Evaluation of dual trigger with gonadotropin-releasing hormone agonist and human chorionic gonadotropin in improving oocyte maturity rates : A prospective randomized study
BACKGROUND: Mature oocytes are prerequisite for achieving the process of in vitro fertilization. Human chorionic gonadotropin (hCG) is the standard trigger used for stimulating ovulation but is associated with ovarian hyperstimulation syndrome (OHSS). Gonadotropin-releasing hormone agonist trigger achieves oocyte maturation and lowers the incidence of OHSS, but it has limitations of higher pregnancy loss rate and miscarriage rates. Coadministration of both hormones is found to improve the pregnancy rates and the number of mature oocytes retrieved. We aimed to assess if the dual trigger is better than the conventional hCG in triggering oocyte maturation.
METHODOLOGY: The study included 76 female patients aged 24-43 years who were randomly divided into two groups with 38 patients in each arm. The study included patients with antimullerian hormone (AMH) <4 ng/ml, antral follicle counts (AFCs)/ovary <12. The study excluded high responders-AMH >4 ng/ml and AFC/ovary >12 to avoid OHSS risk with hCG trigger.
RESULTS: The study showed statistically insignificant differences between dual group versus hCG group in terms of the number of oocytes retrieved (10.0 ± 5.6 vs. 8.7 ± 5.0; P = 0.2816), the number of mature oocytes recovered (8.4 ± 5.0 vs. 7.2 ± 4.0; P = 0.2588), fertilization rate (5.9 ± 4.2 vs. 5.6 ± 3.3; P = 0.7390), and the number of usable embryos on day 3 (4.0 ± 3.0 vs. 4.0 ± 2.4; P = 0.8991).
CONCLUSION: The dual trigger is equivalent to hCG in triggering oocyte maturation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
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| Enthalten in: |
Journal of human reproductive sciences - 9(2016), 2 vom: 19. Apr., Seite 101-6 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mahajan, Nalini [VerfasserIn] |
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| Links: |
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| Themen: |
Dual trigger |
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| Anmerkungen: |
Date Completed 06.07.2016 Date Revised 01.10.2020 published: Print Citation Status PubMed-not-MEDLINE |
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| doi: |
10.4103/0974-1208.183506 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM262099543 |
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| 100 | 1 | |a Mahajan, Nalini |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Evaluation of dual trigger with gonadotropin-releasing hormone agonist and human chorionic gonadotropin in improving oocyte maturity rates |b A prospective randomized study |
| 264 | 1 | |c 2016 | |
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| 500 | |a Date Completed 06.07.2016 | ||
| 500 | |a Date Revised 01.10.2020 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a BACKGROUND: Mature oocytes are prerequisite for achieving the process of in vitro fertilization. Human chorionic gonadotropin (hCG) is the standard trigger used for stimulating ovulation but is associated with ovarian hyperstimulation syndrome (OHSS). Gonadotropin-releasing hormone agonist trigger achieves oocyte maturation and lowers the incidence of OHSS, but it has limitations of higher pregnancy loss rate and miscarriage rates. Coadministration of both hormones is found to improve the pregnancy rates and the number of mature oocytes retrieved. We aimed to assess if the dual trigger is better than the conventional hCG in triggering oocyte maturation | ||
| 520 | |a METHODOLOGY: The study included 76 female patients aged 24-43 years who were randomly divided into two groups with 38 patients in each arm. The study included patients with antimullerian hormone (AMH) <4 ng/ml, antral follicle counts (AFCs)/ovary <12. The study excluded high responders-AMH >4 ng/ml and AFC/ovary >12 to avoid OHSS risk with hCG trigger | ||
| 520 | |a RESULTS: The study showed statistically insignificant differences between dual group versus hCG group in terms of the number of oocytes retrieved (10.0 ± 5.6 vs. 8.7 ± 5.0; P = 0.2816), the number of mature oocytes recovered (8.4 ± 5.0 vs. 7.2 ± 4.0; P = 0.2588), fertilization rate (5.9 ± 4.2 vs. 5.6 ± 3.3; P = 0.7390), and the number of usable embryos on day 3 (4.0 ± 3.0 vs. 4.0 ± 2.4; P = 0.8991) | ||
| 520 | |a CONCLUSION: The dual trigger is equivalent to hCG in triggering oocyte maturation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Dual trigger | |
| 650 | 4 | |a gonadotropin-releasing hormone agonist trigger | |
| 650 | 4 | |a oocyte maturation | |
| 700 | 1 | |a Sharma, Shilpa |e verfasserin |4 aut | |
| 700 | 1 | |a Arora, Puneet Rana |e verfasserin |4 aut | |
| 700 | 1 | |a Gupta, Shalu |e verfasserin |4 aut | |
| 700 | 1 | |a Rani, Kumkum |e verfasserin |4 aut | |
| 700 | 1 | |a Naidu, Padmaja |e verfasserin |4 aut | |
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