Changing Antimalarial Drug Resistance Patterns Identified by Surveillance at Three Sites in Uganda
© The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissionsoup.com..
We assessed Plasmodium falciparum drug resistance markers in parasites collected in 2012, 2013, and 2015 at 3 sites in Uganda. The prevalence and frequency of parasites with mutations in putative transporters previously associated with resistance to aminoquinolines, but increased sensitivity to lumefantrine (pfcrt 76T; pfmdr1 86Y and 1246Y), decreased markedly at all sites. Antifolate resistance mutations were common, with apparent emergence of mutations (pfdhfr 164L; pfdhps 581G) associated with high-level resistance. K13 mutations linked to artemisinin resistance were uncommon and did not increase over time. Changing malaria treatment practices have been accompanied by profound changes in markers of resistance.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:215 |
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| Enthalten in: |
The Journal of infectious diseases - 215(2017), 4 vom: 15. Feb., Seite 631-635 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tumwebaze, Patrick [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 09.05.2017 Date Revised 01.03.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.1093/infdis/jiw614 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 245 | 1 | 0 | |a Changing Antimalarial Drug Resistance Patterns Identified by Surveillance at Three Sites in Uganda |
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| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissionsoup.com. | ||
| 520 | |a We assessed Plasmodium falciparum drug resistance markers in parasites collected in 2012, 2013, and 2015 at 3 sites in Uganda. The prevalence and frequency of parasites with mutations in putative transporters previously associated with resistance to aminoquinolines, but increased sensitivity to lumefantrine (pfcrt 76T; pfmdr1 86Y and 1246Y), decreased markedly at all sites. Antifolate resistance mutations were common, with apparent emergence of mutations (pfdhfr 164L; pfdhps 581G) associated with high-level resistance. K13 mutations linked to artemisinin resistance were uncommon and did not increase over time. Changing malaria treatment practices have been accompanied by profound changes in markers of resistance | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Malaria | |
| 650 | 4 | |a Plasmodium falciparum | |
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| 650 | 4 | |a artesunate | |
| 650 | 4 | |a chloroquine | |
| 650 | 4 | |a dihydroartemisinin | |
| 650 | 4 | |a drug resistance | |
| 650 | 4 | |a lumefantrine | |
| 650 | 4 | |a pfcrt | |
| 650 | 4 | |a pfmdr1 | |
| 650 | 4 | |a piperaquine | |
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| 650 | 7 | |a Antimalarials |2 NLM | |
| 650 | 7 | |a Artemisinins |2 NLM | |
| 650 | 7 | |a DNA, Protozoan |2 NLM | |
| 650 | 7 | |a Ethanolamines |2 NLM | |
| 650 | 7 | |a Fluorenes |2 NLM | |
| 650 | 7 | |a Folic Acid Antagonists |2 NLM | |
| 650 | 7 | |a Mdr1 protein, Plasmodium falciparum |2 NLM | |
| 650 | 7 | |a Membrane Transport Proteins |2 NLM | |
| 650 | 7 | |a Multidrug Resistance-Associated Proteins |2 NLM | |
| 650 | 7 | |a PfCRT protein, Plasmodium falciparum |2 NLM | |
| 650 | 7 | |a Protozoan Proteins |2 NLM | |
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| 700 | 1 | |a Tukwasibwe, Stephen |e verfasserin |4 aut | |
| 700 | 1 | |a Taylor, Aimee |e verfasserin |4 aut | |
| 700 | 1 | |a Conrad, Melissa |e verfasserin |4 aut | |
| 700 | 1 | |a Ruhamyankaka, Emmanuel |e verfasserin |4 aut | |
| 700 | 1 | |a Asua, Victor |e verfasserin |4 aut | |
| 700 | 1 | |a Walakira, Andrew |e verfasserin |4 aut | |
| 700 | 1 | |a Nankabirwa, Joaniter |e verfasserin |4 aut | |
| 700 | 1 | |a Yeka, Adoke |e verfasserin |4 aut | |
| 700 | 1 | |a Staedke, Sarah G |e verfasserin |4 aut | |
| 700 | 1 | |a Greenhouse, Bryan |e verfasserin |4 aut | |
| 700 | 1 | |a Nsobya, Samuel L |e verfasserin |4 aut | |
| 700 | 1 | |a Kamya, Moses R |e verfasserin |4 aut | |
| 700 | 1 | |a Dorsey, Grant |e verfasserin |4 aut | |
| 700 | 1 | |a Rosenthal, Philip J |e verfasserin |4 aut | |
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