Heteromeric amino acid transporters. In search of the molecular bases of transport cycle mechanisms
© 2016 Authors; published by Portland Press Limited..
Heteromeric amino acid transporters (HATs) are relevant targets for structural studies. On the one hand, HATs are involved in inherited and acquired human pathologies. On the other hand, these molecules are the only known examples of solute transporters composed of two subunits (heavy and light) linked by a disulfide bridge. Unfortunately, structural knowledge of HATs is scarce and limited to the atomic structure of the ectodomain of a heavy subunit (human 4F2hc-ED) and distant prokaryotic homologues of the light subunits that share a LeuT-fold. Recent data on human 4F2hc/LAT2 at nanometer resolution revealed 4F2hc-ED positioned on top of the external loops of the light subunit LAT2. Improved resolution of the structure of HATs, combined with conformational studies, is essential to establish the structural bases for light subunit recognition and to evaluate the functional relevance of heavy and light subunit interactions for the amino acid transport cycle.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2016 |
|---|---|
| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:44 |
|---|---|
| Enthalten in: |
Biochemical Society transactions - 44(2016), 3 vom: 15. Juni, Seite 745-52 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Palacín, Manuel [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 28.07.2017 Date Revised 19.12.2017 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.1042/BST20150294 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM261254219 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM261254219 | ||
| 003 | DE-627 | ||
| 005 | 20231224195145.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231224s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1042/BST20150294 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0870.xml |
| 035 | |a (DE-627)NLM261254219 | ||
| 035 | |a (NLM)27284037 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Palacín, Manuel |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Heteromeric amino acid transporters. In search of the molecular bases of transport cycle mechanisms |
| 264 | 1 | |c 2016 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 28.07.2017 | ||
| 500 | |a Date Revised 19.12.2017 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2016 Authors; published by Portland Press Limited. | ||
| 520 | |a Heteromeric amino acid transporters (HATs) are relevant targets for structural studies. On the one hand, HATs are involved in inherited and acquired human pathologies. On the other hand, these molecules are the only known examples of solute transporters composed of two subunits (heavy and light) linked by a disulfide bridge. Unfortunately, structural knowledge of HATs is scarce and limited to the atomic structure of the ectodomain of a heavy subunit (human 4F2hc-ED) and distant prokaryotic homologues of the light subunits that share a LeuT-fold. Recent data on human 4F2hc/LAT2 at nanometer resolution revealed 4F2hc-ED positioned on top of the external loops of the light subunit LAT2. Improved resolution of the structure of HATs, combined with conformational studies, is essential to establish the structural bases for light subunit recognition and to evaluate the functional relevance of heavy and light subunit interactions for the amino acid transport cycle | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a amino acid transporters | |
| 650 | 4 | |a heterodimer | |
| 650 | 4 | |a heteromeric amino acid transporter (HAT) | |
| 650 | 4 | |a modelling | |
| 650 | 4 | |a structure | |
| 650 | 4 | |a transport mechanism | |
| 650 | 7 | |a Amino Acid Transport Systems |2 NLM | |
| 700 | 1 | |a Errasti-Murugarren, Ekaitz |e verfasserin |4 aut | |
| 700 | 1 | |a Rosell, Albert |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Biochemical Society transactions |d 1976 |g 44(2016), 3 vom: 15. Juni, Seite 745-52 |w (DE-627)NLM000003379 |x 1470-8752 |7 nnns |
| 773 | 1 | 8 | |g volume:44 |g year:2016 |g number:3 |g day:15 |g month:06 |g pages:745-52 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1042/BST20150294 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 44 |j 2016 |e 3 |b 15 |c 06 |h 745-52 | ||