The microRNA miR-33a suppresses IL-6-induced tumor progression by binding Twist in gallbladder cancer
Cytokine is a key molecular link between chronic inflammation and gallbladder cancer (GBC) progression. The potential mechanism of cytokine-associated modulation of microRNAs (miRNAs) expression in GBC progression is not fully understood. In this study, we investigated the biological effects and prognostic significance of interleukin-6 (IL-6) -induced miRNAs in the development of GBC. We identify that inflammatory cytokine, IL-6 promotes proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) of GBC both in vitro and in vivo. Among all the changed miRNAs in miRNA profiling, miR-33a expression was significantly decreased in IL-6 treated GBC cell lines, as well as in GBC tissues compared with case-matched normal tissues and cholecystitis tissues. In turn, miR-33a suppresses IL-6-induced tumor metastasis by directly binding Twist which was identified as an EMT marker. High expression of miR-33a suppressed xenograft tumor growth and dissemination in nude mice. The downregulation of miR-33a was closely associated with advanced clinical stage, lymph node metastasis, and poor clinical outcomes in patients with GBC. miR-33a acts as a tumor suppressor miRNA in GBC progression and may be considered for the development of potential therapeutics against GBC.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:7 |
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| Enthalten in: |
Oncotarget - 7(2016), 48 vom: 29. Nov., Seite 78640-78652 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhang, Mingdi [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 20.02.2018 Date Revised 05.02.2020 published: Print Citation Status MEDLINE |
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| doi: |
10.18632/oncotarget.12693 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM265547261 |
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| 100 | 1 | |a Zhang, Mingdi |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The microRNA miR-33a suppresses IL-6-induced tumor progression by binding Twist in gallbladder cancer |
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| 520 | |a Cytokine is a key molecular link between chronic inflammation and gallbladder cancer (GBC) progression. The potential mechanism of cytokine-associated modulation of microRNAs (miRNAs) expression in GBC progression is not fully understood. In this study, we investigated the biological effects and prognostic significance of interleukin-6 (IL-6) -induced miRNAs in the development of GBC. We identify that inflammatory cytokine, IL-6 promotes proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) of GBC both in vitro and in vivo. Among all the changed miRNAs in miRNA profiling, miR-33a expression was significantly decreased in IL-6 treated GBC cell lines, as well as in GBC tissues compared with case-matched normal tissues and cholecystitis tissues. In turn, miR-33a suppresses IL-6-induced tumor metastasis by directly binding Twist which was identified as an EMT marker. High expression of miR-33a suppressed xenograft tumor growth and dissemination in nude mice. The downregulation of miR-33a was closely associated with advanced clinical stage, lymph node metastasis, and poor clinical outcomes in patients with GBC. miR-33a acts as a tumor suppressor miRNA in GBC progression and may be considered for the development of potential therapeutics against GBC | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Chu, Bingfeng |e verfasserin |4 aut | |
| 700 | 1 | |a Tang, Zhaohui |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Yong |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Yong |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Di |e verfasserin |4 aut | |
| 700 | 1 | |a Weng, Mingzhe |e verfasserin |4 aut | |
| 700 | 1 | |a Qin, Yiyu |e verfasserin |4 aut | |
| 700 | 1 | |a Ma, Mingzhe |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Alex |e verfasserin |4 aut | |
| 700 | 1 | |a Ma, Fei |e verfasserin |4 aut | |
| 700 | 1 | |a Quan, Zhiwei |e verfasserin |4 aut | |
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