Evaluation of long-term safety and efficacy of omalizumab in elderly patients with uncontrolled allergic asthma
Copyright © 2016 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved..
BACKGROUND: Severe asthma management in elderly patients may be difficult because of increased comorbid conditions, polypharmacy, physiologic changes that occur with aging, incorrect use of inhaler devices, and poor adherence.
OBJECTIVE: To evaluate the long-term safety and efficacy of the anti-IgE antibody omalizumab in elderly (aged ≥65 years) patients with uncontrolled allergic asthma.
METHODS: The efficiency and adverse effects of omalizumab treatment were evaluated based on data extracted from medical records. Patients were evaluated monthly for efficacy and adverse reactions. Treatment efficacy was evaluated by level of asthma symptom control, using the Global Initiative for Asthma guideline.
RESULTS: Nineteen consecutive elderly patients with asthma (female to male ratio, 14:5) formed our cohort. The mean (SD) age, disease duration, and total IgE level were 69.3 (5.8) years, 19.4 (8.6) years, and 299.1 (197.2) IU/mL, respectively. The mean (SD) duration of omalizumab treatment was 35.6 (17.8) months (range, 9-66 months). All the patients had at least 1 perennial inhalant allergen sensitivity and had uncontrolled allergic asthma. Elderly patients experienced no significantly important adverse reaction considered to be related to omalizumab treatment. Only 1 patient had a local adverse reaction and 1 had myalgia that was considered to be drug related. After omalizumab treatment, asthma symptoms were well controlled in 9 patients (47.4%) and partly controlled in 8 patients (42.1%). Two of the patients (10.5%) still had uncontrolled asthma.
CONCLUSION: Our study found that omalizumab is a well-tolerated and effective therapy for elderly patients with uncontrolled asthma.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2016 |
---|---|
Erschienen: |
2016 |
Enthalten in: |
Zur Gesamtaufnahme - volume:117 |
---|---|
Enthalten in: |
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology - 117(2016), 5 vom: 01. Nov., Seite 546-549 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Tat, Tugba Songul [VerfasserIn] |
---|
Links: |
---|
Themen: |
2P471X1Z11 |
---|
Anmerkungen: |
Date Completed 02.08.2017 Date Revised 04.12.2017 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1016/j.anai.2016.09.006 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM265715792 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM265715792 | ||
003 | DE-627 | ||
005 | 20231224212908.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231224s2016 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1016/j.anai.2016.09.006 |2 doi | |
028 | 5 | 2 | |a pubmed24n0885.xml |
035 | |a (DE-627)NLM265715792 | ||
035 | |a (NLM)27788886 | ||
035 | |a (PII)S1081-1206(16)30633-0 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Tat, Tugba Songul |e verfasserin |4 aut | |
245 | 1 | 0 | |a Evaluation of long-term safety and efficacy of omalizumab in elderly patients with uncontrolled allergic asthma |
264 | 1 | |c 2016 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 02.08.2017 | ||
500 | |a Date Revised 04.12.2017 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2016 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved. | ||
520 | |a BACKGROUND: Severe asthma management in elderly patients may be difficult because of increased comorbid conditions, polypharmacy, physiologic changes that occur with aging, incorrect use of inhaler devices, and poor adherence | ||
520 | |a OBJECTIVE: To evaluate the long-term safety and efficacy of the anti-IgE antibody omalizumab in elderly (aged ≥65 years) patients with uncontrolled allergic asthma | ||
520 | |a METHODS: The efficiency and adverse effects of omalizumab treatment were evaluated based on data extracted from medical records. Patients were evaluated monthly for efficacy and adverse reactions. Treatment efficacy was evaluated by level of asthma symptom control, using the Global Initiative for Asthma guideline | ||
520 | |a RESULTS: Nineteen consecutive elderly patients with asthma (female to male ratio, 14:5) formed our cohort. The mean (SD) age, disease duration, and total IgE level were 69.3 (5.8) years, 19.4 (8.6) years, and 299.1 (197.2) IU/mL, respectively. The mean (SD) duration of omalizumab treatment was 35.6 (17.8) months (range, 9-66 months). All the patients had at least 1 perennial inhalant allergen sensitivity and had uncontrolled allergic asthma. Elderly patients experienced no significantly important adverse reaction considered to be related to omalizumab treatment. Only 1 patient had a local adverse reaction and 1 had myalgia that was considered to be drug related. After omalizumab treatment, asthma symptoms were well controlled in 9 patients (47.4%) and partly controlled in 8 patients (42.1%). Two of the patients (10.5%) still had uncontrolled asthma | ||
520 | |a CONCLUSION: Our study found that omalizumab is a well-tolerated and effective therapy for elderly patients with uncontrolled asthma | ||
650 | 4 | |a Journal Article | |
650 | 7 | |a Allergens |2 NLM | |
650 | 7 | |a Anti-Asthmatic Agents |2 NLM | |
650 | 7 | |a Omalizumab |2 NLM | |
650 | 7 | |a 2P471X1Z11 |2 NLM | |
650 | 7 | |a Immunoglobulin E |2 NLM | |
650 | 7 | |a 37341-29-0 |2 NLM | |
700 | 1 | |a Cilli, Aykut |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology |d 1995 |g 117(2016), 5 vom: 01. Nov., Seite 546-549 |w (DE-627)NLM075127695 |x 1534-4436 |7 nnns |
773 | 1 | 8 | |g volume:117 |g year:2016 |g number:5 |g day:01 |g month:11 |g pages:546-549 |
856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.anai.2016.09.006 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 117 |j 2016 |e 5 |b 01 |c 11 |h 546-549 |