Potential sponsorship bias in cost-effectiveness analyses of healthcare interventions : A cross-sectional analysis
Copyright © 2016 Elsevier España, S.L.U. All rights reserved..
OBJECTIVE: To examine the relationship between the funding source of cost-effectiveness analyses of healthcare interventions published in Spain and study conclusions.
DESIGN: Descriptive cross-sectional study.
LOCATION: Scientific literature databases (until December 2014).
PARTICIPANTS (ANALYSIS UNITS): Cohort of cost-effectiveness analysis of healthcare interventions published in Spain between 1989-2014 (n=223) presenting quality-adjusted life years (QALYs) as the outcome measure.
MAIN MEASUREMENTS: The relationship between qualitative conclusions of the studies and the type of funding source were established using Fisher's exact test in contingency tables. Distributions of the incremental cost-effectiveness ratios by source of funding in relation to hypothetical willingness to pay thresholds between €30,000-€50,000 per QALY were explored.
RESULTS: A total of 136 (61.0%) studies were funded by industry. The industry-funded studies were less likely to report unfavorable or neutral conclusions than studies non-funded by industry (2.2% vs. 23.0%; P<.0001), largely driven by studies evaluating drugs (0.9% vs. 21.4%; P<.0001). The incremental cost-effectiveness ratios in studies funded by industry were more likely to be below the hypothetical willingness to pay threshold of €30,000 (73.8% vs. 56.3%; P<.0001) and €50,000 (89.4% vs. 68.2%; P<.0001) per QALY.
CONCLUSIONS: This study reveals a potential sponsorship bias in cost-effectiveness analyses of healthcare interventions. Studies funded by industry could be favoring the efficiency profile of their products.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:49 |
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| Enthalten in: |
Atencion primaria - 49(2017), 6 vom: 01. Juni, Seite 335-342 |
| Sprache: |
Spanisch |
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| Weiterer Titel: |
Potencial sesgo de patrocinio en los análisis coste-efectividad de intervenciones sanitarias: un análisis transversal |
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| Beteiligte Personen: |
Catalá-López, Ferrán [VerfasserIn] |
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| Links: |
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| Themen: |
Años de vida ajustados por calidad |
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| Anmerkungen: |
Date Completed 17.05.2018 Date Revised 27.11.2019 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.aprim.2016.08.001 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM26776314X |
|---|
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| 245 | 1 | 0 | |a Potential sponsorship bias in cost-effectiveness analyses of healthcare interventions |b A cross-sectional analysis |
| 246 | 3 | 3 | |a Potencial sesgo de patrocinio en los análisis coste-efectividad de intervenciones sanitarias: un análisis transversal |
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| 500 | |a Date Revised 27.11.2019 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2016 Elsevier España, S.L.U. All rights reserved. | ||
| 520 | |a OBJECTIVE: To examine the relationship between the funding source of cost-effectiveness analyses of healthcare interventions published in Spain and study conclusions | ||
| 520 | |a DESIGN: Descriptive cross-sectional study | ||
| 520 | |a LOCATION: Scientific literature databases (until December 2014) | ||
| 520 | |a PARTICIPANTS (ANALYSIS UNITS): Cohort of cost-effectiveness analysis of healthcare interventions published in Spain between 1989-2014 (n=223) presenting quality-adjusted life years (QALYs) as the outcome measure | ||
| 520 | |a MAIN MEASUREMENTS: The relationship between qualitative conclusions of the studies and the type of funding source were established using Fisher's exact test in contingency tables. Distributions of the incremental cost-effectiveness ratios by source of funding in relation to hypothetical willingness to pay thresholds between €30,000-€50,000 per QALY were explored | ||
| 520 | |a RESULTS: A total of 136 (61.0%) studies were funded by industry. The industry-funded studies were less likely to report unfavorable or neutral conclusions than studies non-funded by industry (2.2% vs. 23.0%; P<.0001), largely driven by studies evaluating drugs (0.9% vs. 21.4%; P<.0001). The incremental cost-effectiveness ratios in studies funded by industry were more likely to be below the hypothetical willingness to pay threshold of €30,000 (73.8% vs. 56.3%; P<.0001) and €50,000 (89.4% vs. 68.2%; P<.0001) per QALY | ||
| 520 | |a CONCLUSIONS: This study reveals a potential sponsorship bias in cost-effectiveness analyses of healthcare interventions. Studies funded by industry could be favoring the efficiency profile of their products | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Años de vida ajustados por calidad | |
| 650 | 4 | |a Bias | |
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| 650 | 4 | |a Quality-adjusted life years | |
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| 650 | 4 | |a Spain | |
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