Month of birth, HLA-DRB1*15 locus and risk of multiple sclerosis in offspring
INTRODUCTION: A relationship among April births, HLA-DRB1*15:01 genotype and risk of multiple sclerosis (MS) has been described. We aim to determine this association in our cohort of Spanish MS patients.
SUBJECTS AND METHODS: We genotyped HLA-DRB1*15:01 allele in 326 MS patients and 226 controls (non-neurological disease patients) by SSP-PCR and compared month of birth with local births during the same period.
RESULTS: MS patients carrying HLA-DRB1*15 allele were more frequently born in December (10.3% HLA-DRB1*15+ vs. 3.8% HLA-DRB1*15-; p = 0.019). Controls carrying HLA-DRB1*15 allele were less frequently born in December than non-carrier controls (0% HLA-DRB1*15+ vs. 10.3% HLA-DRB1*15-; p = 0.028). Thus, December was confirmed as the common month of birth for HLA-DRB1*15-non-carrier controls and MS HLA-DRB1*15-carrier patients.
CONCLUSIONS: Month of birth, HLA-DRB1 genotype and risk of MS are associated. In Spain, this association was found in December, supporting the potential interaction of a seasonal risk factor in winter, inside/close to HLA-DRB1*15 locus, during pregnancy or after birth.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:63 |
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| Enthalten in: |
Revista de neurologia - 63(2016), 5 vom: 01. Sept., Seite 201-5 |
| Sprache: |
Englisch |
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| Weiterer Titel: |
Mes de nacimiento, HLA-DRB1 y riesgo de esclerosis multiple en la descendencia |
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| Beteiligte Personen: |
Guijarro-Castro, C [VerfasserIn] |
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| Themen: |
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| Anmerkungen: |
Date Completed 09.03.2018 Date Revised 02.12.2018 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM263830268 |
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| 245 | 1 | 0 | |a Month of birth, HLA-DRB1*15 locus and risk of multiple sclerosis in offspring |
| 246 | 3 | 3 | |a Mes de nacimiento, HLA-DRB1 y riesgo de esclerosis multiple en la descendencia |
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| 500 | |a Date Completed 09.03.2018 | ||
| 500 | |a Date Revised 02.12.2018 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a INTRODUCTION: A relationship among April births, HLA-DRB1*15:01 genotype and risk of multiple sclerosis (MS) has been described. We aim to determine this association in our cohort of Spanish MS patients | ||
| 520 | |a SUBJECTS AND METHODS: We genotyped HLA-DRB1*15:01 allele in 326 MS patients and 226 controls (non-neurological disease patients) by SSP-PCR and compared month of birth with local births during the same period | ||
| 520 | |a RESULTS: MS patients carrying HLA-DRB1*15 allele were more frequently born in December (10.3% HLA-DRB1*15+ vs. 3.8% HLA-DRB1*15-; p = 0.019). Controls carrying HLA-DRB1*15 allele were less frequently born in December than non-carrier controls (0% HLA-DRB1*15+ vs. 10.3% HLA-DRB1*15-; p = 0.028). Thus, December was confirmed as the common month of birth for HLA-DRB1*15-non-carrier controls and MS HLA-DRB1*15-carrier patients | ||
| 520 | |a CONCLUSIONS: Month of birth, HLA-DRB1 genotype and risk of MS are associated. In Spain, this association was found in December, supporting the potential interaction of a seasonal risk factor in winter, inside/close to HLA-DRB1*15 locus, during pregnancy or after birth | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Sanchez-Zapardiel, E |e verfasserin |4 aut | |
| 700 | 1 | |a Munoz, D |e verfasserin |4 aut | |
| 700 | 1 | |a Fernandez, O |e verfasserin |4 aut | |
| 700 | 1 | |a Leyva, L |e verfasserin |4 aut | |
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