Aminophylline suppresses stress-induced visceral hypersensitivity and defecation in irritable bowel syndrome
Pharmacological therapy for irritable bowel syndrome (IBS) has not been established. In order to find candidate drugs for IBS with diarrhea (IBS-D), we screened a compound library of drugs clinically used for their ability to prevent stress-induced defecation and visceral hypersensitivity in rats. We selected the bronchodilator aminophylline from this library. Using a specific inhibitor for each subtype of adenosine receptors (ARs) and phosphodiesterases (PDEs), we found that both A2BARs and PDE4 are probably mediated the inhibitory effect of aminophylline on wrap restraint stress (WRS)-induced defecation. Aminophylline suppressed maternal separation- and acetic acid administration-induced visceral hypersensitivity to colorectal distension (CRD), which was mediated by both A2AARs and A2BARs. We propose that aminophylline is a candidate drug for IBS-D because of its efficacy in both of stress-induced defecation and visceral hypersensitivity, as we observed here, and because it is clinically safe.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2017 |
|---|---|
| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:7 |
|---|---|
| Enthalten in: |
Scientific reports - 7(2017) vom: 05. Jan., Seite 40214 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Asano, Teita [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
27Y3KJK423 |
|---|
| Anmerkungen: |
Date Completed 15.10.2018 Date Revised 21.03.2022 published: Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1038/srep40214 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM267701292 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM267701292 | ||
| 003 | DE-627 | ||
| 005 | 20231226193506.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231224s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/srep40214 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0892.xml |
| 035 | |a (DE-627)NLM267701292 | ||
| 035 | |a (NLM)28054654 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Asano, Teita |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Aminophylline suppresses stress-induced visceral hypersensitivity and defecation in irritable bowel syndrome |
| 264 | 1 | |c 2017 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 15.10.2018 | ||
| 500 | |a Date Revised 21.03.2022 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Pharmacological therapy for irritable bowel syndrome (IBS) has not been established. In order to find candidate drugs for IBS with diarrhea (IBS-D), we screened a compound library of drugs clinically used for their ability to prevent stress-induced defecation and visceral hypersensitivity in rats. We selected the bronchodilator aminophylline from this library. Using a specific inhibitor for each subtype of adenosine receptors (ARs) and phosphodiesterases (PDEs), we found that both A2BARs and PDE4 are probably mediated the inhibitory effect of aminophylline on wrap restraint stress (WRS)-induced defecation. Aminophylline suppressed maternal separation- and acetic acid administration-induced visceral hypersensitivity to colorectal distension (CRD), which was mediated by both A2AARs and A2BARs. We propose that aminophylline is a candidate drug for IBS-D because of its efficacy in both of stress-induced defecation and visceral hypersensitivity, as we observed here, and because it is clinically safe | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Bronchodilator Agents |2 NLM | |
| 650 | 7 | |a Gastrointestinal Agents |2 NLM | |
| 650 | 7 | |a Aminophylline |2 NLM | |
| 650 | 7 | |a 27Y3KJK423 |2 NLM | |
| 700 | 1 | |a Tanaka, Ken-Ichiro |e verfasserin |4 aut | |
| 700 | 1 | |a Tada, Arisa |e verfasserin |4 aut | |
| 700 | 1 | |a Shimamura, Hikaru |e verfasserin |4 aut | |
| 700 | 1 | |a Tanaka, Rikako |e verfasserin |4 aut | |
| 700 | 1 | |a Maruoka, Hiroki |e verfasserin |4 aut | |
| 700 | 1 | |a Takenaga, Mitsuko |e verfasserin |4 aut | |
| 700 | 1 | |a Mizushima, Tohru |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Scientific reports |d 2011 |g 7(2017) vom: 05. Jan., Seite 40214 |w (DE-627)NLM215703936 |x 2045-2322 |7 nnns |
| 773 | 1 | 8 | |g volume:7 |g year:2017 |g day:05 |g month:01 |g pages:40214 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1038/srep40214 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 7 |j 2017 |b 05 |c 01 |h 40214 | ||