Coeliac disease in the elderly in a tertiary centre
INTRODUCTION AND AIMS: Coeliac disease (CD) was believed to be a childhood disease while it can affect any age.
AIM: to evaluate the prevalence of CD in elderly population, recording the main clinical features of this group respect to young patients.
METHODS: We retrospectively analysed the prevalence of CD in an elderly population from 1970 to 2015. We divided patients into three age-groups (group A: 18-34 years; group B: 35-64 years; group C: ≥65 years) and compared them regarding baseline anthropometric and serological variables, clinical features at diagnosis, diagnostic mode, associated autoimmune diseases, and CD-related neoplastic complications.
RESULTS: We made 2812 CD diagnoses in adults: 2.5% of them were ≥65 years at diagnosis. When comparing the three groups, we found no differences in sex, haemoglobin, serum iron, albumin, and anti-tissue transglutaminase (anti-tTG) (p = NS) while as expected, we found higher values of cholesterol, glycaemia, and triglycerides in older patients (p < 0.0001). Elderly had a higher risk of being diagnosed with malabsorption symptoms compared to younger patients (OR 2.20, 95%CI 1.3-3.74). No difference in the risk of autoimmune CD-related diseases was seen among groups. Furthermore, we observed 16 neoplastic complications, 13 of them happened in the patients diagnosed with CD aged 35-64 years. The number of CD diagnoses increased over time, particularly in elderly.
CONCLUSION: CD diagnosis in elderly population is quite uncommon although not rare. Elderly CD patients have a higher risk of being diagnosed with malabsorption symptoms than younger patients but without increased risk of autoimmune and neoplastic complications.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2016 |
|---|---|
| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:51 |
|---|---|
| Enthalten in: |
Scandinavian journal of gastroenterology - 51(2016), 10 vom: 23. Okt., Seite 1179-83 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Tortora, Raffaella [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 06.06.2017 Date Revised 04.12.2021 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1080/00365521.2016.1186222 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM260902780 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM260902780 | ||
| 003 | DE-627 | ||
| 005 | 20231224194408.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231224s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1080/00365521.2016.1186222 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0869.xml |
| 035 | |a (DE-627)NLM260902780 | ||
| 035 | |a (NLM)27243273 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Tortora, Raffaella |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Coeliac disease in the elderly in a tertiary centre |
| 264 | 1 | |c 2016 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 06.06.2017 | ||
| 500 | |a Date Revised 04.12.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a INTRODUCTION AND AIMS: Coeliac disease (CD) was believed to be a childhood disease while it can affect any age | ||
| 520 | |a AIM: to evaluate the prevalence of CD in elderly population, recording the main clinical features of this group respect to young patients | ||
| 520 | |a METHODS: We retrospectively analysed the prevalence of CD in an elderly population from 1970 to 2015. We divided patients into three age-groups (group A: 18-34 years; group B: 35-64 years; group C: ≥65 years) and compared them regarding baseline anthropometric and serological variables, clinical features at diagnosis, diagnostic mode, associated autoimmune diseases, and CD-related neoplastic complications | ||
| 520 | |a RESULTS: We made 2812 CD diagnoses in adults: 2.5% of them were ≥65 years at diagnosis. When comparing the three groups, we found no differences in sex, haemoglobin, serum iron, albumin, and anti-tissue transglutaminase (anti-tTG) (p = NS) while as expected, we found higher values of cholesterol, glycaemia, and triglycerides in older patients (p < 0.0001). Elderly had a higher risk of being diagnosed with malabsorption symptoms compared to younger patients (OR 2.20, 95%CI 1.3-3.74). No difference in the risk of autoimmune CD-related diseases was seen among groups. Furthermore, we observed 16 neoplastic complications, 13 of them happened in the patients diagnosed with CD aged 35-64 years. The number of CD diagnoses increased over time, particularly in elderly | ||
| 520 | |a CONCLUSION: CD diagnosis in elderly population is quite uncommon although not rare. Elderly CD patients have a higher risk of being diagnosed with malabsorption symptoms than younger patients but without increased risk of autoimmune and neoplastic complications | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Coeliac disease | |
| 650 | 4 | |a diagnosis | |
| 650 | 4 | |a elderly | |
| 650 | 4 | |a epidemiology | |
| 650 | 4 | |a prevalence | |
| 650 | 7 | |a Autoantibodies |2 NLM | |
| 650 | 7 | |a Immunoglobulin A |2 NLM | |
| 650 | 7 | |a Triglycerides |2 NLM | |
| 650 | 7 | |a Cholesterol |2 NLM | |
| 650 | 7 | |a 97C5T2UQ7J |2 NLM | |
| 650 | 7 | |a Protein Glutamine gamma Glutamyltransferase 2 |2 NLM | |
| 650 | 7 | |a EC 2.3.2.13 |2 NLM | |
| 650 | 7 | |a Transglutaminases |2 NLM | |
| 650 | 7 | |a EC 2.3.2.13 |2 NLM | |
| 650 | 7 | |a GTP-Binding Proteins |2 NLM | |
| 650 | 7 | |a EC 3.6.1.- |2 NLM | |
| 700 | 1 | |a Zingone, Fabiana |e verfasserin |4 aut | |
| 700 | 1 | |a Rispo, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Bucci, Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Capone, Pietro |e verfasserin |4 aut | |
| 700 | 1 | |a Imperatore, Nicola |e verfasserin |4 aut | |
| 700 | 1 | |a Caporaso, Nicola |e verfasserin |4 aut | |
| 700 | 1 | |a D'Agosto, Domenico |e verfasserin |4 aut | |
| 700 | 1 | |a Ciacci, Carolina |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Scandinavian journal of gastroenterology |d 1966 |g 51(2016), 10 vom: 23. Okt., Seite 1179-83 |w (DE-627)NLM000055166 |x 1502-7708 |7 nnns |
| 773 | 1 | 8 | |g volume:51 |g year:2016 |g number:10 |g day:23 |g month:10 |g pages:1179-83 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1080/00365521.2016.1186222 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 51 |j 2016 |e 10 |b 23 |c 10 |h 1179-83 | ||