Assessment of light stability of drugs in blood and plasma
AIM: A procedure was developed for the assessment of photochemical stability of drugs in blood and plasma under standardized conditions. The procedure avoids a variable outcome of photochemical stability experiments and tests relevant worst case conditions so that unnecessary light protection is avoided. Results/methodology: Blood and plasma were spiked with a mixture of drugs and incubated in a Suntest CPS(+), in the laboratory on the bench and near the window on a sunny summer day. The results were compared.
DISCUSSION/CONCLUSION: No protection from light, limited protection from light and full protection from light are advised for drugs that are stable in plasma in the Suntest CPS(+) at 250 W/m(2) for at least 30 min, for 5-30 min and for <5 min, respectively.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:8 |
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| Enthalten in: |
Bioanalysis - 8(2016), 19 vom: 28. Okt., Seite 2007-21 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
de Vries, Ronald [VerfasserIn] |
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| Links: |
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| Themen: |
Bioanalysis |
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| Anmerkungen: |
Date Completed 24.01.2017 Date Revised 24.01.2017 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.4155/bio-2016-0109 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM264194799 |
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| 245 | 1 | 0 | |a Assessment of light stability of drugs in blood and plasma |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a AIM: A procedure was developed for the assessment of photochemical stability of drugs in blood and plasma under standardized conditions. The procedure avoids a variable outcome of photochemical stability experiments and tests relevant worst case conditions so that unnecessary light protection is avoided. Results/methodology: Blood and plasma were spiked with a mixture of drugs and incubated in a Suntest CPS(+), in the laboratory on the bench and near the window on a sunny summer day. The results were compared | ||
| 520 | |a DISCUSSION/CONCLUSION: No protection from light, limited protection from light and full protection from light are advised for drugs that are stable in plasma in the Suntest CPS(+) at 250 W/m(2) for at least 30 min, for 5-30 min and for <5 min, respectively | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Dillen, Lieve |e verfasserin |4 aut | |
| 700 | 1 | |a Sips, Luc |e verfasserin |4 aut | |
| 700 | 1 | |a Van Roosbroek, Dirk |e verfasserin |4 aut | |
| 700 | 1 | |a Verhaeghe, Tom |e verfasserin |4 aut | |
| 700 | 1 | |a Timmerman, Philip |e verfasserin |4 aut | |
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