Aberrant regional neural fluctuations and functional connectivity in generalized anxiety disorder revealed by resting-state functional magnetic resonance imaging
Copyright © 2016 Elsevier Ireland Ltd. All rights reserved..
The purpose of this study was to investigate the neural activity and functional connectivity in generalized anxiety disorder (GAD) during resting state, and how these alterations correlate to patients' symptoms. Twenty-eight GAD patients and 28 matched healthy controls underwent resting-state functional magnetic resonance (fMRI) scans. Amplitude of low-frequency fluctuation (ALFF) and seed-based resting-state functional connectivity (RSFC) were computed to explore regional activity and functional integration, and were compared between the two groups using the voxel-based two-sample t test. Pearson's correlation analyses were performed to examine the neural relationships with demographics and clinical symptoms scores. Compared to controls, GAD patients showed functional abnormalities: higher ALFF in the bilateral dorsomedial prefrontal cortex, bilateral dorsolateral prefrontal cortex and left precuneus/posterior cingulate cortex; lower connectivity in prefrontal gyrus; lower in prefrontal-limbic and cingulate RSFC and higher prefrontal-hippocampus RSFC were correlated with clinical symptoms severity, but these associations were unable to withstand correction for multiple testing. These findings may help facilitate further understanding of the potential neural substrate of GAD.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2016 |
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Erschienen: |
2016 |
Enthalten in: |
Zur Gesamtaufnahme - volume:624 |
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Enthalten in: |
Neuroscience letters - 624(2016) vom: 15. Juni, Seite 78-84 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Wang, Wei [VerfasserIn] |
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Links: |
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Themen: |
Amplitude of low frequency fluctuations |
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Anmerkungen: |
Date Completed 06.06.2017 Date Revised 14.02.2018 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1016/j.neulet.2016.05.005 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM260199184 |
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520 | |a Copyright © 2016 Elsevier Ireland Ltd. All rights reserved. | ||
520 | |a The purpose of this study was to investigate the neural activity and functional connectivity in generalized anxiety disorder (GAD) during resting state, and how these alterations correlate to patients' symptoms. Twenty-eight GAD patients and 28 matched healthy controls underwent resting-state functional magnetic resonance (fMRI) scans. Amplitude of low-frequency fluctuation (ALFF) and seed-based resting-state functional connectivity (RSFC) were computed to explore regional activity and functional integration, and were compared between the two groups using the voxel-based two-sample t test. Pearson's correlation analyses were performed to examine the neural relationships with demographics and clinical symptoms scores. Compared to controls, GAD patients showed functional abnormalities: higher ALFF in the bilateral dorsomedial prefrontal cortex, bilateral dorsolateral prefrontal cortex and left precuneus/posterior cingulate cortex; lower connectivity in prefrontal gyrus; lower in prefrontal-limbic and cingulate RSFC and higher prefrontal-hippocampus RSFC were correlated with clinical symptoms severity, but these associations were unable to withstand correction for multiple testing. These findings may help facilitate further understanding of the potential neural substrate of GAD | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Amplitude of low frequency fluctuations | |
650 | 4 | |a Functional connectivity | |
650 | 4 | |a Generalized anxiety disorder | |
650 | 4 | |a Limbic structures | |
650 | 4 | |a Prefrontal cortex | |
700 | 1 | |a Hou, Jingming |e verfasserin |4 aut | |
700 | 1 | |a Qian, Shaowen |e verfasserin |4 aut | |
700 | 1 | |a Liu, Kai |e verfasserin |4 aut | |
700 | 1 | |a Li, Bo |e verfasserin |4 aut | |
700 | 1 | |a Li, Min |e verfasserin |4 aut | |
700 | 1 | |a Peng, Zhaohui |e verfasserin |4 aut | |
700 | 1 | |a Xin, Kuolin |e verfasserin |4 aut | |
700 | 1 | |a Sun, Gang |e verfasserin |4 aut | |
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