Association of Interleukin-23 Receptor Gene Single Nucleotide Polymorphisms with Ankylosing Spondylitis
© 2016 by the Association of Clinical Scientists, Inc..
OBJECTIVE: It has been shown previously that the IL-23 receptor (IL-23R) variants are associated with ankylosing spondylitis (AS). It is unknown whether IL-23R is associated with AS in the Chinese population. The present study was performed to examine the association of IL-23R gene polymorphisms with susceptibility to AS in the Chinese population.
METHODS: A total of 157 Chinese Han patients with AS and 150 ethnically matched healthy controls were enrolled. All patients were diagnosed with AS according to the modified New York criteria. 8 single nucleotide polymorphisms (SNPs) of the IL-23R gene cluster were genotyped.
RESULTS: None of the 8 IL-23R SNPs were found to be associated with AS in the Chinese population.
CONCLUSION: The association of IL-23R and AS that is seen in Caucasian patients with AS is not present in Chinese patients with AS.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:46 |
|---|---|
| Enthalten in: |
Annals of clinical and laboratory science - 46(2016), 5 vom: 20. Sept., Seite 470-3 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Su, Song-Sen [VerfasserIn] |
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| Themen: |
Ankylosing spondylitis |
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| Anmerkungen: |
Date Completed 13.01.2017 Date Revised 13.01.2017 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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NLM264524039 |
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| 100 | 1 | |a Su, Song-Sen |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Association of Interleukin-23 Receptor Gene Single Nucleotide Polymorphisms with Ankylosing Spondylitis |
| 264 | 1 | |c 2016 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
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| 500 | |a Date Completed 13.01.2017 | ||
| 500 | |a Date Revised 13.01.2017 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2016 by the Association of Clinical Scientists, Inc. | ||
| 520 | |a OBJECTIVE: It has been shown previously that the IL-23 receptor (IL-23R) variants are associated with ankylosing spondylitis (AS). It is unknown whether IL-23R is associated with AS in the Chinese population. The present study was performed to examine the association of IL-23R gene polymorphisms with susceptibility to AS in the Chinese population | ||
| 520 | |a METHODS: A total of 157 Chinese Han patients with AS and 150 ethnically matched healthy controls were enrolled. All patients were diagnosed with AS according to the modified New York criteria. 8 single nucleotide polymorphisms (SNPs) of the IL-23R gene cluster were genotyped | ||
| 520 | |a RESULTS: None of the 8 IL-23R SNPs were found to be associated with AS in the Chinese population | ||
| 520 | |a CONCLUSION: The association of IL-23R and AS that is seen in Caucasian patients with AS is not present in Chinese patients with AS | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a IL-23R | |
| 650 | 4 | |a ankylosing spondylitis | |
| 650 | 4 | |a genetics | |
| 650 | 7 | |a IL23R protein, human |2 NLM | |
| 650 | 7 | |a Receptors, Interleukin |2 NLM | |
| 700 | 1 | |a Wang, Su-Li |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Liang-Jing |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Ling |e verfasserin |4 aut | |
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