Poor Outcome of Stroke Patients With Atrial Fibrillation in the Presence of Coexisting Spontaneous Echo Contrast
© 2016 American Heart Association, Inc..
BACKGROUND AND PURPOSE: Spontaneous echo contrast (SEC) is frequently detected in patients with atrial fibrillation (AF). Coexisting SEC in patients with AF may be associated with heightened thrombogenicity, which affects stroke outcomes.
METHODS: Consecutive stroke patients with nonvalvular AF who underwent transesophageal echocardiography were included in this study. We compared initial stroke severity and functional outcome at 3 months between the patients with and those without SEC.
RESULTS: Of 440 patients with nonvalvular AF who underwent transesophageal echocardiography during a 7-year period, 193 (43.9%) patients had SEC. Stroke was more severe in the patients with SEC than in those without SEC (National Institute of Health Stroke Scale score: median [interquartile range], 5 [2-12] versus 3 [1-8]; P=0.004). The patients with SEC more frequently had poor functional outcomes (modified Rankin scale score of >2) at 3 months than those without SEC (32.3% versus 16.1%; P<0.001). On multivariate analysis, the presence of SEC was an independent factor of poor outcome (odds ratio, 2.09; 95% confidence interval, 1.24-3.53).
CONCLUSIONS: In the ischemic stroke patients with nonvalvular AF, coexisting SEC was associated with more severe stroke and was predictive of poor long-term functional outcome.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:47 |
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| Enthalten in: |
Stroke - 47(2016), 7 vom: 17. Juli, Seite 1920-2 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yoo, Joonsang [VerfasserIn] |
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| Links: |
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| Themen: |
Atrial fibrillation |
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| Anmerkungen: |
Date Completed 23.05.2017 Date Revised 03.03.2018 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1161/STROKEAHA.116.013351 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM260431656 |
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| 100 | 1 | |a Yoo, Joonsang |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Poor Outcome of Stroke Patients With Atrial Fibrillation in the Presence of Coexisting Spontaneous Echo Contrast |
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| 500 | |a Date Revised 03.03.2018 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2016 American Heart Association, Inc. | ||
| 520 | |a BACKGROUND AND PURPOSE: Spontaneous echo contrast (SEC) is frequently detected in patients with atrial fibrillation (AF). Coexisting SEC in patients with AF may be associated with heightened thrombogenicity, which affects stroke outcomes | ||
| 520 | |a METHODS: Consecutive stroke patients with nonvalvular AF who underwent transesophageal echocardiography were included in this study. We compared initial stroke severity and functional outcome at 3 months between the patients with and those without SEC | ||
| 520 | |a RESULTS: Of 440 patients with nonvalvular AF who underwent transesophageal echocardiography during a 7-year period, 193 (43.9%) patients had SEC. Stroke was more severe in the patients with SEC than in those without SEC (National Institute of Health Stroke Scale score: median [interquartile range], 5 [2-12] versus 3 [1-8]; P=0.004). The patients with SEC more frequently had poor functional outcomes (modified Rankin scale score of >2) at 3 months than those without SEC (32.3% versus 16.1%; P<0.001). On multivariate analysis, the presence of SEC was an independent factor of poor outcome (odds ratio, 2.09; 95% confidence interval, 1.24-3.53) | ||
| 520 | |a CONCLUSIONS: In the ischemic stroke patients with nonvalvular AF, coexisting SEC was associated with more severe stroke and was predictive of poor long-term functional outcome | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a atrial fibrillation | |
| 650 | 4 | |a cardioembolism | |
| 650 | 4 | |a ischemic stroke | |
| 650 | 4 | |a spontaneous echo contrast | |
| 700 | 1 | |a Song, Dongbeom |e verfasserin |4 aut | |
| 700 | 1 | |a Baek, Jang-Hyun |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Young Dae |e verfasserin |4 aut | |
| 700 | 1 | |a Nam, Hyo Suk |e verfasserin |4 aut | |
| 700 | 1 | |a Hong, Geu-Ru |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Jinkwon |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Hye Sun |e verfasserin |4 aut | |
| 700 | 1 | |a Heo, Ji Hoe |e verfasserin |4 aut | |
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