Increased serum levels of macrophage activation marker sCD163 in Dengue patients
Copyright © 2016 Elsevier B.V. All rights reserved..
BACKGROUND: Dengue viruses are known to infect and replicate in macrophages. Thus studying the host responsive molecules that are specifically released by macrophages during the course of dengue infection may provide better understanding on dengue immunopathogenesis. Soluble CD163 (sCD163) is a scavenger receptor, highly expressed on macrophages reported to be involved in some viral disease. The participation of sCD163 in dengue is not known.
OBJECTIVE: The present study aimed to explore the role of sCD163 as a potential biomarker for predicting dengue disease.
STUDY DESIGN: Using a case-control design, 82 dengue subjects consisting of 69 non-severe dengue (NSD) and 13 severe dengue (SD) along with 32 non-dengue other febrile illness (OFI) subjects and 30 healthy subjects were involved in the study. The serum concentration of sCD163 was determined in the study subjects at admission and around defervescence using ELISA. Statistical analysis was done using Mann-Whitney U test andWilcoxon signed rank test.
RESULTS: The study recorded a significant increase in the sCD163 serum level at defervescence phase specifically among dengue group compared to OFI. sCD163 was also found to be significantly higher in secondary cases compared to primary at both admission and defervescence. Furthermore,a higher level of sCD163 was also observed in SD compared to NSD cases, although no statistical significance was observed CONCLUSION: The study substantiates the role of macrophage activation in dengue pathogenesis and further study is needed to decipher the exact role of sCD163 in the disease pathogenesis and to explore its potential as a marker for the early prediction of dengue severity.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:86 |
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| Enthalten in: |
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 86(2017) vom: 15. Jan., Seite 62-67 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
S S, Sarayu Gopal [VerfasserIn] |
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| Links: |
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| Themen: |
Antigens, CD |
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| Anmerkungen: |
Date Completed 03.01.2018 Date Revised 09.03.2018 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jcv.2016.10.009 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM267085915 |
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| 245 | 1 | 0 | |a Increased serum levels of macrophage activation marker sCD163 in Dengue patients |
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| 500 | |a Date Revised 09.03.2018 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2016 Elsevier B.V. All rights reserved. | ||
| 520 | |a BACKGROUND: Dengue viruses are known to infect and replicate in macrophages. Thus studying the host responsive molecules that are specifically released by macrophages during the course of dengue infection may provide better understanding on dengue immunopathogenesis. Soluble CD163 (sCD163) is a scavenger receptor, highly expressed on macrophages reported to be involved in some viral disease. The participation of sCD163 in dengue is not known | ||
| 520 | |a OBJECTIVE: The present study aimed to explore the role of sCD163 as a potential biomarker for predicting dengue disease | ||
| 520 | |a STUDY DESIGN: Using a case-control design, 82 dengue subjects consisting of 69 non-severe dengue (NSD) and 13 severe dengue (SD) along with 32 non-dengue other febrile illness (OFI) subjects and 30 healthy subjects were involved in the study. The serum concentration of sCD163 was determined in the study subjects at admission and around defervescence using ELISA. Statistical analysis was done using Mann-Whitney U test andWilcoxon signed rank test | ||
| 520 | |a RESULTS: The study recorded a significant increase in the sCD163 serum level at defervescence phase specifically among dengue group compared to OFI. sCD163 was also found to be significantly higher in secondary cases compared to primary at both admission and defervescence. Furthermore,a higher level of sCD163 was also observed in SD compared to NSD cases, although no statistical significance was observed CONCLUSION: The study substantiates the role of macrophage activation in dengue pathogenesis and further study is needed to decipher the exact role of sCD163 in the disease pathogenesis and to explore its potential as a marker for the early prediction of dengue severity | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Macrophage activation | |
| 650 | 4 | |a sCD163 | |
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| 650 | 7 | |a Antigens, Differentiation, Myelomonocytic |2 NLM | |
| 650 | 7 | |a Biomarkers |2 NLM | |
| 650 | 7 | |a CD163 antigen |2 NLM | |
| 650 | 7 | |a Receptors, Cell Surface |2 NLM | |
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| 700 | 1 | |a T, Kadhiravan |e verfasserin |4 aut | |
| 700 | 1 | |a Dhodapkar, Rahul |e verfasserin |4 aut | |
| 700 | 1 | |a Kah, James |e verfasserin |4 aut | |
| 700 | 1 | |a Rajendiran, Soundravally |e verfasserin |4 aut | |
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