Hypertension Is Associated With Undiagnosed OSA During Rapid Eye Movement Sleep
Copyright © 2016 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved..
BACKGROUND: Evidence linking OSA with hypertension in population studies is conflicting. We examined longitudinal and cross-sectional associations of previously unrecognized OSA, including OSA occurring in rapid eye movement (REM) sleep, with hypertension.
METHODS: The Men Androgens Inflammation Lifestyle Environment and Stress (MAILES) study is a longitudinal study of community-dwelling men in Adelaide, South Australia. Biomedical assessments at baseline (2002-2006) and follow-up (2007-2010) identified hypertension (systolic ≥ 140 mm Hg and/or diastolic ≥ 90 mm Hg, or medication) and risk factors. In 2010 to 2011, 837 men without a prior diagnosis of OSA underwent full in-home unattended polysomnography of whom 739 recorded ≥ 30 min of REM sleep. Hypertension at follow-up (concomitant with OSA status) was defined as prevalent hypertension. Recent-onset hypertension was defined as hypertension at biomedical follow-up (56 months mean follow-up [range, 48-74]) in men free of hypertension at baseline.
RESULTS: Severe REM OSA (apnea hypopnea index ≥30/h) showed independent adjusted associations with prevalent (OR, 2.40, 95% CI, 1.42-4.06), and recent-onset hypertension (2.24 [1.04-4.81]). Significant associations with non-REM AHI were not seen. In men with AHI < 10, REM OSA (apnea hypopnea index) ≥ 20/h was significantly associated with prevalent hypertension (2.67 [1.33-5.38]) and the relationship with recent-onset hypertension was positive but not statistically significant (2.32 [0.79-6.84]). Similar results were seen when analyses were confined to men with non-REM AHI < 10.
CONCLUSIONS: In men not considered to have OSA (AHI < 10), hypertension was associated with OSA during REM sleep. REM OSA may need consideration as an important clinical entity requiring treatment but further systematic assessment and evidence is needed.
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:150 |
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| Enthalten in: |
Chest - 150(2016), 3 vom: 28. Sept., Seite 495-505 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Appleton, Sarah L [VerfasserIn] |
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| Links: |
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| Themen: |
Epidemiology |
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| Anmerkungen: |
Date Completed 24.05.2017 Date Revised 30.03.2022 published: Print-Electronic CommentIn: Chest. 2016 Sep;150(3):475-7. - PMID 27613971 Citation Status MEDLINE |
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| doi: |
10.1016/j.chest.2016.03.010 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM258655917 |
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| 100 | 1 | |a Appleton, Sarah L |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Hypertension Is Associated With Undiagnosed OSA During Rapid Eye Movement Sleep |
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| 500 | |a Date Revised 30.03.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: Chest. 2016 Sep;150(3):475-7. - PMID 27613971 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2016 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a BACKGROUND: Evidence linking OSA with hypertension in population studies is conflicting. We examined longitudinal and cross-sectional associations of previously unrecognized OSA, including OSA occurring in rapid eye movement (REM) sleep, with hypertension | ||
| 520 | |a METHODS: The Men Androgens Inflammation Lifestyle Environment and Stress (MAILES) study is a longitudinal study of community-dwelling men in Adelaide, South Australia. Biomedical assessments at baseline (2002-2006) and follow-up (2007-2010) identified hypertension (systolic ≥ 140 mm Hg and/or diastolic ≥ 90 mm Hg, or medication) and risk factors. In 2010 to 2011, 837 men without a prior diagnosis of OSA underwent full in-home unattended polysomnography of whom 739 recorded ≥ 30 min of REM sleep. Hypertension at follow-up (concomitant with OSA status) was defined as prevalent hypertension. Recent-onset hypertension was defined as hypertension at biomedical follow-up (56 months mean follow-up [range, 48-74]) in men free of hypertension at baseline | ||
| 520 | |a RESULTS: Severe REM OSA (apnea hypopnea index ≥30/h) showed independent adjusted associations with prevalent (OR, 2.40, 95% CI, 1.42-4.06), and recent-onset hypertension (2.24 [1.04-4.81]). Significant associations with non-REM AHI were not seen. In men with AHI < 10, REM OSA (apnea hypopnea index) ≥ 20/h was significantly associated with prevalent hypertension (2.67 [1.33-5.38]) and the relationship with recent-onset hypertension was positive but not statistically significant (2.32 [0.79-6.84]). Similar results were seen when analyses were confined to men with non-REM AHI < 10 | ||
| 520 | |a CONCLUSIONS: In men not considered to have OSA (AHI < 10), hypertension was associated with OSA during REM sleep. REM OSA may need consideration as an important clinical entity requiring treatment but further systematic assessment and evidence is needed | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a epidemiology | |
| 650 | 4 | |a hypertension | |
| 650 | 4 | |a men | |
| 650 | 4 | |a obstructive sleep apnea | |
| 650 | 4 | |a rapid eye movement sleep | |
| 700 | 1 | |a Vakulin, Andrew |e verfasserin |4 aut | |
| 700 | 1 | |a Martin, Sean A |e verfasserin |4 aut | |
| 700 | 1 | |a Lang, Carol J |e verfasserin |4 aut | |
| 700 | 1 | |a Wittert, Gary A |e verfasserin |4 aut | |
| 700 | 1 | |a Taylor, Anne W |e verfasserin |4 aut | |
| 700 | 1 | |a McEvoy, R Doug |e verfasserin |4 aut | |
| 700 | 1 | |a Antic, Nick A |e verfasserin |4 aut | |
| 700 | 1 | |a Catcheside, Peter G |e verfasserin |4 aut | |
| 700 | 1 | |a Adams, Robert J |e verfasserin |4 aut | |
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