Satellite Cells in Muscular Dystrophy - Lost in Polarity
Copyright © 2016 Elsevier Ltd. All rights reserved..
Recent findings employing the mdx mouse model for Duchenne muscular dystrophy (DMD) have revealed that muscle satellite stem cells play a direct role in contributing to disease etiology and progression of DMD, the most common and severe form of muscular dystrophy. Lack of dystrophin expression in DMD has critical consequences in satellite cells including an inability to establish cell polarity, abrogation of asymmetric satellite stem-cell divisions, and failure to enter the myogenic program. Thus, muscle wasting in dystrophic mice is not only caused by myofiber fragility but is exacerbated by intrinsic satellite cell dysfunction leading to impaired regeneration. Despite intense research and clinical efforts, there is still no effective cure for DMD. In this review we highlight recent research advances in DMD and discuss the current state of treatment and, importantly, how we can incorporate satellite cell-targeted therapeutic strategies to correct satellite cell dysfunction in DMD.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2016 |
|---|---|
| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
|---|---|
| Enthalten in: |
Trends in molecular medicine - 22(2016), 6 vom: 10. Juni, Seite 479-496 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Chang, Natasha C [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 30.06.2017 Date Revised 11.01.2019 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.molmed.2016.04.002 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM26018361X |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM26018361X | ||
| 003 | DE-627 | ||
| 005 | 20231224192838.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231224s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.molmed.2016.04.002 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0867.xml |
| 035 | |a (DE-627)NLM26018361X | ||
| 035 | |a (NLM)27161598 | ||
| 035 | |a (PII)S1471-4914(16)30006-5 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Chang, Natasha C |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Satellite Cells in Muscular Dystrophy - Lost in Polarity |
| 264 | 1 | |c 2016 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 30.06.2017 | ||
| 500 | |a Date Revised 11.01.2019 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2016 Elsevier Ltd. All rights reserved. | ||
| 520 | |a Recent findings employing the mdx mouse model for Duchenne muscular dystrophy (DMD) have revealed that muscle satellite stem cells play a direct role in contributing to disease etiology and progression of DMD, the most common and severe form of muscular dystrophy. Lack of dystrophin expression in DMD has critical consequences in satellite cells including an inability to establish cell polarity, abrogation of asymmetric satellite stem-cell divisions, and failure to enter the myogenic program. Thus, muscle wasting in dystrophic mice is not only caused by myofiber fragility but is exacerbated by intrinsic satellite cell dysfunction leading to impaired regeneration. Despite intense research and clinical efforts, there is still no effective cure for DMD. In this review we highlight recent research advances in DMD and discuss the current state of treatment and, importantly, how we can incorporate satellite cell-targeted therapeutic strategies to correct satellite cell dysfunction in DMD | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Duchenne muscular dystrophy | |
| 650 | 4 | |a Mark2 | |
| 650 | 4 | |a Par1b | |
| 650 | 4 | |a Pard3 | |
| 650 | 4 | |a asymmetric division | |
| 650 | 4 | |a dystrophin | |
| 650 | 4 | |a regenerative myogenesis | |
| 650 | 4 | |a satellite cells | |
| 650 | 4 | |a stem cell polarity | |
| 650 | 7 | |a Dystrophin |2 NLM | |
| 700 | 1 | |a Chevalier, Fabien P |e verfasserin |4 aut | |
| 700 | 1 | |a Rudnicki, Michael A |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Trends in molecular medicine |d 2001 |g 22(2016), 6 vom: 10. Juni, Seite 479-496 |w (DE-627)NLM111960800 |x 1471-499X |7 nnns |
| 773 | 1 | 8 | |g volume:22 |g year:2016 |g number:6 |g day:10 |g month:06 |g pages:479-496 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.molmed.2016.04.002 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 22 |j 2016 |e 6 |b 10 |c 06 |h 479-496 | ||