Anterior T-Wave Inversion in Young White Athletes and Nonathletes : Prevalence and Significance
Copyright © 2017 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved..
BACKGROUND: Anterior T-wave inversion (ATWI) on electrocardiography (ECG) in young white adults raises the possibility of cardiomyopathy, specifically arrhythmogenic right ventricular cardiomyopathy (ARVC). Whereas the 2010 European consensus recommendations for ECG interpretation in young athletes state that ATWI beyond lead V1 warrants further investigation, the prevalence and significance of ATWI have never been reported in a large population of asymptomatic whites.
OBJECTIVES: This study investigated the prevalence and significance of ATWI in a large cohort of young, white adults including athletes.
METHODS: Individuals 16 to 35 years of age (n = 14,646), including 4,720 females (32%) and 2,958 athletes (20%), were evaluated by using a health questionnaire, physical examination, and 12-lead ECG. ATWI was defined as T-wave inversion in ≥2 contiguous anterior leads (V1 to V4).
RESULTS: ATWI was detected in 338 individuals (2.3%) and was more common in women than in men (4.3% vs. 1.4%, respectively; p < 0.0001) and more common among athletes than in nonathletes (3.5% vs. 2.0%, respectively; p < 0.0001). T-wave inversion was predominantly confined to leads V1 to V2 (77%). Only 1.2% of women and 0.2% of men exhibited ATWI beyond V2. No one with ATWI fulfilled diagnostic criteria for ARVC after further evaluation. During a mean follow-up of 23.1 ± 12.2 months none of the individuals with ATWI experienced an adverse event.
CONCLUSIONS: ATWI confined to leads V1 to V2 is a normal variant or physiological phenomenon in asymptomatic white individuals without a relevant family history. ATWI beyond V2 is rare, particularly in men, and may warrant investigation.
| Errataetall: |
CommentIn: J Am Coll Cardiol. 2017 Jan 3;69(1):10-12. - PMID 28057232 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:69 |
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| Enthalten in: |
Journal of the American College of Cardiology - 69(2017), 1 vom: 03. Jan., Seite 1-9 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Malhotra, Aneil [VerfasserIn] |
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| Links: |
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| Themen: |
Anterior T-wave inversion |
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| Anmerkungen: |
Date Completed 30.06.2017 Date Revised 21.05.2018 published: Print CommentIn: J Am Coll Cardiol. 2017 Jan 3;69(1):10-12. - PMID 28057232 Citation Status MEDLINE |
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| doi: |
10.1016/j.jacc.2016.10.044 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM267720696 |
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| 500 | |a CommentIn: J Am Coll Cardiol. 2017 Jan 3;69(1):10-12. - PMID 28057232 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2017 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a BACKGROUND: Anterior T-wave inversion (ATWI) on electrocardiography (ECG) in young white adults raises the possibility of cardiomyopathy, specifically arrhythmogenic right ventricular cardiomyopathy (ARVC). Whereas the 2010 European consensus recommendations for ECG interpretation in young athletes state that ATWI beyond lead V1 warrants further investigation, the prevalence and significance of ATWI have never been reported in a large population of asymptomatic whites | ||
| 520 | |a OBJECTIVES: This study investigated the prevalence and significance of ATWI in a large cohort of young, white adults including athletes | ||
| 520 | |a METHODS: Individuals 16 to 35 years of age (n = 14,646), including 4,720 females (32%) and 2,958 athletes (20%), were evaluated by using a health questionnaire, physical examination, and 12-lead ECG. ATWI was defined as T-wave inversion in ≥2 contiguous anterior leads (V1 to V4) | ||
| 520 | |a RESULTS: ATWI was detected in 338 individuals (2.3%) and was more common in women than in men (4.3% vs. 1.4%, respectively; p < 0.0001) and more common among athletes than in nonathletes (3.5% vs. 2.0%, respectively; p < 0.0001). T-wave inversion was predominantly confined to leads V1 to V2 (77%). Only 1.2% of women and 0.2% of men exhibited ATWI beyond V2. No one with ATWI fulfilled diagnostic criteria for ARVC after further evaluation. During a mean follow-up of 23.1 ± 12.2 months none of the individuals with ATWI experienced an adverse event | ||
| 520 | |a CONCLUSIONS: ATWI confined to leads V1 to V2 is a normal variant or physiological phenomenon in asymptomatic white individuals without a relevant family history. ATWI beyond V2 is rare, particularly in men, and may warrant investigation | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a ECG screening | |
| 650 | 4 | |a anterior T-wave inversion | |
| 650 | 4 | |a arrhythmogenic right ventricular cardiomyopathy | |
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