Clinicopathological study of purpura : Is a skin biopsy necessary for palpable purpura?
Copyright © 2016 Elsevier Masson SAS. All rights reserved..
OBJECTIVE: For many physicians, palpable purpura is synonymous with vasculitis. However, a skin biopsy is almost always performed in common clinical practice in order to confirm the diagnosis. The aim of our study was to assess whether palpable purpura is always indicative of an inflammatory infiltrate in a vessel wall.
PATIENTS AND METHODS: Eighty-seven patients were included in this prospective monocentric study, 45 of whom were presenting a palpable purpura. Patients were classified in two categories: "leukocytoclastic vasculitis" or "other diagnosis". The clinical and histopathological features of patients with a palpable purpura were studied.
RESULTS: The mean age of patients presenting a palpable purpura was 69 years. There were 26 men and 19 women. Of the 43 patients biopsied, 37 were included in the vasculitis group. The sensitivity, specificity, positive predictive value and negative predictive value for a diagnosis of vasculitis in patients with palpable purpura were respectively 82, 65, 86 and 58 %. The Odds ratio was 8.48 (95 % CI, 2.52-31.80; P<0.05).
CONCLUSION: Most of the palpable purpuras examined were indeed related to leukocytoclastic vasculitis. In the remaining cases, biopsy did not contribute to the diagnosis since it only showed purpura without vessel wall inflammation. In our opinion, a skin biopsy is thus not essential where the clinical presentation is typical.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:143 |
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| Enthalten in: |
Annales de dermatologie et de venereologie - 143(2016), 5 vom: 01. Mai, Seite 347-53 |
| Sprache: |
Französisch |
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| Weiterer Titel: |
Étude anatomo-clinique du purpura : y a-t-il un intérêt à biopsier un purpura palpable ? |
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| Beteiligte Personen: |
Jung, A-J [VerfasserIn] |
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| Links: |
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| Themen: |
Biopsie cutanée |
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| Anmerkungen: |
Date Completed 14.06.2017 Date Revised 03.12.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.annder.2016.02.024 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM259454869 |
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| 245 | 1 | 0 | |a Clinicopathological study of purpura |b Is a skin biopsy necessary for palpable purpura? |
| 246 | 3 | 3 | |a Étude anatomo-clinique du purpura : y a-t-il un intérêt à biopsier un purpura palpable ? |
| 264 | 1 | |c 2016 | |
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| 500 | |a Date Revised 03.12.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2016 Elsevier Masson SAS. All rights reserved. | ||
| 520 | |a OBJECTIVE: For many physicians, palpable purpura is synonymous with vasculitis. However, a skin biopsy is almost always performed in common clinical practice in order to confirm the diagnosis. The aim of our study was to assess whether palpable purpura is always indicative of an inflammatory infiltrate in a vessel wall | ||
| 520 | |a PATIENTS AND METHODS: Eighty-seven patients were included in this prospective monocentric study, 45 of whom were presenting a palpable purpura. Patients were classified in two categories: "leukocytoclastic vasculitis" or "other diagnosis". The clinical and histopathological features of patients with a palpable purpura were studied | ||
| 520 | |a RESULTS: The mean age of patients presenting a palpable purpura was 69 years. There were 26 men and 19 women. Of the 43 patients biopsied, 37 were included in the vasculitis group. The sensitivity, specificity, positive predictive value and negative predictive value for a diagnosis of vasculitis in patients with palpable purpura were respectively 82, 65, 86 and 58 %. The Odds ratio was 8.48 (95 % CI, 2.52-31.80; P<0.05) | ||
| 520 | |a CONCLUSION: Most of the palpable purpuras examined were indeed related to leukocytoclastic vasculitis. In the remaining cases, biopsy did not contribute to the diagnosis since it only showed purpura without vessel wall inflammation. In our opinion, a skin biopsy is thus not essential where the clinical presentation is typical | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Biopsie cutanée | |
| 650 | 4 | |a Leukocytoclastic vasculitis | |
| 650 | 4 | |a Palpable purpura | |
| 650 | 4 | |a Purpura palpable | |
| 650 | 4 | |a Skin biopsy | |
| 650 | 4 | |a Vasculite leucocytoclasique | |
| 700 | 1 | |a Schaeffer, M |e verfasserin |4 aut | |
| 700 | 1 | |a Mitcov, M |e verfasserin |4 aut | |
| 700 | 1 | |a Scrivener, Y |e verfasserin |4 aut | |
| 700 | 1 | |a Cribier, B |e verfasserin |4 aut | |
| 700 | 1 | |a Lipsker, D |e verfasserin |4 aut | |
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