Differences in viral load among human respiratory syncytial virus genotypes in hospitalized children with severe acute respiratory infections in the Philippines
BACKGROUND: Human respiratory syncytial virus (HRSV) is a leading viral etiologic agent of pediatric lower respiratory infections, including bronchiolitis and pneumonia. Two antigenic subgroups, HRSV-A and B, each contain several genotypes. While viral load may vary among HRSV genotypes and affect the clinical course of disease, data are scarce regarding the actual differences among genotypes. Therefore, this study estimated and compared viral load among NA1 and ON1 genotypes of HRSV-A and BA9 of HRSV-B. ON1 is a newly emerged genotype with a 72-nucleotide duplication in the G gene as observed previously with BA genotypes in HRSV-B.
FINDINGS: Children <5 years of age with an initial diagnosis of severe or very severe pneumonia at a hospital in the Philippines from September 2012 to December 2013 were enrolled. HRSV genotypes were determined and the viral load measured from nasopharyngeal swabs (NPS). The viral load of HRSV genotype NA1 were significantly higher than those of ON1 and BA9. Regression analysis showed that both genotype NA1 and younger age were significantly associated with high HRSV viral load.
CONCLUSIONS: The viral load of NA1 was higher than that of ON1 and BA9 in NPS samples. HRSV genotypes may be associated with HRSV viral load. The reasons and clinical impacts of these differences in viral load among HRSV genotypes require further evaluation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
Virology journal - 13(2016) vom: 27. Juni, Seite 113 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kadji, Francois Marie Ngako [VerfasserIn] |
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| Links: |
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| Themen: |
Children |
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| Anmerkungen: |
Date Completed 31.07.2017 Date Revised 13.11.2018 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1186/s12985-016-0565-8 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM261819356 |
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| 100 | 1 | |a Kadji, Francois Marie Ngako |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Differences in viral load among human respiratory syncytial virus genotypes in hospitalized children with severe acute respiratory infections in the Philippines |
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| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Human respiratory syncytial virus (HRSV) is a leading viral etiologic agent of pediatric lower respiratory infections, including bronchiolitis and pneumonia. Two antigenic subgroups, HRSV-A and B, each contain several genotypes. While viral load may vary among HRSV genotypes and affect the clinical course of disease, data are scarce regarding the actual differences among genotypes. Therefore, this study estimated and compared viral load among NA1 and ON1 genotypes of HRSV-A and BA9 of HRSV-B. ON1 is a newly emerged genotype with a 72-nucleotide duplication in the G gene as observed previously with BA genotypes in HRSV-B | ||
| 520 | |a FINDINGS: Children <5 years of age with an initial diagnosis of severe or very severe pneumonia at a hospital in the Philippines from September 2012 to December 2013 were enrolled. HRSV genotypes were determined and the viral load measured from nasopharyngeal swabs (NPS). The viral load of HRSV genotype NA1 were significantly higher than those of ON1 and BA9. Regression analysis showed that both genotype NA1 and younger age were significantly associated with high HRSV viral load | ||
| 520 | |a CONCLUSIONS: The viral load of NA1 was higher than that of ON1 and BA9 in NPS samples. HRSV genotypes may be associated with HRSV viral load. The reasons and clinical impacts of these differences in viral load among HRSV genotypes require further evaluation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Children | |
| 650 | 4 | |a Genotype | |
| 650 | 4 | |a Pneumonia | |
| 650 | 4 | |a Respiratory syncytial virus | |
| 650 | 4 | |a Viral load | |
| 700 | 1 | |a Okamoto, Michiko |e verfasserin |4 aut | |
| 700 | 1 | |a Furuse, Yuki |e verfasserin |4 aut | |
| 700 | 1 | |a Tamaki, Raita |e verfasserin |4 aut | |
| 700 | 1 | |a Suzuki, Akira |e verfasserin |4 aut | |
| 700 | 1 | |a Lirio, Irene |e verfasserin |4 aut | |
| 700 | 1 | |a Dapat, Clyde |e verfasserin |4 aut | |
| 700 | 1 | |a Malasao, Rungnapa |e verfasserin |4 aut | |
| 700 | 1 | |a Saito, Mariko |e verfasserin |4 aut | |
| 700 | 1 | |a Pedrera-Rico, Gay Anne Granada |e verfasserin |4 aut | |
| 700 | 1 | |a Tallo, Veronica |e verfasserin |4 aut | |
| 700 | 1 | |a Lupisan, Socorro |e verfasserin |4 aut | |
| 700 | 1 | |a Saito, Mayuko |e verfasserin |4 aut | |
| 700 | 1 | |a Oshitani, Hitoshi |e verfasserin |4 aut | |
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