Combined therapy in vulvar lichen sclerosus : does topical tretinoin improve the efficacy of mometasone furoate?
Abstrract Purpose: To assess efficacy and safety profile of combining a potent corticosteroid with a retinoid in the treatment of vulvar lichen sclerosus (VLS).
METHODS: We retrospectively compared 21 VLS patients treated with tretinoin (T) in short-contact therapy and mometasone furoate (MMF) (group A) and 20 treated with cold cream (CC) and MMF (group B) for 5 consecutive days/week for 12 weeks. The efficacy parameters were the response rate, the percentage of patients achieving an improvement from baseline of ≥75% in subjective and objective scores and the mean reduction in subjective and objective scores.
RESULTS: Thirteen patients (75.2%) were considered as responders in group A and 15 (78.9%) in group B; 50% and 61.1% of patients in group A and 100% and 63.1% in group B achieved an improvement of at least 75% in subjective and objective scores, respectively. The scheme combining MMF and CC was better tolerated than the combination of MMF and T.
CONCLUSIONS: The combination with a topical retinoid did not enhance the effectiveness of a potent corticosteroid in the treatment of VLS. Either the scarce efficacy of the short-contact therapy regimen or a less favorable safety profile of such combination may account for these findings.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:28 |
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| Enthalten in: |
The Journal of dermatological treatment - 28(2017), 6 vom: 07. Sept., Seite 559-563 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Borghi, Alessandro [VerfasserIn] |
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| Links: |
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| Themen: |
04201GDN4R |
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| Anmerkungen: |
Date Completed 10.01.2018 Date Revised 02.12.2018 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/09546634.2016.1277178 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM267476477 |
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| 245 | 1 | 0 | |a Combined therapy in vulvar lichen sclerosus |b does topical tretinoin improve the efficacy of mometasone furoate? |
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| 500 | |a Date Completed 10.01.2018 | ||
| 500 | |a Date Revised 02.12.2018 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Abstrract Purpose: To assess efficacy and safety profile of combining a potent corticosteroid with a retinoid in the treatment of vulvar lichen sclerosus (VLS) | ||
| 520 | |a METHODS: We retrospectively compared 21 VLS patients treated with tretinoin (T) in short-contact therapy and mometasone furoate (MMF) (group A) and 20 treated with cold cream (CC) and MMF (group B) for 5 consecutive days/week for 12 weeks. The efficacy parameters were the response rate, the percentage of patients achieving an improvement from baseline of ≥75% in subjective and objective scores and the mean reduction in subjective and objective scores | ||
| 520 | |a RESULTS: Thirteen patients (75.2%) were considered as responders in group A and 15 (78.9%) in group B; 50% and 61.1% of patients in group A and 100% and 63.1% in group B achieved an improvement of at least 75% in subjective and objective scores, respectively. The scheme combining MMF and CC was better tolerated than the combination of MMF and T | ||
| 520 | |a CONCLUSIONS: The combination with a topical retinoid did not enhance the effectiveness of a potent corticosteroid in the treatment of VLS. Either the scarce efficacy of the short-contact therapy regimen or a less favorable safety profile of such combination may account for these findings | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Vulvar lichen sclerosus | |
| 650 | 4 | |a combination regimen | |
| 650 | 4 | |a mometasone furoate | |
| 650 | 4 | |a short-contact therapy | |
| 650 | 4 | |a tretinoin | |
| 650 | 7 | |a Keratolytic Agents |2 NLM | |
| 650 | 7 | |a Mometasone Furoate |2 NLM | |
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| 650 | 7 | |a Tretinoin |2 NLM | |
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| 700 | 1 | |a Toni, Giulia |e verfasserin |4 aut | |
| 700 | 1 | |a Virgili, Annarosa |e verfasserin |4 aut | |
| 700 | 1 | |a Corazza, Monica |e verfasserin |4 aut | |
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