Inherited thrombophilia in women with poor aPL-related obstetric history : prevalence and outcomes. Survey of 208 cases from the European Registry on Obstetric Antiphospholipid Syndrome cohort
© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd..
AIM: To analyse the prevalence and effects of inherited thrombophilic disorders (ITD) on maternal-foetal outcomes in cases of antiphospholipid antibody related to obstetric complications.
METHODS: Women with obstetric complaints who tested positive for aPL and with inherited thrombophilia were prospectively and retrospectively included.
RESULTS: ITD data were available in 208 of 338: 147 had obstetric antiphospholipid syndrome (OAPS) and 61 aPL-related obstetric morbidity (OMAPS). 24.1% had ITD. Laboratory categories I and IIa were more related to OAPS-ITD and IIb and IIc to OMAPS-ITD. No significant differences in obstetric complaints were observed. Regarding ITD carriers, treatment rates were higher in OAPS than in OMAPS for LMWH and LDA plus LMWH (P=.002).
CONCLUSION: Cases with aPL-related OAPS/OMAPS showed no differences in maternal-foetal outcomes regardless of the presence of one ITD. Maternal thrombotic risk was low, with ITD-positive cases included. Registry data concur with Sydney criteria, whereby aPL-ITD-positive patients are classified as having antiphospholipid syndrome.
| Errataetall: |
CommentIn: Am J Reprod Immunol. 2017 Jan;77(1):null. - PMID 27862565 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:76 |
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| Enthalten in: |
American journal of reproductive immunology (New York, N.Y. : 1989) - 76(2016), 2 vom: 11. Aug., Seite 164-71 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Alijotas-Reig, Jaume [VerfasserIn] |
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| Links: |
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| Themen: |
Antiphospholipid antibody |
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| Anmerkungen: |
Date Completed 13.12.2017 Date Revised 03.04.2018 published: Print CommentIn: Am J Reprod Immunol. 2017 Jan;77(1):null. - PMID 27862565 Citation Status MEDLINE |
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| doi: |
10.1111/aji.12534 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM262284952 |
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| 041 | |a eng | ||
| 100 | 1 | |a Alijotas-Reig, Jaume |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Inherited thrombophilia in women with poor aPL-related obstetric history |b prevalence and outcomes. Survey of 208 cases from the European Registry on Obstetric Antiphospholipid Syndrome cohort |
| 264 | 1 | |c 2016 | |
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| 500 | |a Date Completed 13.12.2017 | ||
| 500 | |a Date Revised 03.04.2018 | ||
| 500 | |a published: Print | ||
| 500 | |a CommentIn: Am J Reprod Immunol. 2017 Jan;77(1):null. - PMID 27862565 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. | ||
| 520 | |a AIM: To analyse the prevalence and effects of inherited thrombophilic disorders (ITD) on maternal-foetal outcomes in cases of antiphospholipid antibody related to obstetric complications | ||
| 520 | |a METHODS: Women with obstetric complaints who tested positive for aPL and with inherited thrombophilia were prospectively and retrospectively included | ||
| 520 | |a RESULTS: ITD data were available in 208 of 338: 147 had obstetric antiphospholipid syndrome (OAPS) and 61 aPL-related obstetric morbidity (OMAPS). 24.1% had ITD. Laboratory categories I and IIa were more related to OAPS-ITD and IIb and IIc to OMAPS-ITD. No significant differences in obstetric complaints were observed. Regarding ITD carriers, treatment rates were higher in OAPS than in OMAPS for LMWH and LDA plus LMWH (P=.002) | ||
| 520 | |a CONCLUSION: Cases with aPL-related OAPS/OMAPS showed no differences in maternal-foetal outcomes regardless of the presence of one ITD. Maternal thrombotic risk was low, with ITD-positive cases included. Registry data concur with Sydney criteria, whereby aPL-ITD-positive patients are classified as having antiphospholipid syndrome | ||
| 650 | 4 | |a Clinical Trial | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a antiphospholipid antibody | |
| 650 | 4 | |a inherited thrombophilia | |
| 650 | 4 | |a obstetric outcome | |
| 650 | 4 | |a thrombosis | |
| 650 | 4 | |a treatment | |
| 700 | 1 | |a Ferrer-Oliveras, Raquel |e verfasserin |4 aut | |
| 700 | 1 | |a Esteve-Valverde, Enrique |e verfasserin |4 aut | |
| 700 | 1 | |a Ruffatti, Amelia |e verfasserin |4 aut | |
| 700 | 1 | |a Tincani, Angela |e verfasserin |4 aut | |
| 700 | 1 | |a Lefkou, Elmina |e verfasserin |4 aut | |
| 700 | 1 | |a Bertero, Maria Tiziana |e verfasserin |4 aut | |
| 700 | 1 | |a Espinosa, Gerard |e verfasserin |4 aut | |
| 700 | 1 | |a Coloma, Emmanuel |e verfasserin |4 aut | |
| 700 | 1 | |a de Carolis, Sara |e verfasserin |4 aut | |
| 700 | 1 | |a Rovere-Querini, Patrizia |e verfasserin |4 aut | |
| 700 | 1 | |a Canti, Valentina |e verfasserin |4 aut | |
| 700 | 1 | |a Picardo, Elisa |e verfasserin |4 aut | |
| 700 | 1 | |a Fredi, Micaela |e verfasserin |4 aut | |
| 700 | 1 | |a Mekinian, Arsene |e verfasserin |4 aut | |
| 700 | 0 | |a EUROAPS Study Group |e verfasserin |4 aut | |
| 700 | 1 | |a Kuzenko, Anna |e investigator |4 oth | |
| 700 | 1 | |a Ruano, Anna |e investigator |4 oth | |
| 700 | 1 | |a Del Ross, Teresa |e investigator |4 oth | |
| 700 | 1 | |a Melnychuk, Taisiia |e investigator |4 oth | |
| 700 | 1 | |a Lundelin, Krista |e investigator |4 oth | |
| 700 | 1 | |a Llurba, Elisa |e investigator |4 oth | |
| 700 | 1 | |a Cervera, Ricard |e investigator |4 oth | |
| 700 | 1 | |a Toth, Bettina |e investigator |4 oth | |
| 700 | 1 | |a Saez-Comet, Luis |e investigator |4 oth | |
| 700 | 1 | |a Bremme, Katharina |e investigator |4 oth | |
| 700 | 1 | |a Mayer-Pickel, Karoline |e investigator |4 oth | |
| 700 | 1 | |a Gil-Aguado, Antonio |e investigator |4 oth | |
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