Reassortant Eurasian Avian-Like Influenza A(H1N1) Virus from a Severely Ill Child, Hunan Province, China, 2015
In 2015, a novel influenza A(H1N1) virus was isolated from a boy in China who had severe pneumonia. The virus was a genetic reassortant of Eurasian avian-like influenza A(H1N1) (EA-H1N1) virus. The hemagglutinin, neuraminidase, and matrix genes of the reassortant virus were highly similar to genes in EA-H1N1 swine influenza viruses, the polybasic 1 and 2, polymerase acidic, and nucleoprotein genes originated from influenza A(H1N1)pdm09 virus, and the nonstructural protein gene derived from classical swine influenza A(H1N1) (CS H1N1) virus. In a mouse model, the reassortant virus, termed influenza A/Hunan/42443/2015(H1N1) virus, showed higher infectivity and virulence than another human EA-H1N1 isolate, influenza A/Jiangsu/1/2011(H1N1) virus. In the respiratory tract of mice, virus replication by influenza A/Hunan/42443/2015(H1N1) virus was substantially higher than that by influenza A/Jiangsu/1/2011(H1N1) virus. Human-to-human transmission of influenza A/Hunan/42443/2015(H1N1) virus has not been detected; however, given the circulation of novel EA-H1N1 viruses in pigs, enhanced surveillance should be instituted among swine and humans.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
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| Enthalten in: |
Emerging infectious diseases - 22(2016), 11 vom: 20. Nov., Seite 1930-1936 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhu, Wenfei [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 12.01.2018 Date Revised 13.11.2018 published: Print Citation Status MEDLINE |
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| doi: |
10.3201/eid2211.160181 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
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| 100 | 1 | |a Zhu, Wenfei |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Reassortant Eurasian Avian-Like Influenza A(H1N1) Virus from a Severely Ill Child, Hunan Province, China, 2015 |
| 264 | 1 | |c 2016 | |
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| 500 | |a Date Completed 12.01.2018 | ||
| 500 | |a Date Revised 13.11.2018 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a In 2015, a novel influenza A(H1N1) virus was isolated from a boy in China who had severe pneumonia. The virus was a genetic reassortant of Eurasian avian-like influenza A(H1N1) (EA-H1N1) virus. The hemagglutinin, neuraminidase, and matrix genes of the reassortant virus were highly similar to genes in EA-H1N1 swine influenza viruses, the polybasic 1 and 2, polymerase acidic, and nucleoprotein genes originated from influenza A(H1N1)pdm09 virus, and the nonstructural protein gene derived from classical swine influenza A(H1N1) (CS H1N1) virus. In a mouse model, the reassortant virus, termed influenza A/Hunan/42443/2015(H1N1) virus, showed higher infectivity and virulence than another human EA-H1N1 isolate, influenza A/Jiangsu/1/2011(H1N1) virus. In the respiratory tract of mice, virus replication by influenza A/Hunan/42443/2015(H1N1) virus was substantially higher than that by influenza A/Jiangsu/1/2011(H1N1) virus. Human-to-human transmission of influenza A/Hunan/42443/2015(H1N1) virus has not been detected; however, given the circulation of novel EA-H1N1 viruses in pigs, enhanced surveillance should be instituted among swine and humans | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a Historical Article | |
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a EA-H1N1 | |
| 650 | 4 | |a Eurasian avian-like virus | |
| 650 | 4 | |a clinical features | |
| 650 | 4 | |a genetic reassortant | |
| 650 | 4 | |a human origin | |
| 650 | 4 | |a infectivity | |
| 650 | 4 | |a influenza | |
| 650 | 4 | |a influenza A(H1N1) virus | |
| 650 | 4 | |a influenza virus | |
| 650 | 4 | |a novel virus | |
| 650 | 4 | |a reassortant virus | |
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| 700 | 1 | |a Zhong, Lili |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Lei |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Junfeng |e verfasserin |4 aut | |
| 700 | 1 | |a Xie, Yiran |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Fangcai |e verfasserin |4 aut | |
| 700 | 1 | |a Deng, Zhihong |e verfasserin |4 aut | |
| 700 | 1 | |a Feng, Hong |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Yiwei |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Shixiong |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Xin |e verfasserin |4 aut | |
| 700 | 1 | |a Zou, Xiaohui |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Xiaodan |e verfasserin |4 aut | |
| 700 | 1 | |a Bai, Tian |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Yongkun |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Zi |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Junhua |e verfasserin |4 aut | |
| 700 | 1 | |a Shu, Yuelong |e verfasserin |4 aut | |
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