Sonographic measurement of Achilles tendon thickness in seronegative spondyloarthropathies
OBJECTIVE: To define the best cut-off value for identifying Achilles tendon thickening using ultrasound (US) in patients with spondyloarthropathies (SpA) and to assess its diagnostic utility in comparison with different cut-off values used in the literature.
MATERIAL AND METHODS: One-hundred and one subjects (55 SpA patients and 46 age and body mass index ((BMI)-matched healthy controls (HC)) were investigated. US was performed using a MyLab70 US system (Esaote Biomedica, Genoa, Italy) with a linear probe (6-18 MHz). Three images per Achilles enthesis were stored and the antero-posterior thickness of the enthesis was measured at the level of the Achilles tendon deeper margin insertion into the calcaneal bone on the longitudinal median scan. The best cut-off value for each gender was determined by ROC curve analysis and compared to the other cut-off values in the literature: 1) 5.29 mm for both genders, and 2) 5.5 mm for females and 6.2 mm for males. The number of measurements exceeding the cut-off values as well as sensitivity (SE), specificity (SP), positive (PPV) and negative (NPV) predictive values were calculated.
RESULTS: A significant difference was observed for Achilles enthesis thickness between genders (mean±SD: 4.6±0.7 mm in males vs. 4.0±0.8 mm in females, p<0.00) and between SpA patients and HC (mean±SD: 4.4±0.8 mm in SpA patients vs. 4.0±0.8 mm in HC, p<0.001). The ROC curve analysis revealed the best cut-off value to be 3.7 mm for females and 4.8 mm for males (SE: 43-70%, SP: 59-85%, PPV: 66-79%, NPV: 54-63%). Previously reported cut-off values were found to have high SP (91-98%) but very low SE (2-11%).
CONCLUSION: Achilles tendon thickness differs between genders; thus, it is crucial to refer to normal values that are specific for gender. High cut-off values, as previously suggested, showed very low SE in the current study. When Achilles enthesis thickening is used for the purpose of screening enthesitis in SpA patients, a lower cut-off value has a higher SE with slightly worse SP, PPV and NPVs.
Medienart: |
Artikel |
---|
Erscheinungsjahr: |
2014 |
---|---|
Erschienen: |
2014 |
Enthalten in: |
Zur Gesamtaufnahme - volume:1 |
---|---|
Enthalten in: |
European journal of rheumatology - 1(2014), 1 vom: 19. März, Seite 7-10 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Aydın, Sibel Zehra [VerfasserIn] |
---|
Themen: |
Achilles tendon thickness |
---|
Anmerkungen: |
Date Revised 01.10.2020 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
---|
Förderinstitution / Projekttitel: |
|
---|
PPN (Katalog-ID): |
NLM265040558 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM265040558 | ||
003 | DE-627 | ||
005 | 20231224211419.0 | ||
007 | tu | ||
008 | 231224s2014 xx ||||| 00| ||eng c | ||
028 | 5 | 2 | |a pubmed24n0883.xml |
035 | |a (DE-627)NLM265040558 | ||
035 | |a (NLM)27708863 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Aydın, Sibel Zehra |e verfasserin |4 aut | |
245 | 1 | 0 | |a Sonographic measurement of Achilles tendon thickness in seronegative spondyloarthropathies |
264 | 1 | |c 2014 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
338 | |a Band |b nc |2 rdacarrier | ||
500 | |a Date Revised 01.10.2020 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status PubMed-not-MEDLINE | ||
520 | |a OBJECTIVE: To define the best cut-off value for identifying Achilles tendon thickening using ultrasound (US) in patients with spondyloarthropathies (SpA) and to assess its diagnostic utility in comparison with different cut-off values used in the literature | ||
520 | |a MATERIAL AND METHODS: One-hundred and one subjects (55 SpA patients and 46 age and body mass index ((BMI)-matched healthy controls (HC)) were investigated. US was performed using a MyLab70 US system (Esaote Biomedica, Genoa, Italy) with a linear probe (6-18 MHz). Three images per Achilles enthesis were stored and the antero-posterior thickness of the enthesis was measured at the level of the Achilles tendon deeper margin insertion into the calcaneal bone on the longitudinal median scan. The best cut-off value for each gender was determined by ROC curve analysis and compared to the other cut-off values in the literature: 1) 5.29 mm for both genders, and 2) 5.5 mm for females and 6.2 mm for males. The number of measurements exceeding the cut-off values as well as sensitivity (SE), specificity (SP), positive (PPV) and negative (NPV) predictive values were calculated | ||
520 | |a RESULTS: A significant difference was observed for Achilles enthesis thickness between genders (mean±SD: 4.6±0.7 mm in males vs. 4.0±0.8 mm in females, p<0.00) and between SpA patients and HC (mean±SD: 4.4±0.8 mm in SpA patients vs. 4.0±0.8 mm in HC, p<0.001). The ROC curve analysis revealed the best cut-off value to be 3.7 mm for females and 4.8 mm for males (SE: 43-70%, SP: 59-85%, PPV: 66-79%, NPV: 54-63%). Previously reported cut-off values were found to have high SP (91-98%) but very low SE (2-11%) | ||
520 | |a CONCLUSION: Achilles tendon thickness differs between genders; thus, it is crucial to refer to normal values that are specific for gender. High cut-off values, as previously suggested, showed very low SE in the current study. When Achilles enthesis thickening is used for the purpose of screening enthesitis in SpA patients, a lower cut-off value has a higher SE with slightly worse SP, PPV and NPVs | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Achilles tendon thickness | |
650 | 4 | |a enthesitis | |
650 | 4 | |a seronegative spondyloarthropathies | |
650 | 4 | |a ultrasound | |
700 | 1 | |a Filippucci, Emilio |e verfasserin |4 aut | |
700 | 1 | |a Atagündüz, Pamir |e verfasserin |4 aut | |
700 | 1 | |a Yavuz, Şule |e verfasserin |4 aut | |
700 | 1 | |a Grassi, Walter |e verfasserin |4 aut | |
700 | 1 | |a Direskeneli, Haner |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t European journal of rheumatology |d 2014 |g 1(2014), 1 vom: 19. März, Seite 7-10 |w (DE-627)NLM265040523 |x 2147-9720 |7 nnns |
773 | 1 | 8 | |g volume:1 |g year:2014 |g number:1 |g day:19 |g month:03 |g pages:7-10 |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 1 |j 2014 |e 1 |b 19 |c 03 |h 7-10 |