Anti CCP Antibodies in Tuberculosis
INTRODUCTION: Anti-cyclic citrullinated peptide (anti-CCP) antibodies have been considered very specific for rheumatoid arthritis (RA). Some studies have shown that these antibodies can be positive in infectious diseases like TB, HIV, etc.
METHODS: Fifty patients of tuberculosis both pulmonary and extra-pulmonary were enrolled in the study from inpatient and outpatient departments from May 2012 to November 2013. Anti-CCP antibody test was done in all the patient by ELISA.
RESULTS: Thirty one were pulmonary and 17 were extra-pulmonary and two were disseminated extra-pulmonary TB. Of the 31 cases of pulmonary tuberculosis, 12 cases (38.7%) were positive for anti-CCP antibodies and 19 cases (61.3%) were negative for same. Of the 19 cases of extra-pulmonary tuberculosis, two cases (10.52%) were positive for anti-CCP antibodies and 17 cases (89.48%) were negative. Of the 31 patients of pulmonary TB, nine were sputum positive and 22 were negative. Of those with sputum positive five (55.56%) were positive for anti-CCP antibodies and those with sputum negative 7 cases (31.81%) were positive for anti-CCP antibodies.
CONCLUSIONS: Anti-CCP can be falsely positive in cases of tuberculosis. Positivity of anti-CCP antibodies for tuberculosis is more for pulmonary (more for sputum-positive than sputum-negative) than extra-pulmonary TB. Anti-CCP thus is not very specific for rheumatoid arthritis.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:64 |
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| Enthalten in: |
The Journal of the Association of Physicians of India - 64(2016), 5 vom: 07. Mai, Seite 26-28 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Londhey, Vikram [VerfasserIn] |
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| Themen: |
Anti-Citrullinated Protein Antibodies |
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| Anmerkungen: |
Date Completed 16.10.2018 Date Revised 16.10.2018 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM265260272 |
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| 100 | 1 | |a Londhey, Vikram |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Anti CCP Antibodies in Tuberculosis |
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| 500 | |a Date Revised 16.10.2018 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a INTRODUCTION: Anti-cyclic citrullinated peptide (anti-CCP) antibodies have been considered very specific for rheumatoid arthritis (RA). Some studies have shown that these antibodies can be positive in infectious diseases like TB, HIV, etc | ||
| 520 | |a METHODS: Fifty patients of tuberculosis both pulmonary and extra-pulmonary were enrolled in the study from inpatient and outpatient departments from May 2012 to November 2013. Anti-CCP antibody test was done in all the patient by ELISA | ||
| 520 | |a RESULTS: Thirty one were pulmonary and 17 were extra-pulmonary and two were disseminated extra-pulmonary TB. Of the 31 cases of pulmonary tuberculosis, 12 cases (38.7%) were positive for anti-CCP antibodies and 19 cases (61.3%) were negative for same. Of the 19 cases of extra-pulmonary tuberculosis, two cases (10.52%) were positive for anti-CCP antibodies and 17 cases (89.48%) were negative. Of the 31 patients of pulmonary TB, nine were sputum positive and 22 were negative. Of those with sputum positive five (55.56%) were positive for anti-CCP antibodies and those with sputum negative 7 cases (31.81%) were positive for anti-CCP antibodies | ||
| 520 | |a CONCLUSIONS: Anti-CCP can be falsely positive in cases of tuberculosis. Positivity of anti-CCP antibodies for tuberculosis is more for pulmonary (more for sputum-positive than sputum-negative) than extra-pulmonary TB. Anti-CCP thus is not very specific for rheumatoid arthritis | ||
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