The rapid progress of heart failure due to systemic amyloidosis with cardiac involvement--case report
UNLABELLED: Amyloidosis is a disease having many different faces. Different symptoms may appear, depending on which organ is involved. That's why correct diagnosis can be difficult. Cardiac involvement must always be considered because of poor prognosis (30 to 68 % patients survive one year). Also in case of rapid progress of cardiac wall thickening, amyloidosis should be taken into account.
MATERIAL AND METHODS: we present a case of a female patient with rapid progress of heart failure due to systemic amyloidosis with cardiac involvement.
CASE REPORT: 48-old female, with no prior medical history, admitted to cardiology ward because of dyspnea on exertion and leg edema. Couple days before admission hypertrophic cardiomyopathy was diagnosed. Laboratory test revealed elevated troponin I, d-dimers and BNP (natriuretic peptide type B). Electrocardiogram showed low QRS voltage in limb leads. Echocardiography confirmed concentric thickening of left ventricular walls and reduced ejection fraction (40%). We performed cardiac magnetic resonance. Morphology of the delayed enhancement and an increased signal in T2 dependent sequences suggested overlap of general inflammatory process and hypertrophic cardiomyopathy. Because of amyloidosis suspicion, gingival and subcutaneous adipose tissue biopsies were performed. Sirius red stain identified amyloid only in the walls of gingival blood vessels. Diagnosis of amyloidosis was established and further diagnostics planned. Soon after patients condition worsened. Finally, in intensive care unit, after cardiac arrest patient died.
CONCLUSION: Amyloidosis with cardiac involvement has a very poor prognosis. Multiple tissue biopsy and histopathological assessment should lead to correct diagnosis and proper treatment.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:72 |
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| Enthalten in: |
Przeglad lekarski - 72(2015), 11 vom: 01., Seite 697-700 |
| Sprache: |
Polnisch |
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| Weiterer Titel: |
Gwałtownie postepujaca niewydolność krazenia w przebiegu amyloidozy z zajeciem serca-opis przypadku |
|---|
| Beteiligte Personen: |
Gilowski, Wojciech [VerfasserIn] |
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| Themen: |
114471-18-0 |
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| Anmerkungen: |
Date Completed 25.05.2016 Date Revised 25.03.2016 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM258760117 |
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| 100 | 1 | |a Gilowski, Wojciech |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The rapid progress of heart failure due to systemic amyloidosis with cardiac involvement--case report |
| 246 | 3 | 3 | |a Gwałtownie postepujaca niewydolność krazenia w przebiegu amyloidozy z zajeciem serca-opis przypadku |
| 264 | 1 | |c 2015 | |
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| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 25.05.2016 | ||
| 500 | |a Date Revised 25.03.2016 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a UNLABELLED: Amyloidosis is a disease having many different faces. Different symptoms may appear, depending on which organ is involved. That's why correct diagnosis can be difficult. Cardiac involvement must always be considered because of poor prognosis (30 to 68 % patients survive one year). Also in case of rapid progress of cardiac wall thickening, amyloidosis should be taken into account | ||
| 520 | |a MATERIAL AND METHODS: we present a case of a female patient with rapid progress of heart failure due to systemic amyloidosis with cardiac involvement | ||
| 520 | |a CASE REPORT: 48-old female, with no prior medical history, admitted to cardiology ward because of dyspnea on exertion and leg edema. Couple days before admission hypertrophic cardiomyopathy was diagnosed. Laboratory test revealed elevated troponin I, d-dimers and BNP (natriuretic peptide type B). Electrocardiogram showed low QRS voltage in limb leads. Echocardiography confirmed concentric thickening of left ventricular walls and reduced ejection fraction (40%). We performed cardiac magnetic resonance. Morphology of the delayed enhancement and an increased signal in T2 dependent sequences suggested overlap of general inflammatory process and hypertrophic cardiomyopathy. Because of amyloidosis suspicion, gingival and subcutaneous adipose tissue biopsies were performed. Sirius red stain identified amyloid only in the walls of gingival blood vessels. Diagnosis of amyloidosis was established and further diagnostics planned. Soon after patients condition worsened. Finally, in intensive care unit, after cardiac arrest patient died | ||
| 520 | |a CONCLUSION: Amyloidosis with cardiac involvement has a very poor prognosis. Multiple tissue biopsy and histopathological assessment should lead to correct diagnosis and proper treatment | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Troponin I |2 NLM | |
| 650 | 7 | |a Natriuretic Peptide, Brain |2 NLM | |
| 650 | 7 | |a 114471-18-0 |2 NLM | |
| 700 | 1 | |a Stryjewski, Piotr |e verfasserin |4 aut | |
| 700 | 1 | |a Gilowska, Małgorzata |e verfasserin |4 aut | |
| 700 | 1 | |a Liszniański, Piotr |e verfasserin |4 aut | |
| 700 | 1 | |a Nowak, Jacek |e verfasserin |4 aut | |
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