Rhamnolipids form drug-loaded nanoparticles for dermal drug delivery
Copyright © 2016 Elsevier B.V. All rights reserved..
Bacterial biosurfactants are nature's strategy to solubilize and ingest hydrophobic molecules and nutrients using a fully biodegradable transport system. Eight structurally defined rhamnolipids were selected and investigated as potential drug carrier systems. Depending on the molecular structures defining their packing parameters, the rhamnolipids were found to form spherical nanoparticles with precisely defined average sizes between 5 and 100nm, low polydispersity, and stability over a broad concentration range as revealed from dynamic light scattering and electron microscopy. As rhamnolipids were tolerated well by the human skin, rhamnolipid nanoparticles were considered for dermal drug delivery and thus loaded with hydrophobic drug molecules. Using the drug model, Nile red, dexamethasone, and tacrolimus nanoparticles charged with up to 30% drug loading (w/w) were obtained. Nanoparticles loaded with Nile red were investigated for dermal drug delivery in a Franz cell using human skin. Fluoresence microscopy of skin slices indicated the efficient penetration of the model drug into human skin, both into the stratum corneum and although to a lesser extent into the lower epidermis. Rhamnolipid nanocarriers were found to be non-toxic to primary human fibroblasts in a proliferation assay and thus are considered candidates for the dermal delivery of drugs.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:116 |
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| Enthalten in: |
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V - 116(2017) vom: 23. Juli, Seite 31-37 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Müller, Felix [VerfasserIn] |
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| Links: |
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| Themen: |
7S5I7G3JQL |
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| Anmerkungen: |
Date Completed 05.03.2018 Date Revised 05.03.2018 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ejpb.2016.12.013 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM267448929 |
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| 520 | |a Copyright © 2016 Elsevier B.V. All rights reserved. | ||
| 520 | |a Bacterial biosurfactants are nature's strategy to solubilize and ingest hydrophobic molecules and nutrients using a fully biodegradable transport system. Eight structurally defined rhamnolipids were selected and investigated as potential drug carrier systems. Depending on the molecular structures defining their packing parameters, the rhamnolipids were found to form spherical nanoparticles with precisely defined average sizes between 5 and 100nm, low polydispersity, and stability over a broad concentration range as revealed from dynamic light scattering and electron microscopy. As rhamnolipids were tolerated well by the human skin, rhamnolipid nanoparticles were considered for dermal drug delivery and thus loaded with hydrophobic drug molecules. Using the drug model, Nile red, dexamethasone, and tacrolimus nanoparticles charged with up to 30% drug loading (w/w) were obtained. Nanoparticles loaded with Nile red were investigated for dermal drug delivery in a Franz cell using human skin. Fluoresence microscopy of skin slices indicated the efficient penetration of the model drug into human skin, both into the stratum corneum and although to a lesser extent into the lower epidermis. Rhamnolipid nanocarriers were found to be non-toxic to primary human fibroblasts in a proliferation assay and thus are considered candidates for the dermal delivery of drugs | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Dermal drug delivery | |
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| 700 | 1 | |a Hönzke, Stefan |e verfasserin |4 aut | |
| 700 | 1 | |a Luthardt, Wulf-Ole |e verfasserin |4 aut | |
| 700 | 1 | |a Wong, Ee Lin |e verfasserin |4 aut | |
| 700 | 1 | |a Unbehauen, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Bauer, Jörg |e verfasserin |4 aut | |
| 700 | 1 | |a Haag, Rainer |e verfasserin |4 aut | |
| 700 | 1 | |a Hedtrich, Sarah |e verfasserin |4 aut | |
| 700 | 1 | |a Rühl, Eckart |e verfasserin |4 aut | |
| 700 | 1 | |a Rademann, Jörg |e verfasserin |4 aut | |
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