Ex Vivo Lung Perfusion : Establishment and Operationalization in Iran
OBJECTIVES: Although the number of lung transplants is limited because of general shortage of organ donors, ex vivo lung perfusion is a novel method with 2 main benefits, including better evaluation of lung potential and recovery of injured lungs. The main aim of this study was to establish and operationalize ex vivo lung perfusion as the first experience in Iran.
MATERIALS AND METHODS: This was a prospective operational research study on 5 cases, including 1 pig from Vienna Medical University and 4 patients from Masih Daneshvari Hospital. All organ donations from brain dead donors were evaluated according to lung transplant or ex vivo lung perfusion criteria from May 2013 to July 2015 in Tehran, Iran. If a donor did not have any sign of severe chest trauma or pneumonia but had poor oxygenation due to possible atelectasis or neurogenic pulmonary edema, their lungs were included for ex vivo lung perfusion.
RESULTS: A successful trend in the difference between the pulmonary arterial Po2 and the left atrial Po2 was observed, as well as an increasing pattern in other functional parameters, including dynamic lung compliance and a decreasing trend in pulmonary vascular resistance.
CONCLUSIONS: These initial trials indicate that ex vivo lung perfusion can lead to remarkable progress in lung transplant in Iran. They also provide several important pieces of guidance for successful ex vivo lung perfusion, including the necessity of following standard lung retrieval procedures and monitoring temperature and pressure precisely. The development of novel methods can provide opportunities for further research studies on lungs of deceased donors and lead to undiscovered findings. By keeping this science up to date in Iran and developing such new and creative methods, we can reveal effective strategies to promote the quality of donor lungs to support patients on transplant wait lists.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
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| Enthalten in: |
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation - 15(2017), 1 vom: 25. Feb., Seite 82-88 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Shafaghi, Shadi [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 07.08.2017 Date Revised 17.08.2017 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.6002/ect.2015.0354 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM265465478 |
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| 500 | |a Date Completed 07.08.2017 | ||
| 500 | |a Date Revised 17.08.2017 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVES: Although the number of lung transplants is limited because of general shortage of organ donors, ex vivo lung perfusion is a novel method with 2 main benefits, including better evaluation of lung potential and recovery of injured lungs. The main aim of this study was to establish and operationalize ex vivo lung perfusion as the first experience in Iran | ||
| 520 | |a MATERIALS AND METHODS: This was a prospective operational research study on 5 cases, including 1 pig from Vienna Medical University and 4 patients from Masih Daneshvari Hospital. All organ donations from brain dead donors were evaluated according to lung transplant or ex vivo lung perfusion criteria from May 2013 to July 2015 in Tehran, Iran. If a donor did not have any sign of severe chest trauma or pneumonia but had poor oxygenation due to possible atelectasis or neurogenic pulmonary edema, their lungs were included for ex vivo lung perfusion | ||
| 520 | |a RESULTS: A successful trend in the difference between the pulmonary arterial Po2 and the left atrial Po2 was observed, as well as an increasing pattern in other functional parameters, including dynamic lung compliance and a decreasing trend in pulmonary vascular resistance | ||
| 520 | |a CONCLUSIONS: These initial trials indicate that ex vivo lung perfusion can lead to remarkable progress in lung transplant in Iran. They also provide several important pieces of guidance for successful ex vivo lung perfusion, including the necessity of following standard lung retrieval procedures and monitoring temperature and pressure precisely. The development of novel methods can provide opportunities for further research studies on lungs of deceased donors and lead to undiscovered findings. By keeping this science up to date in Iran and developing such new and creative methods, we can reveal effective strategies to promote the quality of donor lungs to support patients on transplant wait lists | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Abbasi Dezfuli, Azizollah |e verfasserin |4 aut | |
| 700 | 1 | |a Ansari Aval, Zahra |e verfasserin |4 aut | |
| 700 | 1 | |a Sheikhy, Kambiz |e verfasserin |4 aut | |
| 700 | 1 | |a Farzanegan, Behrooz |e verfasserin |4 aut | |
| 700 | 1 | |a Mortaz, Esmaeil |e verfasserin |4 aut | |
| 700 | 1 | |a Emami, Habib |e verfasserin |4 aut | |
| 700 | 1 | |a Aigner, Clemens |e verfasserin |4 aut | |
| 700 | 1 | |a Hosseini-Baharanchi, Fatemeh Sadat |e verfasserin |4 aut | |
| 700 | 1 | |a Najafizadeh, Katayoun |e verfasserin |4 aut | |
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