HEV infection in French HIV-infected patients
Copyright © 2016 The British Infection Association. Published by Elsevier Ltd. All rights reserved..
OBJECTIVES: The reported prevalence of anti-hepatitis E virus antibodies in HIV-positive patients from industrialized countries varies greatly. It is also difficult to compare these data with the anti-IgG prevalence in the general population because age and sex are not matched in most studies. Moreover, MSM are at increased risk of viral hepatitis.
METHODS: HEV is endemic in southwestern France. We investigated therefore 300 HIV-infected patients consecutively attending the out-patient clinic of Toulouse University Hospital. Each HIV-infected patient was matched for sex and age with 2 healthy blood donors from the same area. They were tested for anti-HEV IgM and IgG.
RESULTS: Anti-HEV IgG was found in 116 HIV-infected patients (38.7%) and in 284 matched controls (47.3%, p = 0.027). However, anti-HEV IgG concentration tended to be lower in HIV-patients than in controls. Anti-HEV IgM prevalence was similar HIV-infected patients (3.6%) and in matched controls (3.8%, p = 0.85).
CONCLUSION: The prevalence and concentrations of anti-HEV IgG in HIV-infected patients from Southern-France were lower than in controls, suggesting a weaker humoral response. But their prevalences of anti-HEV IgM were similar, indicating a high incidence of HEV infection. These data do not indicate that HEV is transmitted sexually.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2017 |
|---|---|
| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:74 |
|---|---|
| Enthalten in: |
The Journal of infection - 74(2017), 3 vom: 01. März, Seite 310-313 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Abravanel, Florence [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
HEV |
|---|
| Anmerkungen: |
Date Completed 16.10.2017 Date Revised 09.04.2022 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.jinf.2016.12.004 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM26732555X |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM26732555X | ||
| 003 | DE-627 | ||
| 005 | 20231224220435.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231224s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.jinf.2016.12.004 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0891.xml |
| 035 | |a (DE-627)NLM26732555X | ||
| 035 | |a (NLM)27998748 | ||
| 035 | |a (PII)S0163-4453(16)30333-4 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Abravanel, Florence |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a HEV infection in French HIV-infected patients |
| 264 | 1 | |c 2017 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 16.10.2017 | ||
| 500 | |a Date Revised 09.04.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2016 The British Infection Association. Published by Elsevier Ltd. All rights reserved. | ||
| 520 | |a OBJECTIVES: The reported prevalence of anti-hepatitis E virus antibodies in HIV-positive patients from industrialized countries varies greatly. It is also difficult to compare these data with the anti-IgG prevalence in the general population because age and sex are not matched in most studies. Moreover, MSM are at increased risk of viral hepatitis | ||
| 520 | |a METHODS: HEV is endemic in southwestern France. We investigated therefore 300 HIV-infected patients consecutively attending the out-patient clinic of Toulouse University Hospital. Each HIV-infected patient was matched for sex and age with 2 healthy blood donors from the same area. They were tested for anti-HEV IgM and IgG | ||
| 520 | |a RESULTS: Anti-HEV IgG was found in 116 HIV-infected patients (38.7%) and in 284 matched controls (47.3%, p = 0.027). However, anti-HEV IgG concentration tended to be lower in HIV-patients than in controls. Anti-HEV IgM prevalence was similar HIV-infected patients (3.6%) and in matched controls (3.8%, p = 0.85) | ||
| 520 | |a CONCLUSION: The prevalence and concentrations of anti-HEV IgG in HIV-infected patients from Southern-France were lower than in controls, suggesting a weaker humoral response. But their prevalences of anti-HEV IgM were similar, indicating a high incidence of HEV infection. These data do not indicate that HEV is transmitted sexually | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a HEV | |
| 650 | 4 | |a HIV | |
| 650 | 4 | |a Humoral response | |
| 650 | 4 | |a Seroprevalence | |
| 650 | 4 | |a Sexual transmission | |
| 650 | 7 | |a Hepatitis Antibodies |2 NLM | |
| 650 | 7 | |a Immunoglobulin G |2 NLM | |
| 650 | 7 | |a Immunoglobulin M |2 NLM | |
| 650 | 7 | |a RNA, Viral |2 NLM | |
| 700 | 1 | |a Lhomme, Sébastien |e verfasserin |4 aut | |
| 700 | 1 | |a Fougère, Mélanie |e verfasserin |4 aut | |
| 700 | 1 | |a Saune, Karine |e verfasserin |4 aut | |
| 700 | 1 | |a Alvarez, Muriel |e verfasserin |4 aut | |
| 700 | 1 | |a Péron, Jean-Marie |e verfasserin |4 aut | |
| 700 | 1 | |a Delobel, Pierre |e verfasserin |4 aut | |
| 700 | 1 | |a Izopet, Jacques |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The Journal of infection |d 1982 |g 74(2017), 3 vom: 01. März, Seite 310-313 |w (DE-627)NLM012791822 |x 1532-2742 |7 nnns |
| 773 | 1 | 8 | |g volume:74 |g year:2017 |g number:3 |g day:01 |g month:03 |g pages:310-313 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.jinf.2016.12.004 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 74 |j 2017 |e 3 |b 01 |c 03 |h 310-313 | ||