Intraperitoneal Meropenem for Polymicrobial Peritoneal Dialysis-Related Peritonitis
Copyright © 2016 International Society for Peritoneal Dialysis..
With the current rise in multiresistant gram-negative bacteria, carbapenems are more frequently used. Surprisingly, limited data exist on the pharmacokinetics of meropenem in peritoneal dialysis (PD)-related peritonitis. We report on the pharmacokinetics of repeated intraperitoneal (IP) meropenem during 21 days as treatment for polymicrobial multiresistent PD-related peritonitis.Our current report supports daily doses of 125 mg/L intraperitoneal meropenem in all bags as an effective and safe modality in the treatment of PD-associated peritonitis with multiresistant microorganisms. No signs of over- or underdosing were found based on serial drug concentration measurements at fixed time points up to 21 days.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:36 |
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| Enthalten in: |
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis - 36(2016), 5 vom: 10., Seite 572-3 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
de Fijter, Caroline W H [VerfasserIn] |
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| Links: |
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| Themen: |
Anti-Bacterial Agents |
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| Anmerkungen: |
Date Completed 11.12.2017 Date Revised 09.01.2020 published: Print Citation Status MEDLINE |
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| doi: |
10.3747/pdi.2016.00023 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM264614291 |
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| 520 | |a Copyright © 2016 International Society for Peritoneal Dialysis. | ||
| 520 | |a With the current rise in multiresistant gram-negative bacteria, carbapenems are more frequently used. Surprisingly, limited data exist on the pharmacokinetics of meropenem in peritoneal dialysis (PD)-related peritonitis. We report on the pharmacokinetics of repeated intraperitoneal (IP) meropenem during 21 days as treatment for polymicrobial multiresistent PD-related peritonitis.Our current report supports daily doses of 125 mg/L intraperitoneal meropenem in all bags as an effective and safe modality in the treatment of PD-associated peritonitis with multiresistant microorganisms. No signs of over- or underdosing were found based on serial drug concentration measurements at fixed time points up to 21 days | ||
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| 700 | 1 | |a Franssen, Eric |e verfasserin |4 aut | |
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