Endothelin-1 Gene Polymorphism and Its Level Predict the Risk of Venous Thromboembolism in Male Indian Population
OBJECTIVES: Genes related to endothelial function are responsible for the regulation of vascular functions.
AIM: The aim of this study is to investigate whether endothelial gene-associated polymorphism and their plasma levels can be used to predict the risk for venous thromboembolism (VTE).
METHODS: We studied 133 patients with VTE and 164 healthy controls. Endothelin (EDN) G8002A, EDN T1370G, EDN 3A/4A, eNOSG894T, angiotensin-converting enzyme I/D, vascular endothelial growth factor C936T, and endothelial cell protein C receptor A6936G polymorphism was genotyped by restriction fragment length polymorphism. Plasma levels of endothelin 1 (EDN1), endothelial nitric oxide synthase, and angiotensin-converting enzyme were measured by enzyme-linked immunoassay kit.
RESULTS: The genotype and allele frequency between control and patients with VTE were significantly altered only for EDN T1370G polymorphism. The plasma EDN1 concentration was relatively higher in patients with VTE ( P = .0017) compared to healthy controls and showed an association with the EDN1 gene polymorphism in male Indian population. Logistic regression model analysis for EDN T1370G indicated a significant association between EDN G allele and occurrence of VTE.
CONCLUSION: The EDN1 gene polymorphism may play a significant role in predicting individual's susceptibility toward VTE and its clinical progression.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:23 |
|---|---|
| Enthalten in: |
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis - 23(2017), 5 vom: 15. Juli, Seite 429-437 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kumari, Babita [VerfasserIn] |
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| Links: |
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| Themen: |
Endothelin-1 |
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| Anmerkungen: |
Date Completed 09.03.2018 Date Revised 09.03.2018 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1177/1076029616661416 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM263032957 |
|---|
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| 245 | 1 | 0 | |a Endothelin-1 Gene Polymorphism and Its Level Predict the Risk of Venous Thromboembolism in Male Indian Population |
| 264 | 1 | |c 2017 | |
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| 500 | |a Date Completed 09.03.2018 | ||
| 500 | |a Date Revised 09.03.2018 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVES: Genes related to endothelial function are responsible for the regulation of vascular functions | ||
| 520 | |a AIM: The aim of this study is to investigate whether endothelial gene-associated polymorphism and their plasma levels can be used to predict the risk for venous thromboembolism (VTE) | ||
| 520 | |a METHODS: We studied 133 patients with VTE and 164 healthy controls. Endothelin (EDN) G8002A, EDN T1370G, EDN 3A/4A, eNOSG894T, angiotensin-converting enzyme I/D, vascular endothelial growth factor C936T, and endothelial cell protein C receptor A6936G polymorphism was genotyped by restriction fragment length polymorphism. Plasma levels of endothelin 1 (EDN1), endothelial nitric oxide synthase, and angiotensin-converting enzyme were measured by enzyme-linked immunoassay kit | ||
| 520 | |a RESULTS: The genotype and allele frequency between control and patients with VTE were significantly altered only for EDN T1370G polymorphism. The plasma EDN1 concentration was relatively higher in patients with VTE ( P = .0017) compared to healthy controls and showed an association with the EDN1 gene polymorphism in male Indian population. Logistic regression model analysis for EDN T1370G indicated a significant association between EDN G allele and occurrence of VTE | ||
| 520 | |a CONCLUSION: The EDN1 gene polymorphism may play a significant role in predicting individual's susceptibility toward VTE and its clinical progression | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a endothelium | |
| 650 | 4 | |a single nucleotide polymorphism | |
| 650 | 4 | |a venous thromboembolism | |
| 650 | 7 | |a Endothelin-1 |2 NLM | |
| 700 | 1 | |a Prabhakar, Amit |e verfasserin |4 aut | |
| 700 | 1 | |a Sahu, Anita |e verfasserin |4 aut | |
| 700 | 1 | |a Chatterjee, Tathagata |e verfasserin |4 aut | |
| 700 | 1 | |a Tyagi, Tarun |e verfasserin |4 aut | |
| 700 | 1 | |a Gupta, Neha |e verfasserin |4 aut | |
| 700 | 1 | |a Nair, Velu |e verfasserin |4 aut | |
| 700 | 1 | |a Ashraf, Mohammad Zahid |e verfasserin |4 aut | |
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