Overweight is a predictor of long-term survival in hospitalised patients with exacerbations of COPD
Copyright © 2016 Elsevier Ltd. All rights reserved..
BACKGROUND: Although hospitalisations due to an exacerbation of chronic obstructive pulmonary disease (COPD) are associated with increased risk of mortality, there is little information on long-term survival after severe COPD exacerbations.
METHODS: The 5-year and 8-year overall survival after hospitalisation due to a COPD exacerbation was explored. In addition, potential predictors of survival were analysed.
RESULTS: The 57 patients with COPD included in this analysis had a median age of 70 years, a median smoking history of 30 pack years and a median forced expiratory volume in the first second (FEV1) of 41.6% predicted at the time of COPD exacerbation. The majority of the patients had either normal weight (body mass index, BMI 18.5-24.99 kg/m(2): 42%) or overweight (BMI ≥ 25 kg/m(2): 54%). The 5-year overall survival after exacerbation was 54%, the 8-year overall survival 42%. The presence of cardiac comorbidities, a FEV1 <50% predicted, an age >70 years and a BMI <25 kg/m(2), but not smoking history or current smoking, were associated with decreased overall survival. Multivariate regression analysis revealed that only BMI, age and FEV1 were independent predictors of long-term survival. Overweight patients (BMI ≥ 25 kg/m(2)) had a substantially higher 5-year overall survival (74%) than patients with a BMI < 25 kg/m(2) (31%).
CONCLUSION: Nearly half of the patients hospitalised due to an exacerbation of COPD die within 5 years after the event. Overweight is a positive predictor of long-term survival in these patients.
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:116 |
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| Enthalten in: |
Respiratory medicine - 116(2016) vom: 14. Juli, Seite 59-62 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Stoll, Paul [VerfasserIn] |
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| Links: |
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| Themen: |
COPD |
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| Anmerkungen: |
Date Completed 18.12.2017 Date Revised 21.03.2022 published: Print-Electronic CommentIn: Respir Med. 2017 Apr;125:103. - PMID 27519976 Citation Status MEDLINE |
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| doi: |
10.1016/j.rmed.2016.05.016 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM261351664 |
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| 500 | |a Date Revised 21.03.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: Respir Med. 2017 Apr;125:103. - PMID 27519976 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2016 Elsevier Ltd. All rights reserved. | ||
| 520 | |a BACKGROUND: Although hospitalisations due to an exacerbation of chronic obstructive pulmonary disease (COPD) are associated with increased risk of mortality, there is little information on long-term survival after severe COPD exacerbations | ||
| 520 | |a METHODS: The 5-year and 8-year overall survival after hospitalisation due to a COPD exacerbation was explored. In addition, potential predictors of survival were analysed | ||
| 520 | |a RESULTS: The 57 patients with COPD included in this analysis had a median age of 70 years, a median smoking history of 30 pack years and a median forced expiratory volume in the first second (FEV1) of 41.6% predicted at the time of COPD exacerbation. The majority of the patients had either normal weight (body mass index, BMI 18.5-24.99 kg/m(2): 42%) or overweight (BMI ≥ 25 kg/m(2): 54%). The 5-year overall survival after exacerbation was 54%, the 8-year overall survival 42%. The presence of cardiac comorbidities, a FEV1 <50% predicted, an age >70 years and a BMI <25 kg/m(2), but not smoking history or current smoking, were associated with decreased overall survival. Multivariate regression analysis revealed that only BMI, age and FEV1 were independent predictors of long-term survival. Overweight patients (BMI ≥ 25 kg/m(2)) had a substantially higher 5-year overall survival (74%) than patients with a BMI < 25 kg/m(2) (31%) | ||
| 520 | |a CONCLUSION: Nearly half of the patients hospitalised due to an exacerbation of COPD die within 5 years after the event. Overweight is a positive predictor of long-term survival in these patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a COPD | |
| 650 | 4 | |a Exacerbations | |
| 650 | 4 | |a Mortality | |
| 650 | 4 | |a Survival | |
| 700 | 1 | |a Foerster, Saskia |e verfasserin |4 aut | |
| 700 | 1 | |a Virchow, J Christian |e verfasserin |4 aut | |
| 700 | 1 | |a Lommatzsch, Marek |e verfasserin |4 aut | |
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