STABILITY OF CEFPIROME SULFATE IN AQUEOUS SOLUTIONS
The influence of pH on the stability of cefpirome sulfate was investigated in the pH range of 0.44 - 13.00. The degradation of cefpirome sulfate as a result of hydrolysis was a pseudo-first-order reaction. General acid-base hydrolysis of cefpirome sulfate was not observed. In the solutions of hydrochloric acid, sodium hydroxide, acetate, borate and phosphate buffer, k(obs) = k(pH) because specific acid-base catalysis was observed. Specific acid-base catalysis of cefpirome sulfate consisted of the following reactions: hydrolysis of cefpirome sulfate catalyzed by hydrogen ions (kH+), hydrolysis of dications (k₁H₂O) monocations (k₂ H₂O), zwitter ions (k₃H₂O) and monoanions (k₄ H₂O) of cefpirome sulfate under the influence of water. The total rate of the reaction was equal to the sum of partial reactions k(pH) = kH+ x aH+ + kH₂O x f₁ + k₂H₂O x f₂ + k₃H₂O x f₃ + k₄ H₂O x f₄. Based on the dependence k(pH) = f(pH) it was found that cefpirome sulfate was the most stable in aqueous solutions in the pH range of 4-6.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:73 |
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| Enthalten in: |
Acta poloniae pharmaceutica - 73(2016), 1 vom: 23. Jan., Seite 23-7 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zalewski, Przemysław [VerfasserIn] |
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| Themen: |
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| Anmerkungen: |
Date Completed 28.04.2016 Date Revised 13.12.2023 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM258728078 |
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| 500 | |a published: Print | ||
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| 520 | |a The influence of pH on the stability of cefpirome sulfate was investigated in the pH range of 0.44 - 13.00. The degradation of cefpirome sulfate as a result of hydrolysis was a pseudo-first-order reaction. General acid-base hydrolysis of cefpirome sulfate was not observed. In the solutions of hydrochloric acid, sodium hydroxide, acetate, borate and phosphate buffer, k(obs) = k(pH) because specific acid-base catalysis was observed. Specific acid-base catalysis of cefpirome sulfate consisted of the following reactions: hydrolysis of cefpirome sulfate catalyzed by hydrogen ions (kH+), hydrolysis of dications (k₁H₂O) monocations (k₂ H₂O), zwitter ions (k₃H₂O) and monoanions (k₄ H₂O) of cefpirome sulfate under the influence of water. The total rate of the reaction was equal to the sum of partial reactions k(pH) = kH+ x aH+ + kH₂O x f₁ + k₂H₂O x f₂ + k₃H₂O x f₃ + k₄ H₂O x f₄. Based on the dependence k(pH) = f(pH) it was found that cefpirome sulfate was the most stable in aqueous solutions in the pH range of 4-6 | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 7 | |a Cephalosporins |2 NLM | |
| 650 | 7 | |a Solutions |2 NLM | |
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| 700 | 1 | |a Paczkowska, Magdalena |e verfasserin |4 aut | |
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| 700 | 1 | |a Talaczyńska, Alicja |e verfasserin |4 aut | |
| 700 | 1 | |a Stfpniak, Piotr |e verfasserin |4 aut | |
| 700 | 1 | |a Cielecka-Piontek, Judyta |e verfasserin |4 aut | |
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