Effects of ZnSO4-induced peripheral anosmia on zebrafish behavior and physiology
Copyright © 2016 Elsevier B.V. All rights reserved..
Olfaction plays a key role in modulating behavioral and physiological responses of various animal species, including fishes. Olfactory deficits can be induced in fish experimentally, and utilized to examine the role of olfaction in their normal and pathological behaviors. Here, we examine whether experimental anosmia, evoked by ZnSO4 in adult zebrafish can be associated with behavioral and/or physiological responses. We show that experimental ZnSO4-induced anosmia caused acute, but not prolonged, anxiogenic-like effects on zebrafish behavior tested in the novel tank test. The procedure also elevated whole-body cortisol levels in zebrafish. Moreover, ZnSO4 treatment, but not sham, produced damage to olfactory epithelium, inducing overt basal cell vacuolization and intercellular edema. The loss of olfaction, assessed by the fish food preference behavior in the aquatic Y-maze, was present 1h, but not 24h, after the treatment. Collectively, this suggests that transient experimental anosmia by ZnSO4 modulates zebrafish behavior and olfaction, which can be used to evoke and assess their stress-related anxiety-like states.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:320 |
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| Enthalten in: |
Behavioural brain research - 320(2017) vom: 01. März, Seite 275-281 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Abreu, Murilo S [VerfasserIn] |
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| Links: |
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| Themen: |
7733-02-0 |
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| Anmerkungen: |
Date Completed 27.12.2017 Date Revised 04.01.2018 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.bbr.2016.12.014 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM267281501 |
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| 500 | |a Date Revised 04.01.2018 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2016 Elsevier B.V. All rights reserved. | ||
| 520 | |a Olfaction plays a key role in modulating behavioral and physiological responses of various animal species, including fishes. Olfactory deficits can be induced in fish experimentally, and utilized to examine the role of olfaction in their normal and pathological behaviors. Here, we examine whether experimental anosmia, evoked by ZnSO4 in adult zebrafish can be associated with behavioral and/or physiological responses. We show that experimental ZnSO4-induced anosmia caused acute, but not prolonged, anxiogenic-like effects on zebrafish behavior tested in the novel tank test. The procedure also elevated whole-body cortisol levels in zebrafish. Moreover, ZnSO4 treatment, but not sham, produced damage to olfactory epithelium, inducing overt basal cell vacuolization and intercellular edema. The loss of olfaction, assessed by the fish food preference behavior in the aquatic Y-maze, was present 1h, but not 24h, after the treatment. Collectively, this suggests that transient experimental anosmia by ZnSO4 modulates zebrafish behavior and olfaction, which can be used to evoke and assess their stress-related anxiety-like states | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Anxiety | |
| 650 | 4 | |a Emotional behavior | |
| 650 | 4 | |a Experimental anosmia protocol | |
| 650 | 4 | |a Olfactory deprivation | |
| 650 | 4 | |a Zebrafish | |
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| 700 | 1 | |a Rodriguez, Rubens |e verfasserin |4 aut | |
| 700 | 1 | |a Kalueff, Allan V |e verfasserin |4 aut | |
| 700 | 1 | |a Barcellos, Leonardo J G |e verfasserin |4 aut | |
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