Incidence and mortality of herpes simplex encephalitis in Denmark : A nationwide registry-based cohort study
Copyright © 2016 The British Infection Association. Published by Elsevier Ltd. All rights reserved..
OBJECTIVES: We aimed to investigate the incidence and mortality of herpes simplex encephalitis (HSE) in a nationwide cohort.
METHODS: From the Danish National Patient Registry, we identified all adults hospitalised with a first-time diagnosis of HSE in Denmark during 2004-2014. The HSE diagnoses were verified using medical records and microbiological data. Patients were followed for mortality through the Danish Civil Registry System. We estimated age-standardised incidence rates of HSE and 30-day, 60-day, and 1-year cumulative mortality. Furthermore, we assessed whether calendar year, age, gender, level of comorbidity, virus type, and department type was associated with HSE mortality.
RESULTS: We identified a total of 230 cases of HSE. Median age was 60.7 years (interquartile range: 49.3-71.6). The overall incidence rate was 4.64 cases per million population per year (95% confidence interval: 4.06-5.28). The cumulative mortality within 30 days, 60 days, and 1 year of the HSE admission was 8.3%, 11.3%, and 18.6%, respectively. Advanced age and presence of comorbidity were associated with increased 60-day and 1-year mortality.
CONCLUSIONS: This nationwide study of verified HSE found a higher incidence than reported in previous nationwide studies. Presence of comorbidity was identified as a novel adverse prognostic factor. Mortality rates following HSE remain high.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:74 |
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| Enthalten in: |
The Journal of infection - 74(2017), 1 vom: 01. Jan., Seite 42-49 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Jørgensen, Laura Krogh [VerfasserIn] |
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| Links: |
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| Themen: |
Comorbidity |
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| Anmerkungen: |
Date Completed 12.10.2017 Date Revised 27.06.2018 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jinf.2016.09.004 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM265116953 |
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| 100 | 1 | |a Jørgensen, Laura Krogh |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Incidence and mortality of herpes simplex encephalitis in Denmark |b A nationwide registry-based cohort study |
| 264 | 1 | |c 2017 | |
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| 500 | |a Date Completed 12.10.2017 | ||
| 500 | |a Date Revised 27.06.2018 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2016 The British Infection Association. Published by Elsevier Ltd. All rights reserved. | ||
| 520 | |a OBJECTIVES: We aimed to investigate the incidence and mortality of herpes simplex encephalitis (HSE) in a nationwide cohort | ||
| 520 | |a METHODS: From the Danish National Patient Registry, we identified all adults hospitalised with a first-time diagnosis of HSE in Denmark during 2004-2014. The HSE diagnoses were verified using medical records and microbiological data. Patients were followed for mortality through the Danish Civil Registry System. We estimated age-standardised incidence rates of HSE and 30-day, 60-day, and 1-year cumulative mortality. Furthermore, we assessed whether calendar year, age, gender, level of comorbidity, virus type, and department type was associated with HSE mortality | ||
| 520 | |a RESULTS: We identified a total of 230 cases of HSE. Median age was 60.7 years (interquartile range: 49.3-71.6). The overall incidence rate was 4.64 cases per million population per year (95% confidence interval: 4.06-5.28). The cumulative mortality within 30 days, 60 days, and 1 year of the HSE admission was 8.3%, 11.3%, and 18.6%, respectively. Advanced age and presence of comorbidity were associated with increased 60-day and 1-year mortality | ||
| 520 | |a CONCLUSIONS: This nationwide study of verified HSE found a higher incidence than reported in previous nationwide studies. Presence of comorbidity was identified as a novel adverse prognostic factor. Mortality rates following HSE remain high | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Comorbidity | |
| 650 | 4 | |a Epidemiology | |
| 650 | 4 | |a Herpes simplex encephalitis | |
| 650 | 4 | |a Herpes simplex virus | |
| 650 | 4 | |a Incidence | |
| 650 | 4 | |a Mortality | |
| 650 | 4 | |a Prognosis | |
| 650 | 4 | |a Viral encephalitis | |
| 700 | 1 | |a Dalgaard, Lars Skov |e verfasserin |4 aut | |
| 700 | 1 | |a Østergaard, Lars Jørgen |e verfasserin |4 aut | |
| 700 | 1 | |a Nørgaard, Mette |e verfasserin |4 aut | |
| 700 | 1 | |a Mogensen, Trine Hyrup |e verfasserin |4 aut | |
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