Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies
We have developed a novel real-time quaking-induced conversion RT-QuIC-based assay to detect alpha-synuclein aggregation in brain and cerebrospinal fluid from dementia with Lewy bodies and Parkinson's disease patients. This assay can detect alpha-synuclein aggregation in Dementia with Lewy bodies and Parkinson's disease cerebrospinal fluid with sensitivities of 92% and 95%, respectively, and with an overall specificity of 100% when compared to Alzheimer and control cerebrospinal fluid. Patients with neuropathologically confirmed tauopathies (progressive supranuclear palsy; corticobasal degeneration) gave negative results. These results suggest that RT-QuiC analysis of cerebrospinal fluid is potentially useful for the early clinical assessment of patients with alpha-synucleinopathies.
| Errataetall: | |
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| Medienart: |
Artikel |
| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:3 |
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| Enthalten in: |
Annals of clinical and translational neurology - 3(2016), 10 vom: 11. Okt., Seite 812-818 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Fairfoul, Graham [VerfasserIn] |
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| Themen: |
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| Anmerkungen: |
Date Revised 15.11.2023 published: Electronic-eCollection CommentIn: Mov Disord. 2017 Jan;32(1):106. - PMID 27896833 Citation Status PubMed-not-MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM265408822 |
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| 245 | 1 | 0 | |a Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies |
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| 500 | |a Date Revised 15.11.2023 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a CommentIn: Mov Disord. 2017 Jan;32(1):106. - PMID 27896833 | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a We have developed a novel real-time quaking-induced conversion RT-QuIC-based assay to detect alpha-synuclein aggregation in brain and cerebrospinal fluid from dementia with Lewy bodies and Parkinson's disease patients. This assay can detect alpha-synuclein aggregation in Dementia with Lewy bodies and Parkinson's disease cerebrospinal fluid with sensitivities of 92% and 95%, respectively, and with an overall specificity of 100% when compared to Alzheimer and control cerebrospinal fluid. Patients with neuropathologically confirmed tauopathies (progressive supranuclear palsy; corticobasal degeneration) gave negative results. These results suggest that RT-QuiC analysis of cerebrospinal fluid is potentially useful for the early clinical assessment of patients with alpha-synucleinopathies | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a McGuire, Lynne I |e verfasserin |4 aut | |
| 700 | 1 | |a Pal, Suvankar |e verfasserin |4 aut | |
| 700 | 1 | |a Ironside, James W |e verfasserin |4 aut | |
| 700 | 1 | |a Neumann, Juliane |e verfasserin |4 aut | |
| 700 | 1 | |a Christie, Sharon |e verfasserin |4 aut | |
| 700 | 1 | |a Joachim, Catherine |e verfasserin |4 aut | |
| 700 | 1 | |a Esiri, Margaret |e verfasserin |4 aut | |
| 700 | 1 | |a Evetts, Samuel G |e verfasserin |4 aut | |
| 700 | 1 | |a Rolinski, Michal |e verfasserin |4 aut | |
| 700 | 1 | |a Baig, Fahd |e verfasserin |4 aut | |
| 700 | 1 | |a Ruffmann, Claudio |e verfasserin |4 aut | |
| 700 | 1 | |a Wade-Martins, Richard |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Michele T M |e verfasserin |4 aut | |
| 700 | 1 | |a Parkkinen, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Green, Alison J E |e verfasserin |4 aut | |
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