Factors influencing immunologic response to hepatitis B vaccine in adults
Hepatitis B was still a worldwide health problem. This study aimed to conducted a systematic review and meta-analysis to assess a more precise estimation of factors that influence the response to hepatitis B vaccine in adults. Our included studies examined seroprotection rates close to the end of vaccination schedules in healthy adult populations. This meta-analysis including 21053 adults in 37 articles showed that a significantly decreased response to hepatitis B vaccine appeared in adults (age ≥ 40) (RR:1.86, 95% CI:1.55-2.23), male adults (RR:1.40, 95% CI:1.22-1.61), BMI ≥ 25 adults (RR:1.56, 95% CI:1.12-2.17), smoker (RR:1.53, 95% CI:1.21-1.93), and adults with concomitant disease (RR:1.39, 95% CI:1.04-1.86). Meanwhile, we further found a decreased response to hepatitis B vaccine appeared in adults (age ≥ 30) (RR:1.77, 95% CI:1.48-2.10), and adults (age ≥ 60) (RR:1.30, 95% CI:1.01-1.68). However, there were no difference in response to hepatitis B vaccine both in alcoholic (RR:0.90, 95% CI:0.64-1.26) and 0-1-12 vs. 0-1-6 vaccination schedule (RR:1.39, 95% CI:0.41-4.67). Pooling of these studies recommended the sooner the better for adult hepatitis B vaccine strategy. More vaccine doses, supplemental/additional strengthening immunity should be emphasized on the susceptible population of increasing aged, male, BMI ≥ 25, smoking and concomitant disease. The conventional 0-1-6 vaccination schedule could be still worth to be recommended.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:6 |
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| Enthalten in: |
Scientific reports - 6(2016) vom: 21. Juni, Seite 27251 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yang, Shigui [VerfasserIn] |
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| Links: |
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| Themen: |
Hepatitis B Vaccines |
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| Anmerkungen: |
Date Completed 10.03.2017 Date Revised 10.03.2022 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1038/srep27251 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM261596462 |
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| 245 | 1 | 0 | |a Factors influencing immunologic response to hepatitis B vaccine in adults |
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| 520 | |a Hepatitis B was still a worldwide health problem. This study aimed to conducted a systematic review and meta-analysis to assess a more precise estimation of factors that influence the response to hepatitis B vaccine in adults. Our included studies examined seroprotection rates close to the end of vaccination schedules in healthy adult populations. This meta-analysis including 21053 adults in 37 articles showed that a significantly decreased response to hepatitis B vaccine appeared in adults (age ≥ 40) (RR:1.86, 95% CI:1.55-2.23), male adults (RR:1.40, 95% CI:1.22-1.61), BMI ≥ 25 adults (RR:1.56, 95% CI:1.12-2.17), smoker (RR:1.53, 95% CI:1.21-1.93), and adults with concomitant disease (RR:1.39, 95% CI:1.04-1.86). Meanwhile, we further found a decreased response to hepatitis B vaccine appeared in adults (age ≥ 30) (RR:1.77, 95% CI:1.48-2.10), and adults (age ≥ 60) (RR:1.30, 95% CI:1.01-1.68). However, there were no difference in response to hepatitis B vaccine both in alcoholic (RR:0.90, 95% CI:0.64-1.26) and 0-1-12 vs. 0-1-6 vaccination schedule (RR:1.39, 95% CI:0.41-4.67). Pooling of these studies recommended the sooner the better for adult hepatitis B vaccine strategy. More vaccine doses, supplemental/additional strengthening immunity should be emphasized on the susceptible population of increasing aged, male, BMI ≥ 25, smoking and concomitant disease. The conventional 0-1-6 vaccination schedule could be still worth to be recommended | ||
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| 700 | 1 | |a Tian, Guo |e verfasserin |4 aut | |
| 700 | 1 | |a Cui, Yuanxia |e verfasserin |4 aut | |
| 700 | 1 | |a Ding, Cheng |e verfasserin |4 aut | |
| 700 | 1 | |a Deng, Min |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Chengbo |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Kaijin |e verfasserin |4 aut | |
| 700 | 1 | |a Ren, Jingjing |e verfasserin |4 aut | |
| 700 | 1 | |a Yao, Jun |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Yiping |e verfasserin |4 aut | |
| 700 | 1 | |a Cao, Qing |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Ping |e verfasserin |4 aut | |
| 700 | 1 | |a Xie, Tiansheng |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Chencheng |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Bing |e verfasserin |4 aut | |
| 700 | 1 | |a Mao, Chen |e verfasserin |4 aut | |
| 700 | 1 | |a Ruan, Bing |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Tian'an |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Lanjuan |e verfasserin |4 aut | |
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