Total Synthesis of Cryptocaryol A by Enantioselective Iridium-Catalyzed Alcohol C-H Allylation
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim..
The polyketide natural product cryptocaryol A is prepared in 8 steps via iridium catalyzed enantioselective diol double C-H allylation, which directly generates an acetate-based triketide stereodiad. In 4 previously reported total syntheses, 17-28 steps were required.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:55 |
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| Enthalten in: |
Angewandte Chemie (International ed. in English) - 55(2016), 16 vom: 11. Apr., Seite 5049-52 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Perez, Felix [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 13.12.2016 Date Revised 25.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/anie.201600591 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. | ||
| 520 | |a The polyketide natural product cryptocaryol A is prepared in 8 steps via iridium catalyzed enantioselective diol double C-H allylation, which directly generates an acetate-based triketide stereodiad. In 4 previously reported total syntheses, 17-28 steps were required | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a enantioselective synthesis | |
| 650 | 4 | |a iridium | |
| 650 | 4 | |a polyketide | |
| 650 | 4 | |a total synthesis | |
| 650 | 4 | |a transfer hydrogenation | |
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| 700 | 1 | |a Waldeck, Andrew R |e verfasserin |4 aut | |
| 700 | 1 | |a Krische, Michael J |e verfasserin |4 aut | |
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