 and 11), along with six known compounds (5-7, 10, 12-13) were isolated from the dried roots and rhizomes of Nardostachys chinensis Batal. Their structures were elucidated by analysis of the spectroscopic data including NMR, HRESIMS and circular dichroism data. Furthermore, the serotonin transporter (SERT)-regulating activities of these isolates were evaluated, among them compound 3 showed the strongest enhancement activity while compound 12 showed a moderate inhibition activity on SERT.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:27 |
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| Enthalten in: |
Bioorganic & medicinal chemistry letters - 27(2017), 4 vom: 15. Feb., Seite 875-879 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Deng, Xu [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 04.07.2017 Date Revised 07.02.2018 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.bmcl.2017.01.008 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM268064369 |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2017 Elsevier Ltd. All rights reserved. | ||
| 520 | |a Nardonaphthalenones A and B (1-2), one new apo-α-carotenone (3) and four new monoterpenoids (4, 8-9 and 11), along with six known compounds (5-7, 10, 12-13) were isolated from the dried roots and rhizomes of Nardostachys chinensis Batal. Their structures were elucidated by analysis of the spectroscopic data including NMR, HRESIMS and circular dichroism data. Furthermore, the serotonin transporter (SERT)-regulating activities of these isolates were evaluated, among them compound 3 showed the strongest enhancement activity while compound 12 showed a moderate inhibition activity on SERT | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Iridoid glycoside | |
| 650 | 4 | |a Monoterpenoids | |
| 650 | 4 | |a Nardonaphthalenone | |
| 650 | 4 | |a Nardostachys chinensis Batal. | |
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| 650 | 7 | |a Naphthalenes |2 NLM | |
| 650 | 7 | |a Serotonin Plasma Membrane Transport Proteins |2 NLM | |
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| 700 | 1 | |a Chen, Ying-Peng |e verfasserin |4 aut | |
| 700 | 1 | |a Zheng, Hong-Hong |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Zhong-Ping |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Yan |e verfasserin |4 aut | |
| 700 | 1 | |a Gao, Xiu-Mei |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Yan-Tong |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Hong-Hua |e verfasserin |4 aut | |
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