The C-reactive protein/albumin ratio predicts long-term outcomes of patients with operable non-small cell lung cancer
PURPOSE: To investigate the association between C-reactive protein/albumin ratio (CAR), an inflammation-based prognostic score, and clinicopathological factors, as well as its association with long-term outcomes in patients with operable non-small cell lung cancer (NSCLC).
METHODS: A total of 617 operable NSCLC patients were retrospectively evaluated and the data of preoperative serum CRP and serum albumin was collected. The correlation between the CAR and clinicopathological factors was analyzed using the chi-square test. A Cox proportional hazards regression model was performed to evaluate the association between the CAR and outcome.
RESULTS: The CAR was significantly related to sex, smoking status, BMI, histology type and clinical stage (p ≤ 0.05). The patients with characteristic of male, smoker, BMI under 18.5, squamous cell carcinoma or clinical stage III had a high level of CAR. Additionally, elevated CAR indicated a worse outcome, and the patients with higher CAR had 2.02-fold risk for disease progression (95% CI 1.48-2.74, p < 0.001) and 2.61-fold risk for death (95 % CI 2.02-3.37, p < 0.001). Multivariate analyses showed the similar results after adjusted by clinicopathological factors and another four inflammation-based prognostic scores.
CONCLUSIONS: The CAR is a potential independent predictor for disease progression and death in patients with operable NSCLC.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:8 |
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| Enthalten in: |
Oncotarget - 8(2017), 5 vom: 31. Jan., Seite 8835-8842 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhang, Fanrong [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 20.02.2018 Date Revised 12.11.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.18632/oncotarget.13053 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM266015727 |
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| 100 | 1 | |a Zhang, Fanrong |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The C-reactive protein/albumin ratio predicts long-term outcomes of patients with operable non-small cell lung cancer |
| 264 | 1 | |c 2017 | |
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| 500 | |a Date Revised 12.11.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a PURPOSE: To investigate the association between C-reactive protein/albumin ratio (CAR), an inflammation-based prognostic score, and clinicopathological factors, as well as its association with long-term outcomes in patients with operable non-small cell lung cancer (NSCLC) | ||
| 520 | |a METHODS: A total of 617 operable NSCLC patients were retrospectively evaluated and the data of preoperative serum CRP and serum albumin was collected. The correlation between the CAR and clinicopathological factors was analyzed using the chi-square test. A Cox proportional hazards regression model was performed to evaluate the association between the CAR and outcome | ||
| 520 | |a RESULTS: The CAR was significantly related to sex, smoking status, BMI, histology type and clinical stage (p ≤ 0.05). The patients with characteristic of male, smoker, BMI under 18.5, squamous cell carcinoma or clinical stage III had a high level of CAR. Additionally, elevated CAR indicated a worse outcome, and the patients with higher CAR had 2.02-fold risk for disease progression (95% CI 1.48-2.74, p < 0.001) and 2.61-fold risk for death (95 % CI 2.02-3.37, p < 0.001). Multivariate analyses showed the similar results after adjusted by clinicopathological factors and another four inflammation-based prognostic scores | ||
| 520 | |a CONCLUSIONS: The CAR is a potential independent predictor for disease progression and death in patients with operable NSCLC | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Zhang, Nan |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Junzhou |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Yimin |e verfasserin |4 aut | |
| 700 | 1 | |a Su, Dan |e verfasserin |4 aut | |
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