Treatment-resistant psychosis due to interaction between ritonavir and olanzapine : case report and literature review
Patients with schizophrenia are eight times more likely than healthy individuals to become infected with the human immunodeficiency virus (hiv). Although in vitro studies provide some data on the interaction between antipsychotics and retroviral agents, there is a lack of in vitro data on this subject. We describe the case of a 35-year-old patient who suffered from schizophrenia, polydrug abuse and an hiv infection and who also had treatment-resistant psychosis. An interaction between the antiretroviral drug ritonavir and the antipsychotic olanzapine turned out to be the cause of the treatment resistance. As far as we know, this is the first report of such a clinically relevant interaction. We present a review of the current literature on this type of interaction.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:58 |
|---|---|
| Enthalten in: |
Tijdschrift voor psychiatrie - 58(2016), 4 vom: 13., Seite 309-13 |
| Sprache: |
Niederländisch |
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| Weiterer Titel: |
Therapieresistente psychose door interactie tussen ritonavir en olanzapine |
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| Beteiligte Personen: |
van Oeffelt, Th [VerfasserIn] |
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| Themen: |
12794-10-4 |
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| Anmerkungen: |
Date Completed 11.10.2016 Date Revised 02.12.2018 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM259373540 |
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| 245 | 1 | 0 | |a Treatment-resistant psychosis due to interaction between ritonavir and olanzapine |b case report and literature review |
| 246 | 3 | 3 | |a Therapieresistente psychose door interactie tussen ritonavir en olanzapine |
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| 500 | |a Date Completed 11.10.2016 | ||
| 500 | |a Date Revised 02.12.2018 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Patients with schizophrenia are eight times more likely than healthy individuals to become infected with the human immunodeficiency virus (hiv). Although in vitro studies provide some data on the interaction between antipsychotics and retroviral agents, there is a lack of in vitro data on this subject. We describe the case of a 35-year-old patient who suffered from schizophrenia, polydrug abuse and an hiv infection and who also had treatment-resistant psychosis. An interaction between the antiretroviral drug ritonavir and the antipsychotic olanzapine turned out to be the cause of the treatment resistance. As far as we know, this is the first report of such a clinically relevant interaction. We present a review of the current literature on this type of interaction | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a Journal Article | |
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