A meta-analysis of single HCV-untreated arm of studies evaluating outcomes after curative treatments of HCV-related hepatocellular carcinoma
© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd..
BACKGROUND & AIMS: Determining risk for recurrence or survival after curative resection or ablation in patients with hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) is important for stratifying patients according to expected outcomes in future studies of adjuvant therapy in the era of direct-acting antivirals (DAAs). The aims of this meta-analysis were to estimate the recurrence and survival probabilities of HCV-related early HCC following complete response after potentially curative treatment and to identify predictors of recurrence and survival.
METHODS: Studies reporting time-dependent outcomes (HCC recurrence or death) after potentially curative treatment of HCV-related early HCC were identified in MEDLINE through May 2016. Data on patient populations and outcomes were extracted from each study by three independent observers and combined using a distribution-free summary survival curve. Primary outcomes were actuarial probabilities of recurrence and survival.
RESULTS: Eleven studies met the inclusion criteria. Pooled estimates of actuarial recurrence rates were 7.4% at 6 months and 47.0% at 2 years. Pooled estimates of actuarial survival rates were 79.8% at 3 years and 58.6% at 5 years. Heterogeneity among studies was highly significant for all outcomes. By univariate meta-regression analyses, lower serum albumin, randomized controlled trial study design and follow-up were independently associated with higher recurrence risk, whereas tumour size and alpha-foetoprotein levels were associated with higher mortality.
CONCLUSIONS: This meta-analysis showed that recurrence risk and survival are extremely variable in patients with successfully treated HCV-related HCC, providing a useful benchmark for indirect comparisons of the benefits of DAAs and for a correct design of randomized controlled trials in the adjuvant setting.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:37 |
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| Enthalten in: |
Liver international : official journal of the International Association for the Study of the Liver - 37(2017), 8 vom: 01. Aug., Seite 1157-1166 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Cabibbo, Giuseppe [VerfasserIn] |
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| Links: |
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| Themen: |
Hepatocellular carcinoma |
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| Anmerkungen: |
Date Completed 18.04.2018 Date Revised 30.04.2018 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/liv.13357 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM267756895 |
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| 100 | 1 | |a Cabibbo, Giuseppe |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A meta-analysis of single HCV-untreated arm of studies evaluating outcomes after curative treatments of HCV-related hepatocellular carcinoma |
| 264 | 1 | |c 2017 | |
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| 500 | |a Date Revised 30.04.2018 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. | ||
| 520 | |a BACKGROUND & AIMS: Determining risk for recurrence or survival after curative resection or ablation in patients with hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) is important for stratifying patients according to expected outcomes in future studies of adjuvant therapy in the era of direct-acting antivirals (DAAs). The aims of this meta-analysis were to estimate the recurrence and survival probabilities of HCV-related early HCC following complete response after potentially curative treatment and to identify predictors of recurrence and survival | ||
| 520 | |a METHODS: Studies reporting time-dependent outcomes (HCC recurrence or death) after potentially curative treatment of HCV-related early HCC were identified in MEDLINE through May 2016. Data on patient populations and outcomes were extracted from each study by three independent observers and combined using a distribution-free summary survival curve. Primary outcomes were actuarial probabilities of recurrence and survival | ||
| 520 | |a RESULTS: Eleven studies met the inclusion criteria. Pooled estimates of actuarial recurrence rates were 7.4% at 6 months and 47.0% at 2 years. Pooled estimates of actuarial survival rates were 79.8% at 3 years and 58.6% at 5 years. Heterogeneity among studies was highly significant for all outcomes. By univariate meta-regression analyses, lower serum albumin, randomized controlled trial study design and follow-up were independently associated with higher recurrence risk, whereas tumour size and alpha-foetoprotein levels were associated with higher mortality | ||
| 520 | |a CONCLUSIONS: This meta-analysis showed that recurrence risk and survival are extremely variable in patients with successfully treated HCV-related HCC, providing a useful benchmark for indirect comparisons of the benefits of DAAs and for a correct design of randomized controlled trials in the adjuvant setting | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Meta-Analysis | |
| 650 | 4 | |a hepatocellular carcinoma | |
| 650 | 4 | |a prognosis | |
| 650 | 4 | |a recurrences | |
| 650 | 4 | |a survival | |
| 700 | 1 | |a Petta, Salvatore |e verfasserin |4 aut | |
| 700 | 1 | |a Barbàra, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Missale, Gabriele |e verfasserin |4 aut | |
| 700 | 1 | |a Virdone, Roberto |e verfasserin |4 aut | |
| 700 | 1 | |a Caturelli, Eugenio |e verfasserin |4 aut | |
| 700 | 1 | |a Piscaglia, Fabio |e verfasserin |4 aut | |
| 700 | 1 | |a Morisco, Filomena |e verfasserin |4 aut | |
| 700 | 1 | |a Colecchia, Antonio |e verfasserin |4 aut | |
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| 700 | 1 | |a Garuti, Francesca |e investigator |4 oth | |
| 700 | 1 | |a Lenzi, Barbara |e investigator |4 oth | |
| 700 | 1 | |a Biselli, Maurizio |e investigator |4 oth | |
| 700 | 1 | |a Caraceni, Paolo |e investigator |4 oth | |
| 700 | 1 | |a Cucchetti, Alessandro |e investigator |4 oth | |
| 700 | 1 | |a Gramenzi, Annagiulia |e investigator |4 oth | |
| 700 | 1 | |a Granito, Alessandro |e investigator |4 oth | |
| 700 | 1 | |a Magalotti, Donatella |e investigator |4 oth | |
| 700 | 1 | |a Serra, Carla |e investigator |4 oth | |
| 700 | 1 | |a Negrini, Giulia |e investigator |4 oth | |
| 700 | 1 | |a Napoli, Lucia |e investigator |4 oth | |
| 700 | 1 | |a Salvatore, Veronica |e investigator |4 oth | |
| 700 | 1 | |a Benevento, Francesca |e investigator |4 oth | |
| 700 | 1 | |a Benvegnù, Luisa |e investigator |4 oth | |
| 700 | 1 | |a Gazzola, Alessia |e investigator |4 oth | |
| 700 | 1 | |a Murer, Francesca |e investigator |4 oth | |
| 700 | 1 | |a Pozzan, Caterina |e investigator |4 oth | |
| 700 | 1 | |a Vanin, Veronica |e investigator |4 oth | |
| 700 | 1 | |a Moscatelli, Alessandro |e investigator |4 oth | |
| 700 | 1 | |a Pellegatta, Gaia |e investigator |4 oth | |
| 700 | 1 | |a Picciotto, Antonino |e investigator |4 oth | |
| 700 | 1 | |a Savarino, Vincenzo |e investigator |4 oth | |
| 700 | 1 | |a Ciccarese, Francesca |e investigator |4 oth | |
| 700 | 1 | |a Del Poggio, Paolo |e investigator |4 oth | |
| 700 | 1 | |a Olmi, Stefano |e investigator |4 oth | |
| 700 | 1 | |a de Matthaeis, Nicoletta |e investigator |4 oth | |
| 700 | 1 | |a Balsamo, Mariella Di Marco Claudia |e investigator |4 oth | |
| 700 | 1 | |a Vavassori, Elena |e investigator |4 oth | |
| 700 | 1 | |a Roselli, Paola |e investigator |4 oth | |
| 700 | 1 | |a Dell'Isola, Serena |e investigator |4 oth | |
| 700 | 1 | |a Ialungo, Anna Maria |e investigator |4 oth | |
| 700 | 1 | |a Rastrelli, Elena |e investigator |4 oth | |
| 700 | 1 | |a Attardo, Simona |e investigator |4 oth | |
| 700 | 1 | |a Rossi, Margherita |e investigator |4 oth | |
| 700 | 1 | |a Costantino, Andrea |e investigator |4 oth | |
| 700 | 1 | |a Affronti, Andrea |e investigator |4 oth | |
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| 700 | 1 | |a Mascari, Marta |e investigator |4 oth | |
| 700 | 1 | |a Felder, Martina |e investigator |4 oth | |
| 700 | 1 | |a Mega, Andrea |e investigator |4 oth | |
| 700 | 1 | |a Gasbarrini, Antonio |e investigator |4 oth | |
| 700 | 1 | |a Pompili, Maurizio |e investigator |4 oth | |
| 700 | 1 | |a Rinninella, Emanuele |e investigator |4 oth | |
| 700 | 1 | |a Sacco, Rodolfo |e investigator |4 oth | |
| 700 | 1 | |a Mismas, Valeria |e investigator |4 oth | |
| 700 | 1 | |a Foschi, Francesco Giuseppe |e investigator |4 oth | |
| 700 | 1 | |a Dall'Aglio, Anna Chiara |e investigator |4 oth | |
| 700 | 1 | |a Feletti, Valentina |e investigator |4 oth | |
| 700 | 1 | |a Lanzi, Arianna |e investigator |4 oth | |
| 700 | 1 | |a Cappa, Federica Mirici |e investigator |4 oth | |
| 700 | 1 | |a Neri, Elga |e investigator |4 oth | |
| 700 | 1 | |a Stefanini, Giuseppe Francesco |e investigator |4 oth | |
| 700 | 1 | |a Tamberi, Stefano |e investigator |4 oth | |
| 700 | 1 | |a Olivani, Andrea |e investigator |4 oth | |
| 700 | 1 | |a Biasini, Elisabetta |e investigator |4 oth | |
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| 700 | 1 | |a Guarino, Maria |e investigator |4 oth | |
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| 700 | 1 | |a Masotto, Alberto |e investigator |4 oth | |
| 700 | 1 | |a Marchetti, Fabiana |e investigator |4 oth | |
| 700 | 1 | |a Valerio, Matteo |e investigator |4 oth | |
| 700 | 1 | |a Marra, Fabio |e investigator |4 oth | |
| 700 | 1 | |a Aburas, Sami |e investigator |4 oth | |
| 700 | 1 | |a Inghilesi, Andrea L |e investigator |4 oth | |
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| 700 | 1 | |a Zamparelli, Marco Sanduzzi |e investigator |4 oth | |
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